A5102745121- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Nuts composition and effects
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
Tongji University
2019
Tongji Hospital
2019
University of Toronto
2018
Abstract Long noncoding RNAs (lncRNAs) CASC11 is an oncogenic lncRNA in gastric cancer and colorectal cancer. Our study aimed to investigate the role of bladder In this we showed that plasma was upregulated, while miRNA‐150 downregulated patients with early‐stage than healthy controls. Altered expression separated from inversely correlated cance but not Overexpression mediated inhibition cells, overexpression did significantly alter expression. promoted, inhibited cell proliferation. also...
TFEB (transcription factor EB) is a master regulator of lysosomal biogenesis, function and autophagy. The transcriptional activity mainly controlled by its phosphorylation status mediated the MTOR (mechanistic target rapamycin [serine/threonine kinase]) complex 1 (MTORC1). At present, little known whether other forms posttranslational modifications (PTMs) such as acetylation also affects activity. In this study, we first observed that well-established histone deacetylase inhibitor...