A5048115276- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Virus-based gene therapy research
- Immune cells in cancer
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Estrogen and related hormone effects
Zhejiang University
2016-2025
Ministry of Education of the People's Republic of China
2023-2024
Zhejiang Cancer Hospital
2012-2024
Children's Hospital of Zhejiang University
2012-2024
Zhejiang Lab
2023-2024
Huazhong University of Science and Technology
2024
Westlake University
2023
Sir Run Run Shaw Hospital
2016-2021
Pharmaceutical Biotechnology (Czechia)
2014
Children's Hospital of Los Angeles
2010-2012
Abstract Ferroptosis is a newly characterized form of regulated cell death mediated by iron-dependent accumulation lipid reactive oxygen species and holds great potential for cancer therapy. However, the molecular mechanisms underlying ferroptosis remain largely elusive. In this study, we define an integrative role DJ-1 in ferroptosis. Inhibition potently enhances sensitivity tumor cells to inducers both vitro vivo. Metabolic analysis metabolite rescue assay reveal that depletion inhibits...
Abstract Yes-associated protein (YAP) and its paralog, transcriptional coactivator with PDZ-binding motif (TAZ), play pivotal roles in promoting the progression of hepatocellular carcinoma. However, regulatory mechanism underpinning aberrant activation YAP/TAZ carcinoma remains unclear. In this study, we globally profiled contribution deubiquitinating enzymes (DUB) to both activity abundance models identified ubiquitin-specific peptidase 10 (USP10) as a potent YAP/TAZ-activating DUB....
Abstract M2 polarization of macrophages is essential for their function in immunologic tolerance, which might promote tumorigenesis. However, the molecular mechanism behind process not fully understood. Given that several lines evidence have suggested long noncoding RNAs (lncRNAs) could be involved regulating immune cell differentiation and function, current study aimed to identify lncRNAs specifically modulate macrophage polarization. By utilizing a series cell-based models, total 25 with...
M2-polarized tumor-associated macrophages (TAM) play a critical role in cancer invasion and metastasis. Here, we report that M2 enhanced metastasis of K7M2 WT osteosarcoma cells to the lungs mice, thus establishing TAMs as therapeutic target for blocking We found all-trans retinoic acid (ATRA) inhibited via inhibiting polarization TAMs. ATRA suppressed IL13- or IL4-induced M2-type macrophages, then migration promoted by vitro reduced number pulmonary metastatic nodes decreased expression...
// Jun Zhang 1,* , Ji Cao Shenglin Ma 2,3 Rong Dong 1 Wen Meng 2 Meidan Ying Qinjie Weng Zibo Chen 5 Jian Qingxia Fang 4 Qiaojun He and Bo Yang Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute Pharmacology Toxicology, College Pharmaceutical Sciences, University, Hangzhou, China Hangzhou First People’s Hospital, Huansha Road, 3 The second Clinical Medical College, Chinese Provincial hospital, Shangtang Materials Science Engineering, Central South University...
The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report platform named Auto-RapTAC. Based on the modular characteristic of molecule, streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed. This facilitates autonomous generation variety PROTACs, each distinct linkers E3...
Aim: Chemotherapy-induced reactive oxygen species (ROS) not only contribute to apoptosis, but also trigger autophagy. Since autophagy is reported protect cancer cells from this weakens the therapeutic effect of chemotherapy. This study aimed at identifying key molecules that determine cellular response ROS and, therefore, provide better strategies increase chemotherapeutic efficiency. Results: Increasing concentrations N-(4-hydroxyphenyl) retinamide (4-HPR)-treatment pushed down apoptosis in...
Metastasis is the leading cause of mortality for human non-small cell lung cancer (NSCLC). However, it difficult to target tumor metastasis because molecular mechanisms underlying NSCLC invasion and migration remain unclear. Methods: GEO data analyses IHC were performed identify that expression level AKR1C1, a member aldo-keto reductase family, was highly elevated in patients with or metastatic foci patients. Functional (in vitro vivo) quantitative genomic preformed confirm pro-metastatic...
Osteosarcoma, one of the most common malignant bone tumours, is generally considered a differentiation disease caused by genetic and epigenetic disruptions in terminal osteoblasts. Novel therapies based on non-cytotoxic induction cell differentiation-responsive pathways could represent significant advance treating osteosarcoma; however, effective pharmaceuticals to induce are lacking. In present study, we investigated effect hyperoside, flavonoid compound, osteoblastic U2OS MG63 osteosarcoma...
Abstract Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, connections between these phenomena are not fully understood. In this study, we define an integrative role for E3 ubiquitin ligase subunit WSB1. primary osteosarcomas, increased levels WSB1 correlated pulmonary potential. RNAi-mediated attenuation or disruption its activity potently suppressed tumor metastasis. Quantitative proteomic and functional analyses...