A5040225994- Advanced biosensing and bioanalysis techniques
- Advanced Radiotherapy Techniques
- Biosensors and Analytical Detection
- Glioma Diagnosis and Treatment
- Chromosomal and Genetic Variations
- RNA regulation and disease
- Photonic Crystals and Applications
- Advanced Biosensing Techniques and Applications
- Brain Metastases and Treatment
- Ferroelectric and Piezoelectric Materials
- Microfluidic and Capillary Electrophoresis Applications
- MicroRNA in disease regulation
- Acoustic Wave Resonator Technologies
- Microfluidic and Bio-sensing Technologies
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Photonic and Optical Devices
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Molecular Biology Techniques and Applications
- Management of metastatic bone disease
- Plasma Diagnostics and Applications
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
China Academy of Railway Sciences
2025
Guangxi University
2021-2025
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Lanzhou Jiaotong University
2025
China University of Petroleum, East China
2025
Chinese Academy of Geological Sciences
2025
Nanjing Surveying and Mapping Research Institute (China)
2024
Shanghai First Maternity and Infant Hospital
2023-2024
Nanjing Tech University
2022-2024
Spermatogenesis in mammals is characterized by two waves of piRNA expression: one corresponds to classic piRNAs responsible for silencing retrotransponsons and the second wave predominantly derived from nontransposon intergenic regions pachytene spermatocytes, but function these largely unknown. Here, we report involvement instructing massive mRNA elimination mouse elongating spermatids (ES). We demonstrate that a piRNA-induced complex (pi-RISC) containing murine PIWI (MIWI) deadenylase CAF1...
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage transposon-derived transcripts. As many piRNAs appear to have the capacity target diverse mRNAs, raises intriguing possibility may act extensively as siRNAs degrade specific mRNAs. To directly test hypothesis, we compared mouse PIWI (MIWI)-associated with experimentally identified cleaved mRNA fragments from testes, and...
Chronic stress is considered to be a major risk factor in the development of psychopathological syndromes humans. Cognitive impairments and long-term potentiation (LTP) are increasingly recognized as components depression, anxiety disorders other stress-related chronic psychological illnesses. It seems timely systematically study potentially underlying neurobiological mechanisms altered cognitive synaptic plasticity course stress. In present study, rat model unpredictable (CUS) induced...
Oxidized low‑density lipoprotein (ox‑LDL)‑induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis. Salidroside can alleviate atherosclerosis attenuate cell injury induced by ox‑LDL. However, mechanisms involved in this process are not fully understood. Therefore, purpose present study was investigate role adenosine monophosphate‑activated protein kinase (AMPK)/sirtuin (SIRT)1 pathway protection salidroside against ox‑LDL‑induced human umbilical vein cells...
The gut microbiome has been recognized as a significant contributor to primary hepatocellular carcinoma (HCC), with mounting evidence indicating associations between bacterial components and cancers of the digestive system.Here, characterize signature in patients HCC assess diagnostic potential taxa for HCC, 21 healthy first-degree relatives (control group) were enrolled this study. Bacterial DNA fecal samples was quantified by 16S rRNA gene sequencing. We found that 743 operational...
Gastric cancer (GC) has significant morbidity and mortality worldwide especially in China. Its molecular pathogenesis not been thoroughly elaborated. The acknowledged biomarkers for diagnosis, prognosis, recurrence monitoring treatment are lacking. Proteins from matched pairs of human GC adjacent tissues were analyzed by a coupled label-free Mass Spectrometry (MS) approach, followed functional annotation with software analysis. Nano-LC-MS/MS, quantitative real-time polymerase chain reaction...
Accurate identification and localisation of brain tumours from medical images remain challenging due to tumour variability structural complexity. Convolutional Neural Networks (CNNs), particularly ResNet Unet, have made significant progress in image processing, offering robust capabilities for segmentation. However, limited research has explored their integration with human-computer interaction (HCI) enhance usability, interpretability, clinical applicability. This paper introduces...
Inverse opals (IOs) exhibit attractive optical properties and high interconnected porosity; however, the large-area fabrication of continuously ordered IOs remains challenging. This study presents a method for preparing crack-free IO hydrogel films using microfluidic chip. Through "wet infiltration" technique, drying process template is eliminated, thereby avoiding dense cracks that result from particle shrinkage. The fabricated achieve long-range order with lateral dimensions 1 × 1.2 cm2...
The shale reservoir serves as the primary driver of global oil and gas production growth. However, during exploitation these reservoirs, frequent instability in formations often leads to complex situations significant non-productive time. underlying mechanisms formation are not yet fully understood. Shale's distinctive transverse isotropy, resulting from its depositional processes, differentiates it other lithologies. To explore instability, this study performed triaxial compression...
We report a simple, universal method for forming high surface coverage SAMs on ferromagnetic thin (≤100 nm) films of Ni, Co, and Fe. Unlike previous reports, our technique is broadly applicable to different types types. Our data constitutes the first comprehensive examination SAM formation three using two surface-binding chemistries (thiol isocyanide) under preparation conditions: (1) electroreduced newly developed electroreduction approach, (2) freshly evaporated surfaces in glovebox, (3)...
Mitigating non-specific adsorption (NSA) occurring on the surface of microfluidic devices plays a critical role in detection early protein biomarkers for clinical diagnosis. Surface-modified methods commonly used formation channels include BSA coating, PEG grafting, and Plasma cleaning. The composition microstructure PMMA surfaces were characterized by Fourier transfer infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), water contact angles (CA), atomic force (AFM)...