A5108050385- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Mitochondrial Function and Pathology
- Advanced Photocatalysis Techniques
- Catalytic Processes in Materials Science
- Animal Genetics and Reproduction
- Molecular Biology Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- MXene and MAX Phase Materials
- Neurological Complications and Syndromes
- Chronic Kidney Disease and Diabetes
- Sleep and related disorders
- COVID-19 and Mental Health
Yangzhou University
2024-2025
Lawrence Berkeley National Laboratory
2025
Hunan Agricultural University
2024
Soochow University
2017-2024
Shanghai Institute of Hematology
2018-2024
Renji Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Tianjin Medical University Cancer Institute and Hospital
2014-2024
South China Normal University
2024
National Clinical Research
2024
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage metabolism regulation by secretion adipokines. Circular RNAs (circRNAs), a novel type noncoding RNA, have recently been recognized as key factors tumor development, but role exosome circRNAs derived from adipose tissues not defined yet. Here, adipose-secreted were found regulate deubiquitination HCC, thus facilitating cell...
Alzheimer’s disease (AD) is the most common type of dementia, and promptly diagnosis AD crucial for delaying development improving patient quality life. However, detection, particularly in early stages, remains a substantial challenge due to lack specific biomarkers. The present study was undertaken identify validate potential circulating miRNAs as novel biomarkers AD. Solexa sequencing employed screen expression profile serum controls. RT-qPCR used confirm altered at individual level....
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy is retracting this article. After investigating concerns image duplication raised by a reader, evidence for in identical or altered fashion Figures 4A, 4G, and S1C was identified. reuse (and part, misrepresentation) data without appropriate attribution represents severe abuse scientific publishing system....
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with dysbiosis the gut microbiome, yet role microbiome protective effect statins CRC is unclear. Here we validated by retrospectively analysing cohort patients who underwent colonoscopies. This was confirmed patient cohorts, found that tumour burden partly due to...
ERBB3, one of the four members ErbB family receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In present study, we aimed to identify novel miRNAs that can potentially target ERBB3 their biological functions. The expression levels miR-143/145 mRNA were examined by relative quantification RT-PCR, protein detected Western blot. We used bioinformatic analyses search for ERBB3. Luciferase reporter plasmids constructed confirm direct targeting....
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy is retracting this article. After investigating concerns image duplication raised by a reader, evidence for in identical or altered fashion Figure 7B was identified. reuse (and part, misrepresentation) data without appropriate attribution represents severe abuse scientific publishing system. The authors do...
Background: Nanobodies, named as VHHs (variable domain of heavy chain HCAb [heavy-chain antibodies]), are derived from heavy-chain-only antibodies that circulate in sera camelids. Their exceptional physicochemical properties, possibility humanization, and unique antigen recognition properties make them excellent candidates for targeted delivery biologically active components, including immunotoxins. In our previous efforts, we have successfully generated the monovalent bivalent CD7...
The transforming growth factor beta (TGF-β) signaling pathway is a tumor-suppressor that commonly inactivated in colorectal cancer (CRC). inactivation of TGFBR2 the most common genetic event affecting TGF-β pathway. However, mechanism by which cells downregulate unclear. In this study, we found protein levels were consistently upregulated CRC tissues, whereas its mRNA varied these suggesting post-transcriptional involved regulation TGFBR2. Because microRNAs (miRNAs) are powerful regulators...
Abstract Background The mental health of university students during the COVID-19 pandemic has attracted attention researchers. For present study researchers constructed a mediation model to explore relationship between psychological resilience and post-traumatic growth, mediating role negative emotions moderating deliberate rumination in students. Methods Psychological Resilience Scale, Posttraumatic Growth Inventory, Depression-Anxiety-Stress Scale (DASS-21) Event Related Rumination...
The aim of this study was to investigate the role small nucleolar RNA host gene 8 (SNHG8) in pathogenesis pancreatic adenocarcinoma and explore possible underlying mechanism.SNHG8 expression 40 pairs tissues para-cancerous tissues, as well 10 normal pancreas detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Survival analysis conducted correlation between SNHG8 prognosis patients. After transfection siRNA into cells, proliferation cell cycle were counting kit-8 (CCK-8)...
We have recently shown that histone deacetylase 6 (HDAC6) is critically involved in the pathogenesis of acute kidney injury. Its role renal fibrosis, however, remains unclear. In this study, we examined effect ricolinostat (ACY-1215), a selective inhibitor HDAC6, on development fibrosis murine model induced by unilateral ureteral obstruction (UUO). HDAC6 was highly expressed following UUO injury, which coincident with deposition collagen fibrils and expression α-smooth muscle actin,...
Switchable selectivity achieved by altering reaction conditions within the same photocatalytic system offers great advantages for sustainable chemical transformations and renewable energy conversion. In this study, we investigate an efficient methanol dehydrogenation with controlled varying concentration of nickel cocatalyst, using zinc indium sulfide nanocrystals as a semiconductor photocatalyst, which enables production either formaldehyde or ethylene glycol high selectivity. Control...
Lung cancer is the leading cause of cancer-related deaths worldwide, with a poor prognosis despite advancements in diagnosis and treatment. Metabolic reprogramming, key feature cancer, allows tumor cells to survive grow under harsh conditions, making it crucial area study. This study provides comprehensive analysis global trends, influential studies, developments this field. We conducted bibliometric using Web Science Core Collection (WoSCC) database from 2004 2024. Publications related...
Objective Up to now, non-invasive diagnosis of laterally spreading tumor (LST) and prediction adenoma recurrence after endoscopic resection LSTs is inevitable. This study aimed identify a microbial signature with clinical significance diagnosing predicting colectomy. Methods We performed 16S rRNA sequencing in 24 mucosal samples, including 5 healthy controls (HC), 8 colorectal (CRA) patients, 11 LST patients. The differentiating microbiota fecal samples was quantified by qPCR 475 cases 113...
Abstract The mitochondrial DNA m.3243A > G mutation is well-known to cause a variety of clinical phenotypes, including diabetes, deafness, and osteoporosis. Here, we report isolation expansion urine-derived stem cells (USCs) from patients carrying the mutation, which demonstrate bimodal heteroplasmy. USCs with high levels displayed abnormal morphology function, as well elevated ATF5-dependent unfolded protein response (UPR mt ), together reduced Wnt/β-catenin signaling osteogenic...
Total sleep deprivation (TSD) negatively affects cognitive function. Previous research has focused on individual variation in function following TSD, but we know less about how TSD influences the lateralization of spatial working memory. This study used event-related-potential techniques to explore asymmetry spatial-working-memory impairment. Fourteen healthy male participants performed a two-back task with electroencephalogram (EEG) recordings conducted at baseline and after 36 h TSD. We...
Abstract Extracellular vesicles (EVs) are intermediaries in intercellular signal transmission and material exchange have attracted significant attention from researchers bone cartilage repair. These nanoscale hold immense potential facilitating repair regeneration by regulating the microenvironment at an injury site. However, their vivo utilization is limited self‐clearance random distribution. Therefore, various delivery platforms been developed to improve EV targeting retention rates...
Expression and function of histone deacetylases (HDACs) vary with cell types pathological conditions. Our recent studies showed that pharmacological targeting class IIa HDACs attenuated renal fibrosis, but the effect HDAC inhibition on acute kidney injury (AKI) remains unknown. In this study, we found four (4, 5, 7, 9) were highly expressed in folic acid (FA) ischemia/reperfusion (I/R)-induced AKI mice. Administration TMP269, a potent selective inhibitor, improved reduced tubular apoptosis,...
Background: Breast cancer (BC) is a major leading cause of woman deaths worldwide. Increasing evidence has revealed that stemness features are related to the prognosis and progression tumors. Nevertheless, roles stemness-index-related long noncoding RNAs (lncRNAs) in BC remain unclear. Methods: Differentially expressed lncRNAs between normal samples The Cancer Genome Atlas database were screened based on weighted gene co-expression network analysis differential analysis. Univariate Cox least...
Abstract Polycomb repressive complex 2 (PRC2) is a multicomponent with methyltransferase activity that catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). Interaction the epigenetic reader protein EED EZH2, catalytic unit PRC, allosterically stimulates PRC2 activity. In this study, we investigated role and underlying mechanism in acute kidney injury (AKI) by using EED226, highly selective inhibitor, to target EED. Administration EED226 improved renal function, attenuated...