A5024495651- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Palliative Care and End-of-Life Issues
- Colorectal Cancer Screening and Detection
- Viral-associated cancers and disorders
- Economic and Financial Impacts of Cancer
- Neuroscience and Neuropharmacology Research
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Mercury impact and mitigation studies
- Ion channel regulation and function
- Oral health in cancer treatment
- Global Cancer Incidence and Screening
- Radiopharmaceutical Chemistry and Applications
- Cancer Risks and Factors
- Circular RNAs in diseases
- Environmental Justice and Health Disparities
- Trace Elements in Health
- Cervical Cancer and HPV Research
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Bacterial Identification and Susceptibility Testing
- Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Head and Neck Cancer Studies
Fred Hutch Cancer Center
2015-2025
VA Puget Sound Health Care System
2018-2025
Health Services Research & Development
2023-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2014-2023
Cancer Research Center
2016-2022
United States Department of Veterans Affairs
2019
University of Washington
2011-2018
Kidney Research UK
2017
University of Wisconsin Carbone Cancer Center
2016
University of Wisconsin–Madison
2016
In people living with HIV (PLWH) on antiretroviral therapy (ART), virus persists in a latent form where there is minimal transcription or protein expression. Latently infected cells are major barrier to curing HIV. Increasing and viral production latently could facilitate immune recognition reduce the pool of that persist ART. Given programmed cell death 1 (PD-1) expressing CD4 + T preferentially PLWH ART, we aimed determine whether administration antibodies targeting PD-1 would reverse...
To explore the potential for use of ligand-conjugated nanocrystals to target cell surface receptors, ion channels, and transporters, we explored ability serotonin-labeled CdSe (SNACs) interact with antidepressant-sensitive, human Drosophila serotonin transporters (hSERT, dSERT) expressed in HeLa HEK-293 cells. Unlike unconjugated nanocrystals, SNACs were found dose-dependently inhibit transport radiolabeled by hSERT dSERT, an estimated half-maximal activity (EC50) 33 (dSERT) 99 μM (hSERT)....
This study examined prospective data from the Third National Health and Nutrition Examination Survey (NHANES III) cohort to investigate relationship between cadmium exposure cancer mortality, specific cancers associated with exposure, in general population.Vital status cause of death through 31 December 2006 were obtained by Center for Statistics NHANES III participants. The concentration spot urine samples was measured corrected creatinine (uCd). Weighted Cox proportional hazards regression...
Using a case-control design, we evaluated differences in risk factors for colorectal polyps according to histological type, anatomical site, and severity. Participants were enrollees the Group Health Cooperative aged 20–79 years who underwent colonoscopy Seattle, Washington, between 1998 2007 comprised 628 adenoma cases, 594 serrated polyp 247 cases with both types of polyps, 1,037 polyp-free controls. completed structured interview, via standardized pathology review. We used multivariable...
Purpose To compare incidence and survival of peripheral T-cell lymphoma (PTCL) subtypes among US racial/ethnic groups. Methods Patients with PTCL (age ≥ 15 years; 2000 to 2012) were identified in the Surveillance, Epidemiology, End Results (SEER) registries. Race/ethnicity was categorized as non-Hispanic white, black, Asian/Pacific Islander, Hispanic or American Indian/Alaskan native. Age-standardized annual rates rate ratios estimated 95% CIs, case-case odds by race/ethnicity using...
In vitro and animal data suggest that cadmium, a heavy metal contaminates some foods tobacco plants, is an estrogenic endocrine disruptor. Elevated estrogen exposure associated with breast, endometrial, ovarian cancer risk.We examined the association between dietary cadmium intake risk of these cancers in large, well-characterized Women's Health Initiative (WHI).A total 155,069 postmenopausal women, 50-79 years age, who were enrolled WHI clinical trials or observational study, participated...
Background and objectives Although a peritoneal equilibration test yields data on three parameters (4-hour dialysate/plasma creatinine, 4- to 0-hour dialysate glucose, 4-hour ultrafiltration volume), all studies have focused the prognostic value of creatinine for patients undergoing dialysis. Because glucose volume may be superior in predicting daily ultrafiltration, likely mechanism association results with outcomes, we hypothesized that they are risk prediction. Design, setting,...
Abstract Purpose Interactive clinical video telemedicine (CVT) has the potential to benefit health care systems and patients by improving access, lowering costs, more efficiently distributing providers. However, there is a gap in current knowledge around demand for uses of CVT large integrated systems. Methods We conducted an observational study using Veterans Health Administration (VHA) administrative databases analyze trends utilization, types received, among 7.65 million veterans during...
Purpose Regular use of aspirin is associated with improved survival for patients colorectal cancer (CRC). However, the timing and subtype CRC that would benefit most from using other nonsteroidal anti-inflammatory drugs (NSAIDs) in relation to unclear. Patients Methods In all, 2,419 age 18 74 years incident invasive who were diagnosed 1997 2008 identified population-based registries United States, Canada, Australia. Detailed epidemiologic questionnaires administered at study enrollment...
The authors have created US mortality rates (age, sex, race, and calendar-time specific) proportions, using multiple cause-of-death data, for the years 1960–1989. Multiple data include usual underlying cause of death from certificate as well contributory causes other significant conditions. multiple-cause proportions enable user to calculate expected occurrences disease on certificates a cohort under study. There is an average 2.66 and/or conditions listed certificates, increasing over time...
<h3>Objective</h3> Non-steroidal anti-inflammatory drug (NSAID) use decreases both the incidence of colorectal cancer and recurrence adenomas among patients with prior neoplasia. However, few studies have investigated association between NSAID cancer-specific survival. The role prediagnostic was therefore examined in relation to survival cases from Seattle Colon Cancer Family Registry (Seattle CFR). <h3>Methods</h3> This a follow-up study that included incident CFR. Cases were aged 20–74,...
Hospitalization is a major source of morbidity among patients with ESRD undergoing maintenance hemodialysis and significant contributor to health care costs. To identify subgroups at the highest risk hospitalization, we analyzed by sex, age, race, adjusting for demographic clinical characteristics, hospitalization rates, 30-day readmissions 333,756 hospitalizations 111,653 in facilities operated large dialysis organization United States (2007–2011). The overall rate was 1.85 per person-year...
Background and Aim Because most colorectal cancer patients survive beyond five years, understanding quality of life among these long-term survivors is essential to providing comprehensive survivor care. We sought identify personal characteristics associated with reported in survivors, sub-groups potentially vulnerable very low life. Methods assessed using the Veterans RAND 12-item Health Survey within a population-based sample 1,021 Seattle Colorectal Cancer Family Registry, approximately 5...
Chronic lung diseases (CLDs) have been variably associated with a risk for more severe manifestations and death coronavirus disease (COVID-19).
Plasma microRNAs (miRNAs) are promising non-invasive biomarkers for colorectal cancer (CRC) prognosis. However, the published studies to date have yielded conflicting and inconsistent results specific plasma miRNAs. We conducted a study using robust assays assess panel of nine miRNAs CRC prognosis early detection recurrence. samples from 144 patients in prospective cohort were collected at diagnosis, 6, 12, 24 months after diagnosis. assayed by Taqman qRT–PCR generate miRNA normalised copy...
ABSTRACT A previously described monoclonal antibody (MAb)-based competitive-inhibition enzyme-linked immunosorbent assay (cELISA) was modified to optimize performance, and the validated in various defined cattle populations for detection of serum Neospora caninum , a major cause bovine abortion. Modifications cELISA included capturing native N. antigen with parasite-specific MAb (MAb 5B6-25) directly conjugating competitor 4A4-2), both MAbs binding different epitopes conserved,...
The inadequacies of prostate specific antigen testing have created a need for novel markers cancer screening. investigational ProCaM™ methylation assay detects aberrant DNA in cells associated with cancer. We describe large, prospective, multicenter study done to verify the performance this assay.The is designed detect epigenetic modifications 3 GSTP1, RARβ2 and APC, which are indicative A total 232 men 283 without from 18 clinical sites were evaluated by trained operators at central...
Cadmium is a widespread heavy metal pollutant that may act as an exogenous estrogenic hormone. Environmental cadmium exposure has been associated with risk of breast cancer in retrospective studies. We prospectively assessed the relationship between exposure, evaluated by creatinine-normalized urinary concentration, and invasive among 12,701 postmenopausal women aged ≥50 years Women's Health Initiative study bone mineral density. After median 13.2 follow-up (1993-2010), 508 cases 1,050...
Abstract Purpose “Endemic” Burkitt lymphoma (BL) is a common childhood cancer in Africa. Social and treatment factors may contribute to poor survival. With the aim of improving BL outcomes Uganda, we undertook comprehensive project (BL Project) that provided diagnostic support, access standard chemotherapy, nutritional evaluations, case management. We evaluated survival children with context project. Patients methods followed by Project who consented research were enrolled this study....