A5100389598- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- Concrete and Cement Materials Research
- Pharmacological Effects of Natural Compounds
- RNA Research and Splicing
- Microbial Metabolic Engineering and Bioproduction
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Analytical Chemistry and Sensors
- Antibiotic Resistance in Bacteria
- Traditional and Medicinal Uses of Annonaceae
- Magnesium Oxide Properties and Applications
- Ginseng Biological Effects and Applications
- RNA Interference and Gene Delivery
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Medicinal Plant Pharmacodynamics Research
- Antibiotics Pharmacokinetics and Efficacy
Shandong University
2025
Chuzhou University
2024
Anhui Medical University
2024
Chinese PLA General Hospital
2020-2024
Shandong First Medical University
2024
Anhui University of Science and Technology
2023
Peking Union Medical College Hospital
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Ocean University of China
2023
Creative Commons
2023
Mobile colistin resistance (mcr) genes represent an emerging challenge. Here we describe a novel mcr gene, mcr-10, on IncFIA plasmid of Enterobacter roggenkampii clinical strain. mcr-10 has the highest nucleotide identity (79.69%) with mcr-9 and encodes MCR-10 82.93% amino acids identical to MCR-9. confers 4-fold increase in MIC (from 1 4 mg/L) when cloned into colistin-susceptible E. By screening GenBank, was found various Enterobacteriaceae species countries four continents, suggesting...
The aroma profile of Chinese roasted sesame-like flavor type liquor was investigated by means headspace solid phase microextraction–aroma extract dilution analysis (HS-SPME-AEDA). Sixty-three odor-active regions were detected HS-SPME-AEDA with (FD) factors >5, and 58 these further identified. Among them, ethyl hexanoate, 2-furfurylthiol, dimethyl trisulfide, 3-methylbutanal, butanoate, 2-methylbutanoate, pentanoate, 4-methylpentanoate appeared the highest FD factors. In particular, eight...
Abstract Esophageal squamous cell carcinoma (ESCC) is prevalent in some geographical regions of the world. ESCC development presents a multistep pathogenic process from inflammation to invasive cancer; however, what critical these processes and how they evolve largely unknown, obstructing early diagnosis effective treatment. Here, we create mouse model mimicking human construct single-cell developmental atlas. We identify set key transitional signatures associated with oncogenic evolution...
Abstract Objectives The aim of this study was to investigate the anti-tumor effect resveratrol (RSV) on glioblastoma (GBM) and its specific mechanism in improving inflammatory response tumor microenvironment. microenvironment GBM is highly neuroinflammatory, inducing immunosuppression. Therefore, ameliorating an important focus for research. Methods RSV demonstrated through vitro cellular assays, including CCK-8, EdU, PI staining, Transwell, wound healing assay, flow cytometry. Potential...
The expression of microRNA (miRNA) changes in many diseases plays an important role the diagnosis, treatment, and prognosis diseases. Spinal cord injury (SCI) is a serious disease central nervous system, accompanied by inflammation, cell apoptosis, neuronal necrosis, axonal rupture, demyelination, other pathological processes, resulting impaired sensory motor functions patients. Studies have shown that miRNA has changed after SCI, miRNAs participate pathophysiological process treatment SCI....
Abstract Background Pancreatic cancer’s poor prognosis is caused by distal metastasis, which associated with epigenetic changes. However, the role of 3D epigenome in pancreatic cancer biology, especially its remains unclear. Methods Here, we developed high-resolution epigenomic maps cells derived from normal epithelium, primary and metastatic situ Hi-C, ChIP-seq, ATAC-seq, RNA-seq to identify key genes involved metastasis Results We found that A/B compartments, contact domains, chromatin...
Highly sensitive and selective analysis of sweat at ultra-low sample volume remains a major challenge in the field biosensing. Manipulation small volumes liquid for efficient sampling is essential to address this challenge. A hybrid Janus membrane with dual-asymmetry integration wettability conductivity developed regulated micro-volume transport wearable Unlike uncontrollable diffusion conventional porous membrane, asymmetric leads unique unidirectional high breakthrough pressure (1737.66...
This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing in patients receiving continuous renal replacement therapy (CRRT). The goal was optimize clinical guide rational use practice. A total 1,939 bacterial strains were analyzed, collected between April 2019 December 2021 through China Bloodstream Pathogens Antimicrobial Resistance Virulence Surveillance Network...
Pancreatic cancer (PC) is a highly fatal and aggressive disease with its incidence mortality quite discouraging. It of great significance to construct an effective prognostic signature PC find the novel biomarker for optimization clinical decision-making. Due crucial role immunity in tumor development, model based on nine immune-related genes was constructed, which proved be The Cancer Genome Atlas (TCGA) training set, TCGA testing entire GSE78229 GSE62452 set. Furthermore, S100A2 (S100...
Potent, trans-2-(pyridin-3-yl)cyclopropanecarboxamide-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using fragment-based screening and structure-based design techniques. Multiple crystal structures obtained initial fragment leads, this structural information was utilized to improve biochemical cell-based potency associated molecules. Many optimized compounds exhibited nanomolar antiproliferative activities against tumor lines in...
Two novel strains of members the genus Enterobacter, WCHEs120002T and WCHEs120003T, were recovered from sputum two patients at a hospital in PR China 2017. The Gram-stain-negative, facultatively anaerobic, motile non-spore-forming. subjected to whole-genome sequencing. Phylogenetic analysis based on core genes type species family Enterobacteriaceae revealed that belonged Enterobacter but distinct any previously known genus. Both average nucleotide identity silico DNA-DNA hybridization values...
To evaluate the dosimetric characteristics of ZAP-X stereotactic radiosurgery (SRS) for single brain metastasis by comparing with two mature SRS platforms. Thirteen patients treated CyberKnife (CK) G4 were selected retrospectively. The prescription dose planning target volume (PTV) was 18–24 Gy 1–3 fractions. PTV ranged from 0.44 to 11.52 cc.Treatment plans thirteen replanned using plan system and Gamma Knife (GK) ICON same organs at risk (OARs) constraints. normalized 70% both CK, while it...
Spatholobi Caulis (SC), the vine stem of Spatholobus suberectus Dunn, is a widely used traditional Chinese medicine (TCM) for treatment blood stasis syndrome and related diseases. Xylem phloem are main structures SC color xylem in red brown or while with resin secretions reddish to dark brown. They alternately arranged plurality concentric eccentric rings. In order investigate distribution patterns metabolites SC, an analytical method based on UFLC-QTRAP-MS/MS was established simultaneous...
A novel Kosakonia strain WCHEs120001T was recovered from the wound secretion of a patient at West China Hospital, Chengdu, PR China, in 2017. The Gram-stain-negative, facultatively anaerobic, motile, and non-spore-forming. preliminary analysis based on 16S rRNA gene sequence revealed that this closely related to members genus Kosakonia. subjected whole genome sequencing. Phylogenetic core sequences type strains all Enterobacteriaceae species belonged but were distinct any previously known...
Abstract BACKGROUND AND IMPORTANCE The Zap-X system (Zap Surgical Systems Inc, San Carlos, California) is a radically new surgical robot designed for brain and head neck radiosurgery. It represents the first dedicated stereotactic radiosurgery platform in almost half century optimizing goals of safety, speed, accuracy. was used required Chinese National Medical Products Administration clinical study. In early January 2020, 2 patients were treated with prior to national COVID-19 lockdown....
Trimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation TMA liver. The generation influenced diet, mainly due rich TMAO diet. However, it still unclear that effects different proportion source macronutrients dietary pattern on production process TMAO. Here, determined after single oral choline chloride intraperitoneal injection TMA, respectively, mice fed with carbohydrates,...
Sortase A (SrtA) has long been recognized as an ideal drug target for therapeutic agents against Gram-positive pathogens. However, the SrtA of Streptococcus suis (Ss-SrtA), important zoonotic agent, not studied. In this study, enzymatic properties Ss-SrtA were investigated, and inhibition by natural products was evaluated. expressed purified. The purified recombinant had maximal activity at pH 6.0-7.5, 45°C, showed a Km 6.7 μM hydrolysis substrate abz-LPATG-dnp. Different from Staphylococcus...
The first total synthesis of four 2-deoxy-3,6-anhydro hexofuranoside derivatives, namely sauropunols (A-D), isolated from the traditional Chinese medicinal plant Sauropus rostratus was accomplished. Structures A and B were clearly elucidated reassigned. anti-inflammatory activities (A-D) as well synthetic intermediates evaluated, which is valuable for further structure-activity relationship (SAR) studies on this class natural products.
Spinal cord injury (SCI) is a serious neurological that currently extremely difficult to cure clinically. SCI involves numerous pathophysiological processes, and microRNAs (miRNAs) play an important role in these processes. Meanwhile, miRNAs have received lot of attention for their other diseases as well. Therefore, the detection disease-related study disease development, treatment, prognosis. With rapid development molecular biology, traditional methods miRNA can no longer meet needs...