A5100334806- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- RNA modifications and cancer
- Advanced Neural Network Applications
- Bioinformatics and Genomic Networks
- Neurological Complications and Syndromes
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Human Pose and Action Recognition
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cleft Lip and Palate Research
- Gene expression and cancer classification
- Acute Kidney Injury Research
- Domain Adaptation and Few-Shot Learning
- Genomic variations and chromosomal abnormalities
Zhejiang University
2018-2023
Zhejiang Center for Disease Control and Prevention
2021
First Affiliated Hospital Zhejiang University
2018-2021
Auburn University
2019
Shanghai Institutes for Biological Sciences
2018
Chinese Academy of Sciences
2018
Abstract Most genetic variants for colorectal cancer (CRC) identified in genome-wide association studies (GWAS) are located intergenic regions, implying pathogenic dysregulations of gene expression. However, comprehensive assessments target genes CRC remain to be explored. We conducted a multi-omics analysis using transcriptome and/or DNA methylation data from the Genotype-Tissue Expression, The Cancer Genome Atlas and Colonomics projects. 116 putative 45 GWAS-identified variants. Using...
Low-Rank Adaptation (LoRA) is a crucial method for efficiently fine-tuning pretrained large language models (LLMs), with its performance largely influenced by two key factors: rank and initialization strategy. Numerous LoRA variants have been proposed to enhance addressing these factors. However, often compromise LoRA's usability or efficiency. In this paper, we analyze the fundamental limitations of existing methods introduce novel approach, GoRA (Gradient-driven Adaptive Low Rank...
Demethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses leukocyte recruitment endothelial tubular cell processes. However, of AKI is poorly defined. Our study determined degree renal tissue damage associated with gene expression levels cisplatin-induced mice model. Tet2-knockout (KO) cisplatin treatment experienced severe necrosis dilatation, inflammation, markers' than wild-type mice. In...
Transcriptomic diversity across human populations reflects differential regulatory mechanisms. Allelic-imbalanced gene expression is a genetic mechanism that contributes to phenotypic variation. To systematically investigate genome-wide allele-specific (ASE), we analyzed RNA-Seq data from European and African provided by the Geuvadis project. We identified 11 sites in 8 genes showing ASE both Europeans Africans, 9 population-specific ASE, including novel known signals. Notably, top signal of...
Abstract Transcriptome-wide association studies (TWAS) have identified many putative susceptibility genes for colorectal cancer (CRC) risk. However, miRNAs, critical dysregulators of gene expression, remain unexplored. We genotyped DNA samples from 313 CRC East Asian patients and performed small RNA sequencing in their normal colon tissues distant tumors to build genetic models predicting miRNA expression. applied these data genome-wide (GWAS) including 23 942 cases 217 267 controls ancestry...
Unaccounted population stratification can lead to false-positive findings and mask the true association signals in identification of disease-related genetic variants. The computational simplicity principal component analysis (PCA) makes it a widely used method for adjustment. However, given that genotype data are generally represented by numerical values 0, 1, 2, corresponding number minor alleles, is more reasonable consider as categorical data. Because PCA inherently only suitable...