A5101560559- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Dermatologic Treatments and Research
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- interferon and immune responses
- NF-κB Signaling Pathways
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Liver Disease and Transplantation
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Organ Transplantation Techniques and Outcomes
- Telomeres, Telomerase, and Senescence
- Semiconductor materials and devices
- Animal Virus Infections Studies
- PARP inhibition in cancer therapy
- Polymer composites and self-healing
- RNA Research and Splicing
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Advancements in Semiconductor Devices and Circuit Design
Shanghai Institute of Hematology
2023-2025
Renji Hospital
2023-2025
Shanghai Jiao Tong University
2018-2025
Tsinghua University
2021-2024
Jilin Agricultural University
2021-2024
State Key Laboratory of Molecular Oncology
2024
Ruijin Hospital
2022-2024
Institute of Immunology
2024
Shanghai Institute of Nutrition and Health
2019-2023
University of Chinese Academy of Sciences
2016-2023
CRISPR screening identifies RNA m 6 A modification as negative regulator of TLR signaling pathway for proper innate immune response.
Background. Current prognostic models for liver transplantation (LT) recipients are not applicable long-term survival prediction, especially pediatric living donor LT recipients. In this retrospective study, we aimed to develop and validate a predictive model recipients, the Survival Predictive Model After Pediatric Liver Transplantation (SPPLT) model. Methods. A total of 2964 from Renji Hospital were enrolled randomly assigned training validation cohort by ratio 1:1. Logistic analysis was...
Abstract Exploration of medicines for efficient and safe management metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), selective farnesoid X receptor agonist, has been reported to ameliorate injury inflammation in various diseases. However, its clinical application is mainly limited by poor solubility, low bioavailability, potential side effects. Herein hepatic‐targeted nanodrugs composed OCA cholesterol‐lowering atorvastatin (AHT) with an ideal...
MLKL, a key component downstream of RIPK3, is suggested to be terminal executor necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice. Given RIPK3 has also been implicated non-necroptotic pathways including apoptosis and inflammatory signaling, it remains unclear whether the Fadd(-/-) mice indeed caused by necropotosis. Here, we show genetic deletion Mlkl developmental defect Fadd-deficient Fadd(-/-)Mlkl(-/-) are...
Because of its rather low melt strength, polylactide (PLA) has yet to fulfill promise as advanced biobased and biodegradable foams replace fossil-based polymer foams. In this work, PLA vitrimers were prepared by two-step reactive processing from commercial thermoplastics, glycerol, diphenylmethane diisocyanate (MDI) using Zn(II)-catalyzed addition transesterification chemistry. The reaction glycerol occurs with zinc acetate the catalyst, chain scission will take place due alcoholysis chains...
// Xianjun Yu 1, 2, * , Qun Zhao Xixi Zhang 1 Haiwei Yongbo Liu Xiaoxia Wu Ming Li Xiaoming Jingxuan 2 Xuzhi Ruan and Haibing Key Laboratory of Nutrition Metabolism, Institute for Nutritional Sciences, Shanghai Institutes Biological Chinese Academy University 200031, China Inflammation Molecular Pharmacology, School Basic Medical Hubei Medicine, Shiyan 442000, These authors have contributed equally to this work Correspondence to: Yu, email: xjyu_hbmu@126.com Zhang, hbzhang@sibs.ac.cn...
Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a synthetic derivative of oleanolic acid, triterpene, with apoptosis-inducing activity in wide range cancer cells. Induction apoptosis by CDDO-Me associated the generation reactive oxygen species (ROS) and inhibition telomerase activity. In present study, we investigated role ROS CDDO-me. Treatment MiaPaCa-2 Panc-1 pancreatic cell lines induced production hydrogen peroxide superoxide anions inhibited Pretreatment cells...
RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood. Here, we generated Ripk3 mutant mice by altering kinase domain (Ripk3Δ/Δ mice), thus abolishing its activity. Ripk3Δ/Δ cells were resistant stimulation vitro, protected from necroptotic diseases. mutation rescued Fadd−/− embryos, died within...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed term based on modified criteria. Although nonalcoholic (NAFLD) has been well-documented as multisystem disease, research the correlation of MAFLD and extra-hepatic diseases limited. This study aimed to clarify association MAFLD, well NAFLD status with cognitive function.A total 5,662 participants 20-59 years age who underwent tests ultrasonography in Third National Health Nutrition Examination Survey were...
The work output of shape memory polymers during shifting is desired for practical application as actuators. Herein, a polyolefin elastomer (POE) and paraffin wax (PW) are co-cross-linked by dynamic boronic ester bonds to enhance the network elasticity stress transfer between two phases, endowing high force storage capacity prepared vitrimers. Depending on phase PW, one-way realized programming at low temperature (25 °C), owing which solid PW can promote locking POE chains in low-entropy...
Background: Liver transplantation (LT) is the most efficient treatment for pediatric patients with end-stage liver diseases, while bacterial infection leading reason post-transplant mortality. The present study to explore outcomes and risk factors of early (within 1 months) after LT. Methods: In this prospective cohort study, 1316 recipients [median (IQR) age: 9.1 (6.3–28.0) months; male: 48.0%; median follow-up time: 40.6 (29.1–51.4) months] who received LT from September 2018 April 2022...
Potent, trans-2-(pyridin-3-yl)cyclopropanecarboxamide-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using fragment-based screening and structure-based design techniques. Multiple crystal structures obtained initial fragment leads, this structural information was utilized to improve biochemical cell-based potency associated molecules. Many optimized compounds exhibited nanomolar antiproliferative activities against tumor lines in...
A novel n-type nanowire/nanosheet (NW/NS) vertical sandwich gate-all-around field-effect-transistor (nVSAFET) with self-aligned and replaced high-κ metal gates (HKMGs) is presented for the first time, aiming at a 3 nm technology node beyond. The nVSAFETs were fabricated by an integration flow of Si/SiGe epitaxy, quasi-atomic layer etching (qALE) SiGe selective to Si, formation SiGe/Si core/shell NS/NW structure, building nitride dummy gate, replacement gate. This fabrication method...
To establish a detailed step-by-step example for the topical development of generic products. Topical semisolids are complex products requiring extensive research bioequivalence by establishing Q1/Q2/Q3. The process establishes Q1/Q2 selection and Q3 evaluation innovator proposed formulation. product along with formulation has been evaluated physicochemical properties. Once structure is matched formulation, invitro release in-vitro permeation study have conducted to move forward study....
Xanthohumol (XN), a prenylated chalcone present in hops (Humulus lupus L.) and beer, exhibits anti-inflammatory, antioxidant antiproliferative activity, but has not been studied for effects on T cell-mediated immune responses. Here we demonstrate that XN profound immunosuppressive cell proliferation, development of IL-2 activated killer (LAK) cells, cytotoxic lymphocytes (CTLs), production Th1 cytokines (IL-2, IFN-gamma TNF-alpha). The suppression these responses by was at, least part, due...
In an extension of our previous studies showing potent antitumorigenic activity synthetic triterpenoids oleanolic acid against prostate cancer cell lines, we examined the efficacy 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic (CDDO) in preventing development and/or progression transgenic adenocarcinoma mouse (TRAMP) model. Data show that oral gavage with CDDO (10 μmol/kg) for 20 weeks resulted inhibition preneoplastic lesions dorsolateral and ventral to without toxicity. also inhibited...