A5100656979- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Macrophage Migration Inhibitory Factor
- BRCA gene mutations in cancer
- Traditional and Medicinal Uses of Annonaceae
- Botanical Studies and Applications
- Traditional Chinese Medicine Analysis
- Phytochemical Studies and Bioactivities
- Abdominal vascular conditions and treatments
- Enzyme Catalysis and Immobilization
- Plant responses to water stress
- Alkaloids: synthesis and pharmacology
- Vibrio bacteria research studies
- Ubiquitin and proteasome pathways
- Plant and animal studies
- Animal Genetics and Reproduction
- Microbial metabolism and enzyme function
- Fungal Biology and Applications
- Connective tissue disorders research
- Phytochemical compounds biological activities
- Insect and Arachnid Ecology and Behavior
- CRISPR and Genetic Engineering
- Cancer-related Molecular Pathways
- Chemical synthesis and alkaloids
University of Kansas Medical Center
2022-2024
Mayo Clinic in Arizona
2020-2023
Mayo Clinic
2020-2022
WinnMed
2020-2022
University of Minnesota Rochester
2022
First Hospital of Xi'an
2022
Tianjin Medical University General Hospital
2021
Zaozhuang Municipal Hospital
2019-2021
Yunnan University
2011
Five Prime Therapeutics (United States)
2006
CDK4 and CDK6 regulate ciliogenesis Hedgehog signaling via their novel substrate SMYD2.
The long non-coding RNA Hox transcript antisense intergenic (HOTAIR) plays a critical role in tumorigenesis as well drug resistance various cancers.However, the molecular mechanism by which HOTAIR induces gefitinib non-small cell lung cancer is to date unclear.In present study, we revealed that upregulated gefitinib-resistant cells and over-expression of enhances cells.In addition, overexpression promotes cycle progression through epigenetic regulation EZH2/H3K27.Silencing EZH2 either siRNA...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder worldwide and progresses to end-stage renal (ESRD). However, its precise mechanism not fully understood. In recent years, epigenetic reprogramming has drawn increasing attention regarding effect on cyst growth. considering complexity of mechanisms broad range alterations components in ADPKD, identifying more specific factors understanding how they are mechanistically linked promote growth relevant for...
ADPKD is a genetic disorder with molecular complexity that remains poorly understood. In this study, we sampled renal cells to construct comprehensive and spatiotemporally resolved gene expression atlas in whole Pkd1 mutant polycystic mouse kidneys at single-cell resolution. We characterized cell diversity identified novel collecting duct (CD) subtypes cystic kidneys. further found CD appear take different fate trajectories, the first most important step might place around day 14 homozygous...
Phytochemical study on the leaves and twigs of afforded new megastigmane diglycoside (6S, 7E, 9R)-6, 9-dihydroxy-4, 7-megastigmadien-3-one-9-O-[α-L-arabinofuranosyl-(l→6)]-β-D-glucopyranoside (1), along with glycosides 9R)-roseoside (2), (7'R, 8'R)- 3, 5'-dimethoxy-9, 9'-dihydroxy-4, 7'-epoxylignan 4'-β-D-glucopyranoside (3), 8'S)-dihydrodehydrodiconifenyl alcohol 9'-O-β-D-xylopyranoside (4) pinoresinol 3-O-β-D-glucopyranoside (5). Their structures were established basis extensive...
Abstract Primary cilia are microtubule-based organelles that play important roles in development and tissue homeostasis. Macrophage migration inhibitory factor (MIF) has long been recognized as a secreted cytokine the pathogenesis of various human diseases, including cancer autosomal dominant polycystic kidney disease (ADPKD). Unlike other cytokines, unique functional characteristics intracellular MIF have emerged. In this study, we show is localized formed ring like structure at proximal...
Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in the PKD1 and PKD2 genes, it characterized renal cyst formation, inflammation fibrosis. Forkhead box protein M1 (FoxM1), a transcription factor of (Fox) super family, has been reported to promote tumor fibrosis many organs. However, role mechanism FoxM1 regulation ADPKD progression still poorly understood. Here, we show that an important regulator growth ADPKD. upregulated cyst-lining epithelial cells Pkd1 mutant...
The primary cilium is a microtubule-based sensory organelle that plays critical role in signaling pathways and cell cycle progression. Defects the structure and/or function of result developmental diseases collectively known as ciliopathies. However, constituents regulatory mechanisms are not fully understood. In recent years, activity epigenetic modifier SMYD3 has been shown to play key regulation whether SMYD3, histone/lysine methyltransferase, contributes ciliogenesis remains unknown....
Astilbin, a dihydroflavonoid compound widely found in plants, exhibits variety of pharmacological activities and biological effects. However, little is known about the metabolism this active vivo, which very helpful for elucidating pharmacodynamic material basis application astilbin.To establish rapid profiling identification method metabolites rat urine, faeces plasma using UHPLC-Q-Exactive mass spectrometer negative ion mode.In study, simple systematic strategy 7 metabolite templates, were...
Abstract Ciliopathies are a group of human diseases that affect the cellular cilia or anchoring structures, bosal bodies, ciliary function. Macrophage migration inhibitory factor (MIF) as an important inflammatory cytokine plays prominent role in pathogenesis various diseases. However, MIF ciliopathies remains elusive. In this study, we show is structure protein basal which forms ring-like at proximal end centrioles to regulate assembly and elongation. Importantly, identify novel...