A5100332729- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Geoscience and Mining Technology
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Breast Lesions and Carcinomas
- Rock Mechanics and Modeling
- Geomechanics and Mining Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac pacing and defibrillation studies
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
Third Affiliated Hospital of Harbin Medical University
2024-2025
Dalian Medical University
2013-2025
First Affiliated Hospital of Dalian Medical University
2012-2025
Harbin Medical University
2019-2025
Henan University
2021-2025
Jilin University
2025
Weifang People's Hospital
2020-2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Shandong Provincial QianFoShan Hospital
2022-2024
Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among leading causes cancer death whole world. The urgent needs are to find sensitive markers for early diagnosis or monitor postoperative recurrence give adequate treatment HCC. MicroRNAs (miRNAs) reported a group small non-coding RNAs that can function endogenous RNA interference regulate expression targeted genes. This study was conducted detect application miR-143 miR-215 in HCC.A total 340 serum...
Objectives Previous studies have confirmed a link between specific inflammatory cytokines and bowel disease (IBD), but the causal relationship them is not completely clear. This Mendelian Randomization (MR) study aims to evaluate 18 disease. Method Two-sample randomization utilized genetic variances associated with IBD from two extensive publicly available genome-wide association (GWAS) (Crohn’s Disease (CD): 12,194 cases 28,072 controls; Ulcerative Colitis (UC): 12,336 33,609 controls). The...
The detrimental effects of oxidative stress on the skeletal system have been documented, and understanding mechanisms is important to design a therapeutic strategy. As an antioxidant anti-inflammatory agent, active ingredient turmeric curcumin has used as medication for numerous complications including bone loss. However, it unclear if could influence osteogenic potential mesenchymal stem cells (MSCs), particularly in injuries. Here we demonstrate that treatment protects cell death caused by...
Rib spalling is a major issue affecting the safety of steeply inclined coal seam. And failure face and support system can be affected with each other to generate vicious cycle along inducing large-scale collapse surrounding rock in In order analyze mechanism propose corresponding prominent control measures working face, mechanical model based on face-support-roof was established reveal disaster rib sensitive analysis related factors performed. Furthermore, taking 3402 Chen-man-zhuang mine as...
The transforming growth factor beta (TGF-β) signaling pathway is a tumor-suppressor that commonly inactivated in colorectal cancer (CRC). inactivation of TGFBR2 the most common genetic event affecting TGF-β pathway. However, mechanism by which cells downregulate unclear. In this study, we found protein levels were consistently upregulated CRC tissues, whereas its mRNA varied these suggesting post-transcriptional involved regulation TGFBR2. Because microRNAs (miRNAs) are powerful regulators...
Long non-coding RNAs (lncRNAs) were found to regulate many biological processes including cancer development, immunology and other diseases. LncRNA HULC was be oncogenes in progression. However, the role of regulation breast remains unclear.The expression miR-6754-5p examined by RT-PCR. Through knockdown HULC, we that proliferation abilities coupled with migration invasion significantly decreased. And also, verified overexpression decreased ability cells.In this study, lncRNA overexpressed...
Breast cancer (BC) is the most common malignancy among women. Emerging studies have demonstrated that circular RNA (circRNA) zinc finger binding protein (circZFR) serves as a crucial regulator in many human cancers. However, role and mechanism of circZFR BC tumorigenesis remain unclear.The levels circZFR, miR-578 hypoxia-inducible factor 1α (HIF1A) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Cell viability, colony formation, apoptosis,...
Abstract Background Circular RNAs (circRNAs) have caught increasing attentions and interests for their important involvement in cancer initiation progression. This study aims to investigate the biological functions of circNOL10 its potential molecular mechanisms breast (BC). Materials methods qRT-PCR western blot assays were performed measure expression related genes. CCK-8, colony formation, flow cytomerty transwell used assess cell proliferation, cycle, migration invasion. RNA pull-down,...
To investigate the role of contrast-enhanced magnetic resonance imaging (CE-MRI) radiomics for pretherapeutic prediction response to transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).One hundred and twenty-two HCC (objective response, n = 63; non-response, 59) who received CE-MRI examination before initial TACE were retrospectively recruited randomly divided into a training cohort (n 85) validation 37). All HCCs manually segmented on arterial, venous...
Immune and inflammatory responses after stroke are important pathophysiological processes. This study explored the relationship between systemic immune-inflammation index (SII) prognosis. Patients from China National Stroke Registry III were investigated. SII was defined as neutrophils à platelets/lymphocytes, patients divided into four groups according to quartiles based on values. The primary outcome poor functional outcome, assessed by modified Rankin Scale (mRS), an mRS score of â¥3....
Purpose: To investigate the changes in pulmonary function after computed tomography (CT)-guided microwave ablation (MWA) patients with a malignant lung tumor. Materials and Methods: From June 2020 to January 2022, 133 tumor who underwent CT-guided percutaneous MWA were included study. Pulmonary tests (PFTs) performed before (the baseline) 1 month MWA. Vital capacity (VC), forced vital (FVC), expiratory volume second (FEV1), FEV1%, maximum mid-expiratory flow (MMEF), diffusion of for carbon...
Invasive micropapillary carcinoma (IMPC) of the breast is known for its high propensity lymph node (LN) invasion. Inadequate LN dissection may compromise precision prognostic assessments. This study introduces a log odds positive nodes (LODDS) method to address this issue and develops novel LODDS-based nomogram provide accurate information.
Deep brines in the Qaidam Basin were explored as replacement resources due to continuous and intensive exploitation of shallow high-quality solid potash salts brines. Here, chemical composition Sr, Li, H, O isotopes Mahai Salt Lake its surrounding waters, including deep confined brine, brine water solution mining block, surface runoff, fault-related water, analyzed. The composition, Li isotopes, H from alluvial fan region, Yuqia River, Dezong Lake, block generally characterized by increasing...
Sevoflurane, an inhalational general anesthetic, has become one of the most widely used anesthetics in surgery. However, previous studies have found that sevoflurane anesthesia can trigger inflammatory response, resulting secondary damage. Dexmedetomidine (DEX), a highly-selective α adrenergic receptor agonist, is as anesthetic adjuvant clinic. In this study we investigated whether DEX was able to suppress sevoflurane-induced neuroinflammation.The aim determine mechanism action suppressive...
Aim: We aimed to estimate the disease burden and risk factors attributable ovarian cancer, epidemiological trends at global, regional, national levels. Methods: described cancer data on incidence, mortality, disability-adjusted life-years as well age-standardized rates from 1990 2017 Global Health Data Exchange database. also estimated deaths life-years. Measures were stratified by region, country, age, socio-demographic index. The annual percentage changes calculated evaluate temporal...
Lung adenocarcinoma (LUAD) is the main subtype of primary lung cancer and a leading cause cancer-related death worldwide. PIWI-interacting RNAs (piRNAs) are type small non-coding that may play crucial roles in progression serve as biomarkers for tumor detection. This study aimed to explore expression profiles diagnostic values piRNAs LUAD.Small RNA sequencing was performed investigate tissue piRNA LUAD. The selected upregulated were detected tissues serum exosome samples by quantitative...
Many large and super-large copper deposits have been discovered explored in the Tibet Plateau, which makes it most important resource reserve development base China. Based on work of research team, paper summarizes geological characteristics main puts forward a further prospecting direction. A series accumulated metal or ore districts from subduction Tethys oceanic crust to India-Asia collisionhave discovered, such as Duolong Cu (Au) district Jiama polymetallic deposit. The are located...
Abstract Background Cyclin‐dependent kinase (CDK) 4/6 inhibitor plus endocrine therapy (ET) become standard‐of‐care for patients with hormone receptor‐positive, human epidermal growth factor receptor‐2 negative (HR+/HER2−) metastatic breast cancer (MBC). However, the optimal therapeutic paradigm after progression on CDK4/6 remains unclear. This study aimed to evaluate efficacy and safety of abemaciclib switching ET versus chemotherapy prior palbociclib‐based in Chinese HR+/HER2− MBC. Methods...