Andrea N. Burnett‐Hartman
A5080908362- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Palliative Care and End-of-Life Issues
- Cancer, Lipids, and Metabolism
- Economic and Financial Impacts of Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Surgical Treatments
- Cancer survivorship and care
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Nutritional Studies and Diet
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Ethics in Clinical Research
- Frailty in Older Adults
- Head and Neck Cancer Studies
- Cannabis and Cannabinoid Research
- Oral health in cancer treatment
Kaiser Permanente
2016-2025
National Cancer Institute
2024-2025
Fred Hutch Cancer Center
2014-2024
University of Washington
2008-2024
The University of Melbourne
2012-2024
Albert Einstein College of Medicine
2024
Norwegian University of Science and Technology
2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2010-2024
Cancer Research Center
2012-2024
Baylor College of Medicine
2024
Abstract The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this in relation to COVID-19 severity. In our analysis of patients European ( n = 2,249) African 835) ancestries hospitalized versus nonhospitalized COVID-19, the risk was a common OAS1 haplotype, which also reduced severe acute respiratory syndrome 2 (SARS-CoV-2) clearance trial...
Background: Lung cancer screening (LCS) using low-dose computed tomography (LDCT) reduces lung mortality but can lead to downstream procedures, complications, and other potential harms. Estimates of these events outside NLST (National Screening Trial) have been variable lacked evaluation by result, which allows more direct comparison with trials. Objective: To identify rates procedures complications associated LCS. Design: Retrospective cohort study. Setting: 5 U.S. health care systems....
Abstract Background:BRAF mutations in colorectal cancer (CRC) are disproportionately observed tumors exhibiting microsatellite instability (MSI) and associated with other prognostic factors. The independent association between BRAF mutation status CRC survival, however, remains unclear. Methods: We evaluated the c.1799T>A (p.V600E) survival individuals incident invasive diagnosed 1997 2007 Western Washington State. Tumor specimens were tested for this MSI status. used Cox regression...
Abstract Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or sex is unclear. Further, metabolic alterations mediating effects on CRC are not fully understood. Methods We examined sex- and site-specific associations with adiposity-associated metabolites explain CRC. Genetic variants from genome-wide association studies body mass index (BMI) waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), 123...
Background & AimsHuman studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and binding protein 3 (IGFBP3) colorectal cancer risk have reported inconsistent results. We conducted complementary serologic Mendelian randomization (MR) analyses to determine whether alterations in IGF1 or IGFBP3 are associated with development.MethodsSerum were measured blood samples collected from 397,380 participants the UK Biobank, 2006 through 2010. Incident cases...
Abstract Background: To reduce colorectal cancer mortality, positive fecal blood tests must be followed by colonoscopy. Methods: We identified 62,384 individuals ages 50 to 89 years with a test between January 1, 2011 and December 31, 2012 in four health care systems within the Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium. estimated probability of follow-up colonoscopy 95% confidence intervals (CI) using Kaplan–Meier method. Overall...
Rationale: Black patients receive recommended lung cancer screening (LCS) follow-up care less frequently than White patients, but it is unknown if this racial disparity persists across both decentralized and centralized LCS programs. Objectives: To determine adherence to American College of Radiology Lung Imaging Reporting Data System (Lung-RADS) recommendations among individuals undergoing at either or programs evaluate the association race with adherence. Methods: We performed a...
Uptake of new systemic therapy treatments among patients with advanced non-small cell lung cancer (NSCLC) occurred rapidly after FDA approval. Few studies have characterized the association these therapies on survival in community settings. We assessed by type received diagnosed NSCLC who were treated community-based In this retrospective cohort, de novo stage IV between March 2012 and December 2020 followed through 31, 2021. Survival was ascertained restricted mean time from treatment...
A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status these markers in polyps evaluated associated risk factors. The study included 771 polyp cases 1,027 controls who were ages 24 to 80 years, part group health program, received colonoscopy from 1998 2007, completed structured questionnaire assessing Following standard pathology review,...
Purpose Regular use of aspirin is associated with improved survival for patients colorectal cancer (CRC). However, the timing and subtype CRC that would benefit most from using other nonsteroidal anti-inflammatory drugs (NSAIDs) in relation to unclear. Patients Methods In all, 2,419 age 18 74 years incident invasive who were diagnosed 1997 2008 identified population-based registries United States, Canada, Australia. Detailed epidemiologic questionnaires administered at study enrollment...
<h3>Importance</h3> The US Preventive Services Task Force (USPSTF) released updated lung cancer screening recommendations in 2021, lowering the age from 55 to 50 years and smoking history 30 20 pack-years. These changes are expected expand access women racial ethnic minority groups. <h3>Objective</h3> To estimate population-level associated with 2021 USPSTF expansion of eligibility by sex, race ethnicity, sociodemographic factors, comorbidities 5 community-based health care systems....