A5054629081- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Folate and B Vitamins Research
- Renal and related cancers
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Ferroptosis and cancer prognosis
- Genetic Syndromes and Imprinting
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Systemic Lupus Erythematosus Research
- Anesthesia and Neurotoxicity Research
- Muscle and Compartmental Disorders
- RNA Interference and Gene Delivery
- Renal cell carcinoma treatment
- Neonatal and fetal brain pathology
- Complement system in diseases
- Family Caregiving in Mental Illness
- Biomarkers in Disease Mechanisms
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2024
Wenzhou Medical University
2008-2023
Nanfang Hospital
2016
First Affiliated Hospital of Wenzhou Medical University
2010
Abstract Currently, there is a lack of effective therapeutic approaches to the treatment chronic kidney disease (CKD) with irreversible deterioration renal function. This study aimed investigate ability mutant FGF1 (FGF1 ΔHBS , which has reduced mitogenic activity) alleviate CKD and its associated mechanisms. We found that exhibited much weaker activity than wild-type WT ) in tissues. RNA-seq analysis revealed inhibited oxidative stress inflammatory signals mouse podocytes challenged high...
New Findings What is the central question of this study? role long non‐coding RNA X‐inactive specific transcript ( XIST ), which up‐regulated in injured podocytes and membranous nephropathy, pathogenesis nephropathy? main finding its importance? was kidney tissue with nephropathy podocytes. Down‐regulation inhibited podocyte apoptosis. negatively regulated miR‐217, miR‐217 modulated Toll‐like receptor 4. Inhibition suppressed apoptosis induced by angiotensin II via miR‐217. Abstract...
Acute tubular necrosis (ATN), a leading cause of acute kidney injury (AKI), is associated with decreased survival and increased progression chronic disease. A barrier to improving the clinical outcomes incomplete understanding pathogenesis AKI. Our objective test hypothesis that intrarenal renin-angiotensin system (RAS) overexpressed in patients ATN could be an indicator severity.A transversal study was conducted biopsy-proven ATN. Intrarenal expression angiotensinogen angiotensin II,...
An association between serum complement levels and poor renal prognosis in patients with immunoglobulin A nephropathy (IgAN) remains controversial. We conducted a retrospective study examining the relationship IgAN. Between 2009 2013, biopsy-confirmed IgAN were identified from Second Affiliated Hospital of Wenzhou Medical College, China, various parameters documented during follow-up until 2015. The definition primary endpoint was decrease estimated glomerular filtration rate (eGFR) more...
Activation of NLRP3 inflammasome in macrophages contributes greatly to IgA nephropathy (IgAN) progression. This study intended investigate the underlying mechanism NOD-like receptor family, pyrin domain containing 3 (NLRP3) activation development IgAN.We examined expression levels colorectal neoplasia differentially expressed (CRNDE), inflammasome-related proteins peripheral blood mononuclear cells (PBMCs) and J774A.1 detected inflammatory cytokine serum IgAN patients cell supernatants vitro...
Emerging research has substantiated that pyroptosis-related biomarkers were mightily related to the clinical outcome of patients with clear cell renal carcinoma (ccRCC). However, a single-gene biomarker's moderate predictive power is insufficient, and more accurate prognostic models are urgently needed. We conducted this investigation in order develop robust gene signature for use risk stratification survival prognosis colorectal cancer. downloaded transcriptomic data information ccRCC from...
Objective Flares of lupus nephritis (LN) are frequent and associated with impaired renal prognosis. One major management obstacle in LN flare is the lack effective methods to identify at‐risk patients earlier their disease course. This study was undertaken test utility measurement urinary matrix metalloproteinase 7 (MMP‐7) for dynamic surveillance activity prediction flares LN. Methods A prospective, 2‐stage cohort performed Urinary MMP‐7 levels at time biopsy were evaluated 154 newly...
The early prediction of renal outcomes in patients with idiopathic membranous nephropathy (iMN) remains challenging. present retrospective study evaluated iMN confirmed by biopsy. An optimized Cox regression model and a nomogram were constructed for the outcomes. A total 141 who met inclusion criteria study. In 18 (12.8%) eventually progressed to endpoint, 6 whom developed end-stage disease, one patient died during follow-up. demonstrated that 24-h proteinuria [hazard ratio (HR) 1.24; 95%...
Recent advancements in computer vision within the field of artificial intelligence (AI) have made significant inroads into medical domain. However, application AI for classifying renal pathology remains challenging due to subtle variations multiple pathological classifications. Vision Transformers (ViT), an adaptation Transformer model image recognition, demonstrated superior capabilities capturing global features and providing greater explainability. In our study, we developed a ViT using...
Obesity is positively linked to multiple metabolic complications including renal diseases. Several studies have demonstrated Kruppel-like factor 4 (KLF4) participated in dysfunction and structural disorders acute kidney injuries, but whether it affected the process of chronic diseases was unknown. Therefore, present study disclose role KLF4 dietary-induced injuries underlying mechanisms obesity. Through utilizing high-fat diet-fed mice human biopsies, we provided physiological roles...
Drugs for metabolic diseases usually require systemic administration and act on multiple tissues, which may produce some unpredictable side effects. There have been many successful studies targeted drugs, especially antitumor drugs. However, there is still little research disease drugs targeting specific tissues. Fibroblast growth factor 1 (FGF1) a potential therapy type 2 diabetes (T2D) without the risk of hypoglycemia. major impediment to clinical application FGF1 its mitogenic potential....
One of the major challenges in improving management antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) is lack a disease-specific indicator for histological lesions and disease activity. Here we tested utility urinary angiotensinogen (UAGT) as biomarker renal activity ANCA-GN.A prospective, two-stage cohort study was performed ANCA-GN patients. In Stage I, UAGT measured at time biopsy 69 patients from two centers (test set) 25 other (validation set). II, monitored 50...
Aims: A noninvasive indicator of renal histological lesions and disease activity in lupus nephritis (LN) is needed for timely targeted treatment before overt injury. Here, we tested the utility urinary angiotensinogen (UAGT) to predict LN. Results: prospective, three-stage study was performed patients with In stage I, UAGT measured 140 newly diagnosed LN patients. significantly increased patients, correlating well kidney expression activity. Patients class IV exhibited highest compared other...
The aim of our study was to evaluate the effect lycopene on antioxidant status and level homocysteine (HCY) in dialysis patients receiving intravenous iron therapy. A total 60 hemodialysis therapy were randomly assigned treatment group control group. Patients (n = 30) received oral iron, while only At initiation study, oxidant indexes HCY concentration tested. After 8 weeks, all laboratory variables repeatedly evaluated. no significant differences found stress between two groups. levels...
Objective To evaluate the relationship between serum magnesium and coronary artery calcification (CAC) their associated factors. Methods 131 patients with chronic kidney disease on regular hemodialysis (HD) were recruited into this study from December 2014 to 2015 in our center. Demographic clinical data of selected collected. Serum fibroblast growth factor 23 (FGF-23) level was quantified by enzyme linked immunosorbent assay(ELISA). Quantification score (CACs) determined multi-slice...
Objective To investigate the factors correlated to coronary artery calcification(CAC) in maintenance hemodialysis (MHD) patients. Methods This study included 132 patients(54 females, 78 males), aged 26-94 years, who were on for 10-204 months(median dialysis duration 51.00 months). The parameters including calcium, phosphorus, parathyroid hormone, total cholesterol, low density lipoprotein, triglycerides, C-reactive protein (CRP), klotho, and so assessed. Quantification of CAC was...
Objective To explore the association between serum FGF23 and Klotho protein, bone mineral density in maintenance hemodialysis (MHD) patients. Methods A total of 125 MHD patients admitted Hospital January 2015 November was enrolled. Their densities femur neck lumbar spine were studied by dual-energy X-ray absorptiometry. These divided into three groups as normal, osteopenic osteoporotic, according to World Health Organization criteria based on T scores. Levels FGF23, protein...