A5101955899- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Renal Diseases and Glomerulopathies
- Traditional Chinese Medicine Analysis
- Renal and Vascular Pathologies
- Gout, Hyperuricemia, Uric Acid
- Parathyroid Disorders and Treatments
- Phytochemistry and Biological Activities
- Renal and related cancers
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Drug Transport and Resistance Mechanisms
- Hernia repair and management
- Biomedical Research and Pathophysiology
- Ocular Surface and Contact Lens
- Mesenchymal stem cell research
- Radiopharmaceutical Chemistry and Applications
- Medicinal Plant Pharmacodynamics Research
- Organ Transplantation Techniques and Outcomes
- Pelvic and Acetabular Injuries
National Medical Products Administration
2025
Nanjing Medical University
2025
First Affiliated Hospital of Henan University
2019-2024
Anhui Medical University
2008-2023
Tengzhou Central People's Hospital
2023
Xuzhou Medical College
2004-2023
First Affiliated Hospital of Anhui Medical University
2023
Analysis Group (United States)
2022-2023
Affiliated Hospital of Jiangsu University
2023
Jiangsu University
2023
Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) is currently considered a novel therapeutic strategy for diabetic nephropathy (DN). However, the mechanisms by which UC-MSCs ameliorate renal fibrosis in DN are not well understood. Herein, we firstly investigated effects mouse UC-MSC infusion on kidney structural and functional impairment streptozotocin- (STZ-) induced mice. We found that repeated injection with mUC-MSCs alleviates albuminuria, glomerulus injury, models....
Significance Statement The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. However, clinical significance clearance tubular secretory uncertain. In this prospective cohort study 3416 participants with CKD, authors found that lower clearances six endogenous are associated significantly greater risk CKD progression (defined as a ≥50% decline in eGFR from baseline, initiation maintenance dialysis, or transplantation) and four all-cause mortality...
Catalpol, an iridoid glycoside extracted from Rehmannia glutinosa, has been found to ameliorate diabetic nephropathy (DN), but the mechanism not clarified. Podocyte injury play a key role in pathogenesis of DN. This study mainly investigated protective effect and potential catalpol on podocyte DN vivo vitro. The results indicated that pathological features mice were markedly ameliorated after treatment with catalpol. Moreover, foot process effacement, down-regulation nephrin synaptopodin...
New Findings What is the central question of this study? role long non‐coding RNA X‐inactive specific transcript ( XIST ), which up‐regulated in injured podocytes and membranous nephropathy, pathogenesis nephropathy? main finding its importance? was kidney tissue with nephropathy podocytes. Down‐regulation inhibited podocyte apoptosis. negatively regulated miR‐217, miR‐217 modulated Toll‐like receptor 4. Inhibition suppressed apoptosis induced by angiotensin II via miR‐217. Abstract...
Catalpol, a natural iridoid glycoside in Rehmannia glutinosa, can alleviate proteinuria associated with diabetic nephropathy (DN), however, whether catalpol has protective effect against podocyte injury DN remains unclear. In this study, we used high glucose (HG)-induced model to evaluate the and mechanism of HG-induced injury. Cell viability was determined by 3-(4,5-dimethylthiazolyl-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The levels lactate dehydrogenase (LDH), superoxide...
Background Although proximal tubular secretion is the primary mechanism of kidney drug elimination, current dosing strategies are on basis eGFR. Methods In a dedicated pharmacokinetic study to compare GFR with secretory clearance for predicting we evaluated stable outpatients eGFRs ranging from 21 140 ml/min per 1.73 m 2 . After administering single doses furosemide and famciclovir (metabolized penciclovir), calculated their clearances sequential plasma timed urine measurements....
For patients with colorectal cancer, minimally invasive surgical methods, particularly laparoscopic are now the preferred course of therapy. This research is performed to investigate effects radical resection on cancer. A total 100 cancer treated in our hospital from January 2017 2019 were enrolled. The subjects divided into observation ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>50</mn> </math> ) and control id="M2"> groups surgery laparotomy,...
Although elevated uric acid is associated with obesity and considered a predictor of hypertension, the causal linkage between three metabolic conditions not very clear. We aim to examine whether mediates effects on hypertension development.A total 1984 participants (mean aged 53 years, 62.10% female) repeated measurements obesity, blood pressure, 4 years apart in Gusu cohort were included. first applied cross-lagged panel analysis bidirectional association delineate temporal hyperuricemia....
Visual Abstract Export Background and objectives In autosomal dominant polycystic kidney disease (ADPKD), the GFR often remains normal despite significant nephron loss. Proximal tubular secretory clearance may be reduced in ADPKD before detectable changes GFR. Design, setting, participants, & measurements We used targeted mass spectrometry to quantify solutes from blood urine samples 31 patients with preserved (mean eGFR =111±11 ml/min per 1.73 m2) 25 healthy control individuals as well 95...
The secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function. degree to which secretory solute clearance corresponds with glomerular filtration rate (GFR) and potential metabolic implications net are largely unknown.
To observe the effect of demodex infection on ocular surface changes patients with meibomian gland dysfunction (MGD) and analyze correlation between number surface.Hundred MGD aged 18-70 years who visited dry eye center Shanghai Aier Eye Hospital were recruited. All examined in vivo confocal microscopy to quantify divided them into two groups (demodex negative group positive group) according mites. The subjects underwent questionnaires disease index (OSDI) a series examinations. Parameters...
This study aims to investigate the clinical value of serum Klotho and FGF23 in cardiac valve calcification patients with chronic kidney disease (CKD).In present study, 180 CKD, who were admitted department nephrology our hospital on April 1, 2016 (solstice, 2019), selected as main subjects. According CKD stage, these divided into three groups: CKD2~3 group, CKD4 CKD5 group. In each ultrasound was used evaluate calcification, independent risk factors for analyzed by Logistic regression.The...