A5071227728- Nuclear physics research studies
- Atomic and Molecular Physics
- Nuclear Physics and Applications
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Physics Studies
- Laser-induced spectroscopy and plasma
- Astronomical and nuclear sciences
- Laser-Plasma Interactions and Diagnostics
- Laser Design and Applications
- Coronary Interventions and Diagnostics
- Particle accelerators and beam dynamics
- Atomic and Subatomic Physics Research
- Quantum Chromodynamics and Particle Interactions
- Receptor Mechanisms and Signaling
- Spectroscopy and Laser Applications
- Particle physics theoretical and experimental studies
- Acute Myocardial Infarction Research
- Nuclear reactor physics and engineering
- Cold Atom Physics and Bose-Einstein Condensates
- Radioactive element chemistry and processing
- Astro and Planetary Science
- Cardiac Imaging and Diagnostics
- Physical Activity and Health
- Pericarditis and Cardiac Tamponade
- Advanced Frequency and Time Standards
University of Manchester
2016-2025
Justus-Liebig-Universität Gießen
2025
University of Michigan
2021-2023
Michigan United
2023
Carolinas Healthcare System
2015-2017
Montana Department of Public Health and Human Services
2015-2017
Spectrum Health
2016
Bon Secours Heart & Vascular Institute
2014-2015
American Cancer Society
2010-2015
Carolinas Medical Center
2015
The obesity epidemic is attributed in part to reduced physical activity. Evidence supports that reducing time spent sitting, regardless of activity, may improve the metabolic consequences obesity. Analyses were conducted a large prospective study US adults enrolled by American Cancer Society examine leisure sitting and activity relation mortality. Time queried questionnaire on 53,440 men 69,776 women who disease free at enrollment. authors identified 11,307 deaths 7,923 during 14-year...
Abstract We have studied cyclic AMP-mediated regulation of the beta 2-adrenergic receptor (beta 2AR). The effects cAMP were assessed in Chinese hamster fibroblast (CHW) cells expressing either wild type human 2AR (CH-beta 2) or mutated forms lacking consensus sequences for phosphorylation by cAMP-dependent protein kinase. Treatment CH-beta 2 with analogue dibutyryl (Bt2cAMP) induces a time-dependent down-regulation number 2AR. This receptors is accompanied decline steady state level mRNA....
Three separate processes may contribute to rapid beta-adrenergic receptor desensitization: functional uncoupling from the stimulatory guanine nucleotide-binding protein Gs, mediated by phosphorylation of receptors two distinct kinases, specific kinase (beta ARK) and cyclic AMP-dependent A (PKA), as well a spatial via sequestration away cell surface. To evaluate relative importance potential role various in different physiological situations, kinetic analysis these three mechanisms was...
Plasma membrane receptors that couple to guanine nucleotide-binding regulatory proteins (G proteins) undergo a variety of rapid (minutes) and longer term (hours) processes induced by ligands. For the beta 2-adrenergic receptor (beta 2AR), include functional desensitization, mediated phosphorylation cAMP-dependent protein kinase beta-adrenergic kinase, as well loss hydrophilic ligand binding proposed represent sequestration into cellular compartment distinct from plasma membrane. The slower...
A new method has been developed for increasing the sensitivity of collinear laser spectroscopy. The utilizes an ion-trapping technique in which a continuous low-energy ion beam is cooled and accumulated linear Paul trap subsequently released as short (10-20 micros) bunch. In measurements signal-to-noise ratio improved by factor 2 x 10(4), allowing spectroscopic to be made with ion-beam fluxes approximately 50 ions s(-1). bunching demonstrated on-line isotope shift hyperfine structure...
The first on-line laser spectroscopy of cooled fission fragments is reported. $^{\mathrm{96}\mathrm{--}\mathrm{102}}\mathrm{Z}\mathrm{r}$ ions, produced in uranium fission, were extracted and separated using an ion guide isotope separator. ions bunched for collinear by a gas-filled linear Paul trap. New results nuclear mean-square charge radii, dipole, quadrupole moments are reported across the $N=60$ shape change. radii found to be almost identical those Sr isotones previously offered...
The integrity of coupling the beta 2-adrenergic receptor (beta 2AR) to its guanine nucleotide-binding protein, Gs, and phosphorylation events on molecule have been proposed be important determinants in processes sequestration down-regulation. However, little is known about molecular mechanisms underlying these processes, regions that specifically subserve down-regulation yet delineated. To address questions, we stably transfected eight mutant 2AR genes into Chinese hamster fibroblasts...
A gas-filled segmented linear Paul trap has been installed at the focal plane of high-resolution separator (HRS) CERN-ISOLDE. As well as providing beams with a reduced transverse emittance, this device is also able to accumulate ions and release sample in bunches well-defined time structure. This recently permitted collinear laser spectroscopy stable radioactive bunched be demonstrated ISOLDE. Surface-ionized 39, 44, 46K 85Rb were accelerated 30keV, mass separated injected into for...
A new method of optical pumping in an ion beam cooler buncher has been developed to selectively enhance ionic metastable state populations. The technique permits the study elements previously inaccessible laser spectroscopy and applied here Nb. Model independent mean-square charge radii nuclear moments have studied for ;{90,90 m,91,91 m,92,93,99,101,103}Nb cover region N=50 shell closure N approximately 60 sudden onset deformation. increase radius is observed be less than that Y, with a...
Modern techniques of laser spectroscopy enable measurements optical isotope shifts and hyperfine structures to be extended across long chains isotopes reaching far from the region stability. While structure yields precise information on spin electromagnetic moments nucleus, are sensitive small differential changes in size shape nuclear charge distribution. The experimental situation is reviewed, with an emphasis used for rare radioactive species. status data summarized. Modified King plots...
Radioisotopes of molybdenum have been studied using laser spectroscopy techniques at the IGISOL facility, University Jyväskylä. Differences in nuclear charge radii determined for neutron deficient isotopes 90,91Mo and rich 102–106,108Mo (and all stable isotopes). A smooth transition mean square is observed as number increases with no sudden shape change region around N=60. As N increases, deformation appears to go beyond a maximum fall off N=66 observed. The magnetic moments odd 91,103,105Mo...
Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence mortality worldwide, but they are uncommon in Western countries. Little information exists on association between vitamin D risk upper GI cancers. This study examined circulating 25-hydroxyvitamin (25(OH)D) cancer Cohort Consortium Vitamin Pooling Project Rarer Cancers. Concentrations 25(OH)D were measured from 1,065 cases 1,066 age-, sex-, race-, season-of blood draw–matched controls 8 prospective cohort...
<h3>Objective</h3> Non-steroidal anti-inflammatory drug (NSAID) use decreases both the incidence of colorectal cancer and recurrence adenomas among patients with prior neoplasia. However, few studies have investigated association between NSAID cancer-specific survival. The role prediagnostic was therefore examined in relation to survival cases from Seattle Colon Cancer Family Registry (Seattle CFR). <h3>Methods</h3> This a follow-up study that included incident CFR. Cases were aged 20–74,...
Background: For men and women, taller height is associated with increased risk of all cancers combined. colorectal cancer (CRC), it unclear whether the differential association by sex real or due to confounding bias inherent in observational studies. We performed a Mendelian randomization study examine between CRC risk. Methods: To minimize bias, we derived weighted genetic score predicting (using 696 variants height) 10 226 cases 286 controls. Logistic regression was used estimate odds...
Few studies have assessed the relation between dietary patterns and gastric adenocarcinoma risk, yet this approach has advantages over single-nutrient analysis, including ability to reflect eating in populations ease of implementing recommendations. The authors evaluated associations patterns, a food index score, incident cancer risk Canadian study 1,169 cases 2,332 controls (1995–1997). Dietary were via factor analysis applied frequency questionnaire. A score was derived based on factors...
The first optical study of the N=28 shell closure in manganese is reported. Mean-square charge radii and quadrupole moments, obtained for ground isomeric states 50–56Mn, are extracted using new calculations atomic factors. show a well defined at magic number. behaviour strikingly different to that neutron separation energies where no effect can be observed. nuclear parameters successfully described by large scale model GXPF1A interaction.
Collinear laser spectroscopy experiments with the Sc + transition 3d4s 3 D 2 → 3d4p F at λ = 363.1 nm were performed on 42-46 isotopic chain using an ion guide isotope separator a cooler-buncher.Nuclear magnetic dipole and electric quadrupole moments as well shifts determined from hyperfine structure for five ground states two isomers.Extensive multiconfigurational Dirac-Fock calculations in order to evaluate specific mass-shift, M SMS , field-shift, F, parameters which allowed evaluation of...
Abstract Understanding the evolution of nuclear charge radius is one long-standing challenges for theory. Recently, density functional theory calculations utilizing Fayans functionals have successfully reproduced radii a variety exotic isotopes. However, difficulties in isotope production hindered testing these models immediate region chart below heaviest self-conjugate doubly-magic nucleus 100 Sn, where near-equal number protons ( Z ) and neutrons N lead to enhanced neutron-proton pairing....
The impact of nuclear deformation can been seen in the systematics charge radii, with radii generally expanding increasing deformation. In this Letter, we present a detailed analysis precise relationship between quadrupole and size. Our approach combines first measurements changes mean-square well-deformed palladium isotopes A=98 A=118 density functional calculations using Fayans functionals, specifically Fy(std) Fy(Δr,HFB), UNEDF2 functional. are extracted from collinear laser spectroscopy...
FURIOS, the Fast Universal laser IOn Source, is under development at IGISOL (Ion Guide Isotope Separator On-Line) mass separator facility in Jyvaskyla, Finland. This new ion source will combine a state-of-the-art solid state system together with dye system, for selective and efficient production of exotic radioactive species without compromising universality fast release inherent system. The motivation for, of, this discussed relation to programme research ongoing facility.