A5060026865- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- COVID-19 and Mental Health
- Psychotherapy Techniques and Applications
- Autism Spectrum Disorder Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neural and Behavioral Psychology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent and Pediatric Healthcare
- Advanced MRI Techniques and Applications
- Psychiatric care and mental health services
- Long-Term Effects of COVID-19
King's College London
2016-2025
University of Pavia
2015-2025
South London and Maudsley NHS Foundation Trust
2016-2025
National Institute for Health Research
2017-2025
Ludwig-Maximilians-Universität München
2023-2025
National Health Service
2016-2025
NIHR Maudsley Biomedical Research Centre
2018-2025
Italian Society of Physiotherapy
2022-2025
NIHR Maudsley Dementia Biomedical Research Unit
2018-2025
King's College School
2023-2025
Objective Evidence syntheses such as systematic reviews and meta-analyses provide a rigorous transparent knowledge base for translating clinical research into decisions, thus they represent the basic unit of in medicine. Umbrella are previously published or meta-analyses. Therefore, one highest levels evidence synthesis currently available, becoming increasingly influential biomedical literature. However, practical guidance on how to conduct umbrella is relatively limited. Methods We present...
Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis, has anxiolytic properties. However, no study to date investigated the effects this compound on pathological anxiety its underlying brain mechanisms. The aim present was investigate in patients with generalized social disorder (SAD) using functional neuroimaging. Regional cerebral blood flow (rCBF) at rest measured twice (99m)Tc-ECD SPECT 10 treatment-naïve SAD. In first session, subjects were given an...
Psychosis is a heterogeneous psychiatric condition for which multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength evidence associations between each factor psychotic disorders whilst controlling several biases. The Web Knowledge database was searched identify systematic reviews meta‐analyses observational studies examined socio‐demographic, parental, perinatal, later or antecedents disorders, included comparison group healthy...
Outcomes of psychotic disorders are associated with high personal, familiar, societal and clinical burden. There is thus an urgent need for improving those outcomes. Recent advances in research knowledge have opened new opportunities ameliorating outcomes psychosis during its early stages. This paper critically reviews these opportunities, summarizing the state‐of‐the‐art focusing on recent discoveries future avenues first episode interventions. Candidate targets primary universal prevention...
<h3>Context</h3> Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. <h3>Objective</h3> To investigate the 2 main psychoactive constituents of<i>Cannabis sativa</i>(Δ9-tetrahydrocannabinol [Δ9-THC] cannabidiol [CBD]) on regional brain function during emotional processing. <h3>Design</h3> Subjects were studied 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces...
To develop a reporting guideline for overviews of reviews healthcare interventions.Development the preferred items (PRIOR) statement.Core team (seven individuals) led day-to-day operations, and an expert advisory group (three provided methodological advice. A panel 100 experts (authors, editors, readers including members public or patients) was invited to participate in modified Delphi exercise. 11 panellists (chosen on basis expertise, representing relevant stakeholder groups) were take...
Peak-based meta-analyses of neuroimaging studies create, for each study, a brain map effect size or peak likelihood by convolving kernel with reported peak. A is small matrix applied in order that voxels surrounding the have value similar to, but slightly lower than Current kernels are isotropic, i.e., voxel close to only depends on Euclidean distance between and However, such perfect spheres around rather implausible: correlates across individuals more likely be part cluster significant...