A5101506972- Heme Oxygenase-1 and Carbon Monoxide
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Autophagy in Disease and Therapy
- Neonatal Health and Biochemistry
- Phytochemical compounds biological activities
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Histone Deacetylase Inhibitors Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Natural Compound Pharmacology Studies
- Retinal Development and Disorders
- Kruppel-like factors research
- Cell death mechanisms and regulation
- Chromosomal and Genetic Variations
- Phytochemicals and Antioxidant Activities
- CRISPR and Genetic Engineering
- Berberine and alkaloids research
- Phytochemistry and Bioactive Compounds
- High Altitude and Hypoxia
Hubei Polytechnic University
2024
Shenzhen Bay Laboratory
2024
Hunan Children's Hospital
2024
Yunnan University of Traditional Chinese Medicine
2013-2023
Yunnan University
2018-2023
National University of Singapore
2016-2022
Yunnan Provincial Department of Education
2022
Yichang Central People's Hospital
2021
Baotou Medical College
2018
Wenzhou Medical University
2010-2016
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction extracellular matrix (ECM). Caveolin-1 (cav-1), principal component caveolae, has been implicated in the regulation numerous signaling pathways biological processes. We observed marked reduction cav-1 expression lung tissues primary from IPF patients compared with controls. also demonstrated that markedly ameliorated bleomycin (BLM)-induced fibrosis, as...
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress and modulates pro-inflammatory cytokines. As the sepsis syndrome results from release of mediators, we postulated that its enzymatic product CO would protect lethality in a murine model sepsis. Mice treated with lethal dose lipopolysaccharide (LPS) subsequently exposed to inhaled had significantly better survival lower serum interleukin (IL)-6 IL-1β levels than their untreated counterparts. In vitro,...
Background Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the regulation of lipid and carbohydrate metabolism. This study aims to test hypothesis that elevated FGF21 concentrations are associated with change renal function presence left ventricular hypertrophy (LVH) different stages chronic kidney disease (CKD) progression. Methodology/Principal Findings 240 subjects including 200 CKD patients (146 outpatients 54 long-term hemodialytic patients) 40 healthy control were...
TFEB (transcription factor EB) is a master regulator of lysosomal biogenesis, function and autophagy. The transcriptional activity mainly controlled by its phosphorylation status mediated the MTOR (mechanistic target rapamycin [serine/threonine kinase]) complex 1 (MTORC1). At present, little known whether other forms posttranslational modifications (PTMs) such as acetylation also affects activity. In this study, we first observed that well-established histone deacetylase inhibitor...
Osteosarcoma, one of the most common malignant bone tumours, is generally considered a differentiation disease caused by genetic and epigenetic disruptions in terminal osteoblasts. Novel therapies based on non-cytotoxic induction cell differentiation-responsive pathways could represent significant advance treating osteosarcoma; however, effective pharmaceuticals to induce are lacking. In present study, we investigated effect hyperoside, flavonoid compound, osteoblastic U2OS MG63 osteosarcoma...
Abstract T lymphocyte activation and proliferation is involved in many pathological processes. We have recently shown that carbon monoxide (CO), an enzymatic product of heme oxyenase-1 (HO-1), confers potent antiproliferative effects airway vascular smooth muscle cells. The purpose this study was to determine whether CO can inhibit then the mechanism by which modulate proliferation. In presence 250 parts per million CO, CD3-activated was, remarkably, inhibited 80% when compared with...
Abstract Cisplatin and other platinum-based compounds are frequently used to treat breast cancer, but their utility is severely compromised by drug resistance. Many genes dictating responsiveness subject pre-mRNA alternative splicing which regulated key kinases such as the serine-arginine protein kinase 1 (SRPK1). However, its contribution resistance remains controversial. In this study, we have identified that Tip60-mediated acetylation of SRPK1 closely associated with chemotherapy...
Cell death-inducingDFF45-like effector (CIDE)-B is a member of the novel family apoptosis-inducing factors that share homology with N-terminal region DFF, DNA fragmentation factor. The molecular mechanism CIDE-B-induced apoptosis unclear. We have shown here CIDE-B protein localized in mitochondria and forms homodimers heterodimers other members. Serial deletion analyses suggest localization signal dimerization interface are overlapped to 30 amino acid residues at C-terminal CIDE-B....
A properly functioning immune system is dependent on programmed cell death/apoptosis at virtually every stage of lymphocyte development and activity. Carbon monoxide (CO), an enzymatic product heme oxyenase-1, has been shown to possess anti-apoptotic effects in a number different model systems. The purpose the present study was expand this knowledge determine role CO well established Fas/CD95-induced apoptosis Jurkat cells, mechanism by which can modulate T-cell apoptosis. Exposure cells...
Since its initial discovery in 1962, Paclitaxel has emerged as a highly esteemed drug the realm of cancer therapy, garnering widespread attention owing to potent anticancer properties. This paper delves into pivotal milestones evolution Paclitaxel, comprehensively outlining historical context, manufacturing methodologies, mode action, and clinical utilization. Originating from bark Pacific yew tree, was initially procured through natural extraction, posing challenges due scarcity raw...
Abstract Natural uranium is a ubiquitous element in the environment, and human exposure to low levels of unavoidable. Several concerns have recently been raised about reproductive effects chronic uranium. Therefore, aim this study was investigate protective effect Nicotinamide mononucleotide（NMN） on exposure-induced testicular sperm function mice. To end, research model established which damage spermatogenic dysfunction were induced adult male mice by intraperitoneal injection two different...
Hyperuricemia is the result of overproduction and/or underexcretion uric acid, and it a well-known risk factor for gout, hypertension, diabetes. However, available drugs hyperuricemia in clinic are limited. Recently, lot research has been conducted order to discover new acid-lowering agents from plants foods. We found that extracts pericarp mangosteen reduced urate. Bioactivity-guided study showed α-mangostin was principal constituent. Herein, we reported first time hypouricemic activities...
PIWI homologs constitute a subclass of the Argonaute family. Traditionally, they have been shown to associate with specific class small RNAs, piRNAs, suppress transposable elements and protect genomic integrity in germ cells. Recent studies imply that proteins may also exert important biological functions somatic contexts, including brain. However, their exact role neural development remains unknown. Hence we investigated whether are involved neuronal differentiation. By using an established...
Halophilic actinomycete strains, IQ-H1T (T = type strain) and IQ-H2, were isolated from extremely saline soil samples in Iraq. Besides morphological properties, strains IQ-H2 have a IV cell wall, PIII phospholipid, menaquinone MK-9 (H4, H6), which are characteristic of Actinopolyspora spp. In addition, both required high concentrations sodium chloride (10 to 15% [wt/vol] 15 25% NaCl, respectively), for optimal growth. However, differed other previously described species the genus cultural,...
Hyperoxia generates an oxidative stress in the mouse lung, which activates major stress-inducible kinase pathways, including c-Jun NH 2 -terminal (JNK). We examined effect of Jnk1 gene deletion on vivo responses to hyperoxia mice. The survival -/- mice was reduced relative wild-type after exposure continuous hyperoxia. - /- displayed higher protein concentration bronchoalveolar lavage (BAL) fluid and increased expression heme oxygenase-1, a gene, 65 h Contrary other markers injury, leukocyte...
Carbon monoxide (CO) is a biologically active molecule produced in the body by stress-inducible enzyme, heme oxygenase. We have previously shown that CO suppresses fibrosis murine bleomycin model. To investigate mechanisms which opposes fibrogenesis, we performed gene expression profiling of fibroblasts treated with transforming growth factor-beta(1) and CO. The most highly differentially expressed categories genes included those related to muscular system development small proline-rich...
Our study aimed at validating the effect of WISP1 on osteoarthritis (OA) and pathway involved in WISP1-induced protection against OA. The expression was measured by immunohistochemical analyses. We found that shown to be upregulated within human OA cartilage compared with controls. related knee severity. rhWISP1 inhibited chondrocyte senescence apoptosis vitro, which reversed αvβ3 antibody PI3K/Akt inhibitor LY294002. overexpression induced injection LiCI could also prevent rat chondrocytes....