A5100358128- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Neutrino Physics Research
- Astrophysics and Cosmic Phenomena
- Black Holes and Theoretical Physics
- Distributed and Parallel Computing Systems
- Radiation Detection and Scintillator Technologies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Muon and positron interactions and applications
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Advanced Data Storage Technologies
- advanced mathematical theories
- Atomic and Subatomic Physics Research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
University of Science and Technology of China
2016-2025
Tianjin Medical University General Hospital
2017-2025
Nanjing Tech University
2024-2025
China Medical University
2025
Purdue University West Lafayette
2021-2025
Craft Group (China)
2025
Tianjin University of Traditional Chinese Medicine
2025
Northern Illinois University
2020-2024
Institute of High Energy Physics
2017-2024
Institute for High Energy Physics
2023-2024
Using detailed simulations of calorimeter showers as training data, we investigate the use deep learning algorithms for simulation and reconstruction particles produced in high-energy physics collisions. We train neural networks on shower data at calorimeter-cell level, show significant improvements when using these compared to methods which rely currently-used state-of-the-art algorithms. define two models: an end-to-end network performs simultaneous particle identification energy...
ERBB3, one of the four members ErbB family receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In present study, we aimed to identify novel miRNAs that can potentially target ERBB3 their biological functions. The expression levels miR-143/145 mRNA were examined by relative quantification RT-PCR, protein detected Western blot. We used bioinformatic analyses search for ERBB3. Luciferase reporter plasmids constructed confirm direct targeting....
The major environmental determinants of honeybee caste development come from larval nutrients: royal jelly stimulates the differentiation larvae into queens, whereas beebread leads to worker bee fate. However, these are not fully characterized. Here we report that plant RNAs, particularly miRNAs, which more enriched in than jelly, delay and decrease body ovary size honeybees, thereby preventing queens inducing bees. Mechanistic studies reveal amTOR, a stimulatory gene differentiation, is...
Abstract Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression, but the absorption mechanism remains unknown. Here, we show that SIDT1 expressed on gastric pit cells in stomach is required for of dietary microRNAs. SIDT1-deficient mice reduced basal levels impaired dynamic Notably, identified as primary site microRNA absorption, which dramatically attenuated stomachs mice. Mechanistic analyses revealed uptake exogenous low-pH dependent. Furthermore,...
Lysosomal viscosity is a significant parameter of lysosomes and closely related to various diseases. Herein, two fluorescent probes, Lyso-vis-A Lyso-vis-B, were developed, which demonstrate diverse advantages, including great water solubility, lysosome targeting ability sensitivity. In particular, exclusively showed fluorescence response toward but was not influenced by pH changes, rendering it selective lysosomal probe. Furthermore, successfully applied monitor variations in living cells...
Abstract Background Turnover problems among primary health care workers are a significant contributor to the shortage of human resources. This study aims determine relationship between job stress and turnover intention workers, as well examine mediating effects satisfaction presenteeism on this relationship. Methods Stratified random sampling quota were used select 703 in Jilin Province, China January 2020. Validated scales measure intention, stress, satisfaction, workers. The utilized...
Survivin (encoded by the gene BIRC5) plays an important role in carcinogenesis of bladder cancer. Identifying miRNAs that target setting cancer will help to develop Survivin-based therapies for cancer.The expression levels miR-138-5p and protein were measured 12 resected specimens. The correlation between was further examined evaluating human cell lines either overexpressed or knocked down miR-138-5p. A luciferase reporter assay performed test direct binding BIRC5. We also investigated...
Dysregulation of the cell cycle is a key indicator tumors, including lung cancer. Recently, study inhibitors has made great progress in relation to However, question what kinds patients can use plagued us. Therefore, seeking an accurate and convenient marker for abnormal cancer very important. In present research, we showed that lnc RNA HOTAIR optimal dysregulation study, investigated ‐specific expression primary tumor samples by analyzing TCGA public database 67 pairs patients’ tissues...
Worldwide, non-small cell lung cancer (NSCLC) has the highest morbidity and mortality of all malignancies. The lack responsiveness to checkpoint inhibitors is a central problem in modern era immunotherapy, with rapid development immune (ICIs) recent years. human switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex been reported be recurrently mutated patients cancer, those SWI/SNF mutations have sensitive ICIs. Six cohorts, total 3416 patients, were used analyze mutation...
Metastasis is the leading cause of cancer mortality and a major hurdle for lung treatment. Invadopodia, which are cancer-specific protrusive structures, play crucial role in metastatic cascade through degradation basement membrane surrounding stroma. Cortactin, critical component invadopodia, frequently used as an invadopodia marker, universally important player function, overexpressed cancer, but exact mechanism regulation not yet fully understood. The expression level CTTN human non-small...
Abstract Long non‐coding RNA MIR503 host gene (MIR503HG) is located on chromosome Xq26.3, and has been found to be deregulated in many types of human malignancy function as tumour suppressor or promoter based cancer types. The role MIR503HG breast was still unknown. In our study, we expression significantly decreased triple‐negative tissues cell lines. Furthermore, observed low correlated with late clinical stage, lymph node metastasis distant metastasis. the survival analysis, that patients...
Anthocyanins have been known for their health benefits. However, the in vivo digestion and absorption of anthocyanins through gastrointestinal tract not fully clarified, creating challenges understanding why high biological activities purported low bioavailability vivo. Twenty-seven male rats were intubated with a 500 mg/kg dose cyanidin-3-glucoside (C3G). Samples from rats' stomach, duodenum, jejunum, ileum, colon, serum collected at 0.5, 1, 2, 3, 4, 5, 6, 12, 24 h after intubation. Three...
// Kai Yin 1, 2, 3, * , Minghui Liu Mei Zhang 4, Feng Wang Min Fen 1 Zhijian 5 Yutao Yuan Shanting Gao Liuqing Yang Weijie Jianguo 6 Baoliang Guo Jianwei Xu 3 Hongwei Liang 2 Xi Chen Wenxian Guan Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital Clinical College Medical University, Nanjing, Jiangsu 210008, China State Key Laboratory Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), Engineering Research Center MicroRNA Biology and School...
Abstract Background Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung (NSCLC) most common type cancer. In traditional anti-cancer therapy, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) have been proven to be beneficial for patients with EGFR mutations. However, wild-type NSCLC were usually not respond EGFR-TKIs. Enhancer zeste homolog 2 (EZH2) a key molecular in PRC2 complex and plays an important role epigenetic regulation...
The long non-coding RNA Hox transcript antisense intergenic (HOTAIR) plays a critical role in tumorigenesis as well drug resistance various cancers.However, the molecular mechanism by which HOTAIR induces gefitinib non-small cell lung cancer is to date unclear.In present study, we revealed that upregulated gefitinib-resistant cells and over-expression of enhances cells.In addition, overexpression promotes cycle progression through epigenetic regulation EZH2/H3K27.Silencing EZH2 either siRNA...