A5012836038- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Bioactive Natural Diterpenoids Research
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Plant-based Medicinal Research
- Plant Disease Resistance and Genetics
- Microbial Community Ecology and Physiology
- Circular RNAs in diseases
- Chromosomal and Genetic Variations
- Protist diversity and phylogeny
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Genetic diversity and population structure
- interferon and immune responses
- Parasitic Infections and Diagnostics
- CRISPR and Genetic Engineering
- Natural Compounds in Disease Treatment
- Amphibian and Reptile Biology
- Mycorrhizal Fungi and Plant Interactions
- RNA Interference and Gene Delivery
- Evolution and Paleontology Studies
- Marine Sponges and Natural Products
Sun Yat-sen University
2016-2025
Shanghai University of Traditional Chinese Medicine
2025
Shanghai East Hospital
2025
Guangdong Province Women and Children Hospital
2023
Institute of Genetics and Developmental Biology
2018
Ministry of Education of the People's Republic of China
2008-2017
Guangzhou Experimental Station
2014
Chinese Academy of Sciences
2009
Center for Excellence in Molecular Cell Science
2009
Shanghai Institutes for Biological Sciences
2009
Although microRNAs (miRNAs), other non-coding RNAs (ncRNAs) (e.g.lncRNAs, pseudogenes and circRNAs) competing endogenous (ceRNAs) have been implicated in cell-fate determination various human diseases, surprisingly little is known about the regulatory interaction networks among multiple classes of RNAs.In this study, we developed starBase v2.0 (http://starbase.sysu.edu.cn/) to systematically identify RNA-RNA protein-RNA from 108 CLIP-Seq (PAR-CLIP, HITS-CLIP, iCLIP, CLASH) data sets...
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It model system for studying chloroplast-based photosynthesis, as well the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited common ancestor animals, but lost in plants. We sequenced ∼120-megabase nuclear genome performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated...
MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (sRNAs) that regulate gene expression by targeting messenger RNAs. However, assigning miRNAs to their regulatory target genes remains technically challenging. Recently, high-throughput CLIP-Seq and degradome sequencing (Degradome-Seq) methods have been applied identify the sites Argonaute interaction miRNA cleavage sites, respectively. In this study, we introduce a novel database, starBase (sRNA Base), which developed...
Abstract Background Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes mammals and plants. However, the systematic examination lncRNAs plants lags behind that mammals. Recently, have been identified Arabidopsis wheat; however, no screening potential has reported for rice genome. Results In this study, we perform whole transcriptome strand-specific RNA sequencing (ssRNA-seq) samples from anthers, pistils, seeds 5 days after pollination shoots 14...
Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piRNAs responsible for silencing retrotransponsons and the second wave predominantly derived from nontransposon intergenic regions pachytene spermatocytes, but function these largely unknown. Here, we report involvement instructing massive mRNA elimination mouse elongating spermatids (ES). We demonstrate that a piRNA-induced complex (pi-RISC) containing murine PIWI (MIWI) deadenylase CAF1...
More than 100 distinct chemical modifications to RNA have been characterized so far.However, the prevalence, mechanisms and functions of various remain largely unknown.To provide transcriptome-wide landscapes modifications, we developed RMBase v2.0 (http:// rna.sysu.edu.cn/rmbase/), which is a comprehensive database that integrates epitranscriptome sequencing data for exploration post-transcriptional RNAs their relationships with miRNA binding events, disease-related singlenucleotide...
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of important in eukaryotes. Although these have been implicated organismal development various human diseases, surprisingly little is known about their transcriptional regulation. Recent advances chromatin immunoprecipitation with next-generation DNA sequencing (ChIP-Seq) provided methods detecting transcription factor binding sites (TFBSs) unprecedented sensitivity. In this study, we describe ChIPBase...
The abnormal transcriptional regulation of non-coding RNAs (ncRNAs) and protein-coding genes (PCGs) is contributed to various biological processes linked with human diseases, but the underlying mechanisms remain elusive. In this study, we developed ChIPBase v2.0 (http://rna.sysu.edu.cn/chipbase/) explore regulatory networks ncRNAs PCGs. has been expanded ∼10 200 curated ChIP-seq datasets, which represent about 20 times expansion when comparing previous released version. We identified...
Background MicroRNAs (miRNAs) are ∼22-nt small non-coding regulatory RNAs that have generally been considered to regulate gene expression at the post-transcriptional level in cytoplasm. However, recent studies reported some miRNAs localize and function nucleus. Methodology/Principal Findings To determine number of localized nucleus, we systematically investigated subcellular distribution (sRNAs) by independent deep sequencing sequenced nuclear cytoplasmic pools 18- 30-nucleotide sRNAs from...
MicroRNA-122 (miR-122) is a liver-specific microRNA whose expression specifically turned on in the mouse liver during embryogenesis, thus it expected to be involved development. However, role of miR-122 development and its potential underlying mechanism remain unclear. Here, we show that closely correlated with four liver-enriched transcription factors (LETFs)—hepatocyte nuclear factor (HNF) 1α, HNF3β, HNF4α, CCAAT/enhancer-binding protein (C/EBP) α—in livers developing embryos human...
Small non-coding RNAs (e.g. miRNAs) and long lincRNAs circRNAs) are emerging as key regulators of various cellular processes. However, only a very small fraction these enigmatic have been well functionally characterized. In this study, we describe deepBase v2.0 (http://biocenter.sysu.edu.cn/deepBase/), an updated platform, to decode evolution, expression patterns functions diverse ncRNAs across 19 species. has provide the most comprehensive collection ncRNA-derived generated from 588...
Summary Plant laccase ( LAC ) enzymes belong to the blue copper oxidase family and polymerize monolignols into lignin. Recent studies have established involvement of micro RNA s in this process; however, physiological functions regulation plant laccases remain poorly understood. Here, we show that a gene, 4 , regulated by miR397b, controls both lignin biosynthesis seed yield Arabidopsis. In transgenic plants, overexpression miR397b OX miR397b) reduced deposition. The secondary wall thickness...
RNA-binding proteins (RBPs) regulate the expression of thousands transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about dysregulation RBPs at genomic level cancers. Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), mutation profiles 1,542 ∼7,000 clinical specimens across 15 cancer types. We identified markedly dysregulated found that downregulation was a predominant pattern cancer. Combined with...
Although more than 100 different types of RNA modifications have been characterized across all living organisms, surprisingly little is known about the modified positions and their functions. Recently, various high-throughput modification sequencing methods developed to identify diverse post-transcriptional molecules. In this study, we a novel resource, RMBase (RNA Modification Base, http://mirlab.sysu.edu.cn/rmbase/), decode genome-wide landscape identified from data generated by 18...
Twenty‐two conserved miRNAs were chosen to investigate the expression pattern in response phytohormone treatments, which effects of five classic plant hormone stresses surveyed Oryza sativa . The results showed that 11 found be dysregulated by one or more treatments. target genes these validated vivo and their profiling revealed. We also analyzed promoter regions 22 for phytohormone‐responsive elements existence provided further evidences supporting our results. These findings enable us role...
Background Recent reports have indicated that microRNAs (miRNAs) play a critical role in malignancies, and regulations the progress of adult leukemia. The miRNAs pediatric leukemia still needs to be established. purpose this study was investigate aberrantly expressed acute demonstrate miRNA patterns are pediatric-specific prognostic parameter-associated. Methodology/Principal Findings A total 111 bone marrow samples, including 99 patients 12 normal donors, were enrolled study. Of those 36 7...
Establishing the relationships among modern amphibians (lissamphibians) and their ancient relatives is necessary for our understanding of early tetrapod evolution. However, phylogeny still intractable because highly specialized anatomy poor fossil record lissamphibians. Paleobiologists are not sure whether lissamphibians monophyletic or polyphyletic, which group (temnospondyls lepospondyls) most closely related to them. In an attempt address these problems, eight mitochondrial genomes living...
We sequenced 15 complete mitochondrial genomes and performed comprehensive molecular phylogenetic analyses to study the origin phylogeny of Hynobiidae, an ancient lineage living salamanders. Our show that Hynobiidae is a clade with well resolved relationships, our results contrast morphology-based hypothesis. These salamanders have low vagility are limited in their distribution primarily by deserts, mountains, oceans. analysis suggests relationships among hynobiids been shaped geography....
Multidrug resistance (MDR) and disease relapse are challenging clinical problems in the treatment of leukaemia. Relapsed is frequently refractory to chemotherapy exhibits multiple drug resistance. Therefore, it important identify mechanism by which cancer cells develop In this study, we used microRNA (miRNA) microarray qRT-PCR approaches investigate expression miRNAs three leukaemia cell lines with different degrees doxorubicin (DOX) compared their parent line, K562. The miR-331-5p miR-27a...