A5084314803- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Mental Health Treatment and Access
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Music Perception
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Neural dynamics and brain function
- Neurological disorders and treatments
- Neurobiology of Language and Bilingualism
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Psychiatric care and mental health services
- Fetal and Pediatric Neurological Disorders
King's College London
2016-2025
Warneford Hospital
1997-2025
University of Oxford
1997-2025
Oxford Health NHS Foundation Trust
2023-2025
National Institute for Health Research
2016-2025
South London and Maudsley NHS Foundation Trust
2016-2025
Oxford BioMedica (United Kingdom)
2023-2025
Wellcome Centre for Integrative Neuroimaging
2023-2025
Centro de Investigación Biomédica en Red de Salud Mental
2020-2025
MRC Brain Network Dynamics Unit
2025
Watching a speaker’s lips during face-to-face conversation (lipreading) markedly improves speech perception, particularly in noisy conditions. With functional magnetic resonance imaging it was found that these linguistic visual cues are sufficient to activate auditory cortex normal hearing individuals the absence of sounds. Two further experiments suggest cortical areas not engaged when an individual is viewing nonlinguistic facial movements but appear be activated by silent meaningless...
Context: A major limitation on the development of biomarkers and novel interventions for schizophrenia is that itspathogenesisisunknown.Althoughelevatedstriataldopamine activity thought to be fundamental schizophrenia, it unclear when this neurochemical abnormality develops in relation onset illness how relates symptoms neurocognitive impairment seen individuals with prodromal schizophrenia.Objectives: To determine whether striatal dopamine function elevated before psychosis assess...
Perceptions of speech in the absence an auditory stimulus (auditory verbal hallucinations) are a cardinal feature schizophrenia. Functional neuroimaging provides powerful means measuring neural activity during hallucinations, but results from previous studies have been inconsistent. This may reflect acquisition small numbers images each subject and confounding effects patients actively signaling when hallucinations occur.We examined 6 with schizophrenia who were experiencing frequent using...
Objective: Research in both animals and humans indicates that cannabidiol (CBD) has antipsychotic properties. The authors assessed the safety effectiveness of CBD patients with schizophrenia. Method: In an exploratory double-blind parallel-group trial, schizophrenia were randomized a 1:1 ratio to receive (1000 mg/day; N=43) or placebo (N=45) alongside their existing medication. Participants before after treatment using Positive Negative Syndrome Scale (PANSS), Brief Assessment Cognition...
Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis, has anxiolytic properties. However, no study to date investigated the effects this compound on pathological anxiety its underlying brain mechanisms. The aim present was investigate in patients with generalized social disorder (SAD) using functional neuroimaging. Regional cerebral blood flow (rCBF) at rest measured twice (99m)Tc-ECD SPECT 10 treatment-naïve SAD. In first session, subjects were given an...
Psychosis is a heterogeneous psychiatric condition for which multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength evidence associations between each factor psychotic disorders whilst controlling several biases. The Web Knowledge database was searched identify systematic reviews meta‐analyses observational studies examined socio‐demographic, parental, perinatal, later or antecedents disorders, included comparison group healthy...
There is growing interest in the complex topology of human brain functional networks, often measured using resting-state MRI (fMRI). Here, we used a meta-analysis large primary literature that fMRI or PET to measure task-related activation (>1,600 studies; 1985-2010). We estimated similarity (Jaccard index) patterns across experimental tasks between each pair 638 regions. This continuous coactivation matrix was build weighted graph characterize network topology. The modular, with occipital,...
Movement-related effects in realigned fMRI timeseries can be corrected by regression on linear functions of estimated positional displacements an individual subject's head during image acquisition. However, this entails biased (under)estimation the experimental effect whenever subject motion is not independent input function. Methods for diagnosing such stimulus-correlated (SCM) are illustrated application to data acquired from 5 schizophrenics and normal controls periodic performance a...
Regional cerebral blood flow was measured with H 2 15 O positron emission tomography in four patients obsessive–compulsive disorder. Patients were scanned on 12 occasions the same session, each scan paired brief exposure to one of a hierarchy contaminants that elicited increasingly intense urges ritualise. The relationship between symptom intensity and regional (rCBF; an index neural activity) subsequently examined group individual patients. showed significant positive correlations right...
<h3>Context</h3> Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. <h3>Objective</h3> To investigate the 2 main psychoactive constituents of<i>Cannabis sativa</i>(Δ9-tetrahydrocannabinol [Δ9-THC] cannabidiol [CBD]) on regional brain function during emotional processing. <h3>Design</h3> Subjects were studied 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces...