A5101413298- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- HIV-related health complications and treatments
- Natural Antidiabetic Agents Studies
- Child and Adolescent Psychosocial and Emotional Development
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Metabolism, Diabetes, and Cancer
- Hormonal and reproductive studies
- Asthma and respiratory diseases
- Pancreatic function and diabetes
- Prostate Cancer Treatment and Research
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Substance Abuse Treatment and Outcomes
- Cardiovascular Function and Risk Factors
- Folate and B Vitamins Research
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2025
Guangxi Medical University
2012-2024
Wannan Medical College
2023
Fudan University
2019-2022
Tumor Hospital of Guangxi Medical University
2019-2022
Taizhou Municipal Hospital
2021
Texas A&M Health Science Center
2015-2020
Guangxi Center for Disease Prevention and Control
2020
Southeast University
2012-2018
King's College London
2006-2018
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction extracellular matrix (ECM). Caveolin-1 (cav-1), principal component caveolae, has been implicated in the regulation numerous signaling pathways biological processes. We observed marked reduction cav-1 expression lung tissues primary from IPF patients compared with controls. also demonstrated that markedly ameliorated bleomycin (BLM)-induced fibrosis, as...
The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), rythmicity sleeping disturbances. A recent study has reported that polymorphism (rs1801260) at 3'-untranslated region CLOCK is associated with adult ADHD. To investigate association ADHD, two samples ADHD...
Fifteen compounds, which included six chiral lignans and nine phenolic glycosides, were separated from the butanol fraction of Averrhoa carambola L. root identified. All namely 3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside, benzyl-1-O-β-D-glucopyranoside, (+)-5'-methoxyisolariciresinol 3α-O-β-D-gluco-pyranoside, (+)-isolariciresinol 3α-O-β-D-glucopyranoside, koaburaside, (+)-lyoniresinol (-)-lyoniresinol (-)-5'-methoxyisolariciresinol (-)-isolariciresinol 3,5-dimethoxy-4-hydroxyphenyl...
Polydatin (PD), a resveratrol glycoside, has been shown to protect renal function in diabetic nephropathy (DN), but the underlying molecular mechanism remains unclear. This study demonstrates that PD stabilize mitochondrial morphology and attenuate malfunction both KKAy mice hyperglycemia (HG)‐induced MPC5 cells. We use Western blot analysis demonstrate reversed podocyte apoptosis induced by HG via suppressing dynamin‐related protein 1 (Drp1). effect may depend on ability of inhibit...
Childhood maltreatment is associated with attention deficits. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA, FKBP5) interaction on functional brain connectivity during sustained in medication/drug-free adolescents. Functional was compared, using generalised psychophysiological (gPPI) analysis magnetic resonance imaging (fMRI) data, between 21 age-and gender-matched adolescents exposed to severe 27 healthy controls, while they performed a parametrically modulated...
We examined two potential biomarkers of brain damage in hypoxic-ischemic encephalopathy (HIE) neonates: glial fibrillary acidic protein (GFAP; a marker gliosis) and ubiquitin C-terminal hydrolase L1 (UCH-L1; neuronal injury). hypothesized that the would be measurable cord blood healthy neonates could serve as normative reference for injury HIE infants. further higher levels detected serum samples correlate with on magnetic resonance imaging (MRI) later developmental outcomes.?Serum UCH-L1...
Abstract There is great interest in blood-based markers of Alzheimer’s disease (AD), especially its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential AD. We also characterise confounding by genetics and the effect on blood general. Panel-based proteomics was performed using SOMAscan samples from TwinsUK subjects who are asymptomatic for AD, measuring level 1129 proteins. Protein were compared 10-year change CANTAB-paired associates...
Abstract Brain‐derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement BDNF attention‐deficit hyperactivity disorder (ADHD). This study investigated two common variants (Val66Met, C270T) samples ADHD probands from United Kingdom (n = 180) and Taiwan 212). We found increased transmission C allele C270T Taiwanese (TDT: χ 2 6.78, P 0.009) pooled together 7.24, 0.007). No association was between Val66Met...
Purpose The goal of this study was to determine the impact age, gender, and race on prevalence severity hearing loss in elder adults, aged 72–96 years, after accounting for income, education, smoking, clinical subclinical cardiovascular disease. Methods Air-conduction thresholds standard extended high-frequency pure-tones were obtained from a cohort 548 (out 717) elderly adults (ages years) who recruited during Year 11 visit (1999–2000) Cardiovascular Health Study (CHS) at Pittsburgh,...
Background. What determines inter-individual variability to impairments in behavioural control that may underlie road-traffic accidents, and impulsive violent behaviours occurring under the influence of cannabis, most widely used illicit drug worldwide? Method. Employing a double-blind, repeated-measures design, we investigated genetic neural basis variable sensitivity cannabis-induced dyscontrol healthy occasional cannabis users. Acute oral challenge with placebo or Δ 9...
Abstract Pancreatic β cell damage is one of the crucial factors responsible for development type 2 diabetes mellitus (T2DM). Previous studies have suggested that puerarin (PR) could regulate activities mitochondrial respiratory chain complex in diabetic nephropathy (DN); however, whether PR can inhibit pancreatic β-cell apoptosis T2DM remains to be elucidated. In present study, mice induced by high-fat diet and streptozotocin (STZ) injection were used as a working model investigate mechanism...
Autophagy is the main protective mechanism against aging in podocytes, which are terminally differentiated cells that have a very limited capacity for mitosis and self-renewal. Here, streptozotocin-induced DN C57BL/6 mouse model was used to investigate effects of puerarin on modulation autophagy under conditions associated with endoplasmic reticulum stress (ERS). In addition, this study aimed identify potential underlying molecular mechanisms.DN induced by streptozotocin (150 mg/kg)...
Abstract The norepinephrine system is known to play a role in attentional and cognitive‐energetic mechanisms thought be important attention deficit hyperactivity disorder (ADHD). Stimulant medications are alter the activity of as well dopamine synapse highly selective reuptake inhibitor, atomoxetine, an effective treatment for ADHD symptoms. This study set out investigate whether common polymorphisms within transporter gene (NET1) associated with DSM‐IV combined subtype, using sample that...
HIV infection and normal aging share immune inflammatory changes that result in premature non-communicable diseases (NCDs), but the exact pathophysiology is not yet uncovered. We identified common metabolic pathways underlying various NCDs treated infection.We performed untargeted metabolomics including 87 HIV-negative (-) controls (NCs), HIV-positive (+) NCs, 148 HIV+ subjects with only one type of NCDs, namely, subclinical carotid atherosclerosis, neurocognitive impairment (NCI), liver...
Abstract Background and purpose Diabetic nephropathy (DN) is an important cause of end-stage renal disease, with podocyte injury as the main feature. Pyroptosis plays a non-negligible role in process diabetic nephropathy. Puerarin (PR) treatment has great potential, but mechanism not very clear. This article aims to study protective effect puerarin on DN. Methods Streptozotocin (STZ)-induced C57 BL/6J mouse model DN was given PR, Necrosulfomide (NSA), Nigericin for 12 weeks; A 60 mM high...
Perchlorates, nitrates, and thiocyanates constitute environmental endocrine disruptors; however, health damage caused by absorption through the respiratory tract remains poorly studied. We investigated effects of inhalation these pollutants on thyroid function structure serum metabolomics in pregnant rats. established a Sprague-Dawley rat model exposed to perchlorate, nitrate, thiocyanate at different gestational stages compared maternal levels, foetal development, morphology, pathological...