A5100413103- Catalytic C–H Functionalization Methods
- Carbohydrate Chemistry and Synthesis
- Drug Transport and Resistance Mechanisms
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Inflammatory mediators and NSAID effects
- Crystallization and Solubility Studies
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Synthesis of Indole Derivatives
- Circular RNAs in diseases
- Food Quality and Safety Studies
- Bone Metabolism and Diseases
- Synthesis and Biological Activity
- Catalytic Alkyne Reactions
- Oxidative Organic Chemistry Reactions
- Tea Polyphenols and Effects
- Extracellular vesicles in disease
- Gastroesophageal reflux and treatments
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Glycosylation and Glycoproteins Research
- Bone health and treatments
- Hormonal Regulation and Hypertension
- Essential Oils and Antimicrobial Activity
Inner Mongolia Electric Power (China)
2025
Affiliated Hospital of North Sichuan Medical College
2024
Central China Normal University
2022-2024
Fudan University
2024
Chinese PLA General Hospital
2023-2024
Qilu Hospital of Shandong University
2023-2024
First Affiliated Hospital of Zhengzhou University
2024
Sun Yat-sen University
2024
Hong Kong Baptist University
2019-2023
Hubei University
2019-2023
Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear cytoplasmic proteins. Overexpression enzyme adds O-GlcNAc to target proteins, transferase (OGT), perturbs cytokinesis promotes polyploidy, but molecular targets OGT are important for its cell cycle functions unknown. Here, we identify 141 previously unknown sites proteins function in spindle assembly cytokinesis....
Iron homeostasis plays a positive role in articular cartilage health. Excessive iron or overload can induce oxidative stress damage chondrocytes and ferroptosis cell death, advancing knee osteoarthritis (KOA). However, up to date, few effective agents treat overload-induced KOA (IOKOA). Chinese herbal medicine (CHM) provides abundant resources for drug selection manage bone metabolic conditions, including osteoporosis. Biochanin A (BCA) is novel bioactive multifunctional natural compound...
Abstract Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative disorders and imposes places heavy medical economic burdens on individuals society. Mechanical overloading applied to intervertebral (IVD) has been widely recognized as an important cause IVDD. overloading-induced chondrocyte ferroptosis was reported, but potential association between mechanical remains be illustrated in nucleus pulposus (NP) cells. In this study, we discovered that excessive...
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder with cognitive deficits, which becoming markedly more common in the world. Currently, exact cause of AD still unclear, and no curative therapy available for preventing or mitigating progression. Caffeic acid phenethyl ester (CAPE), a natural phenolic compound derived from honeybee hive propolis, has been reported as potential therapeutic agent against AD, while its application limited due to low water solubility poor...
Neutrophil extracellular traps (NETs) have been considered a significant unfavorable factor for wound healing in diabetes, but the mechanisms remain unclear. The therapeutic application of small vesicles (sEVs) derived from mesenchymal stem cells (MSCs) has received considerable attention their properties. Hypoxic preconditioning is reported to enhance potential MSC-derived sEVs regenerative medicine. Therefore, aim this study illustrate detailed mechanism NETs impairment diabetic and...
Abstract Chronic wounds are a major complication in patients with diabetes. Here, we identify therapeutic circRNA and load it into small extracellular vesicles (sEVs) to treat diabetic preclinical models. We show that circCDK13 can stimulate the proliferation migration of human dermal fibroblasts epidermal keratinocytes by interacting insulin-like growth factor 2 mRNA binding protein 3 an N6-Methyladenosine-dependent manner enhance CD44 c-MYC expression. engineered sEVs overexpress local...
With the rapid development of power market and large-scale integration renewable energy, load adjustment capacity system has become increasingly important. Large industrial users, as main component system, have significant potential. This paper proposes a adjustable potential assessment method for large users based on decadal time scale. By analyzing various indicators within decade, TOPSIS is used to comprehensively evaluate users. First, collect historical data related environmental users;...
Highlights•A systems pharmacology approach uncovers wogonoside as a TNBC angiogenesis inhibitor•Network analysis identifies that inhibits VEGF expression in TNBC•Wogonoside the Gli1 nuclear translocation and transcription activities•Wogonoside promotes Smoothened (SMO) degradation proteasome-dependent mechanismSummaryTriple-negative breast cancer (TNBC) is an aggressive heterogeneous disease lacks clinically actionable genetic alterations limit targeted therapies. Here we explore integrates...
Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder of gastro-intestinal tract, lacking effective drug targets and medications. Caffeic acid phenethyl ester (CAPE), phenolic constituent derived from propolis, has been reported to be potential therapeutic agent for IBD with low water solubility poor bioavailability. In this study, we synthesized new CAPE derivative (FA-97) aimed investigate the effect FA-97 on DSS-induced colitis. Here, found that attenuated body...
Distinct regio- and enantioselectivity control in copper-catalyzed vinylogous bisvinylogous propargylic substitution has been accomplished by using a novel chiral N,N,P ligand. The developed method provides an efficient selective approach to array of highly enantioenriched alkynyl unsaturated carbonyl compounds. Salient features include excellent functional group tolerance broad substrate scope. synthetic utility the is further demonstrated gram-scale synthesis application range...
To explore the impact of harvest season in white tea, high-performance liquid chromatography (HPLC) and amino acid analyzer were developed for determinations 17 phenolic compounds, 3 purine alkaloids, 19 acids, γ-aminobutyric (GABA) 4 main quality components 18 Bai mudan sub-type Xinyang teas harvested spring, summer autumn seasons, respectively. Additionally, vitro antioxidant capacity was evaluated by 5 various assays. Principal component analysis (PCA), hierarchical cluster (HCA) partial...
The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature steric hindrance at ortho-aryl substituents. Although various catalytic asymmetric methods have been developed for accessing axially chiral arylpyrroles, synthesis arylpyrroles 1,2-diaxes in manner has remained rare. Herein, authors report diverse and C-C C-N axes through copper-catalysed asymmetirc [4 + 1] annulation yne-allylic esters...
The Heck reaction between arenes and allyl acetate has led to cinnamyl derivatives products depending on the regioselectivity of β-elimination. can be controlled by solvent in Rh(III)-catalyzed arene–allyl coupling via C–H activation: (1) THF, β-H elimination were generated; (2) MeOH, β-OAc produced. Both routes have advantages such as excellent γ-selectivity toward acetate, good yields, broad substrate scope.
Green, white and black teas showed different degrees in enzymatic fermentation through relevant processing procedures. To reveal the impact of tea-leaves, 44 chemical components including 17 phenolic compounds, 3 purine alkaloids, 19 free amino acids γ-aminobutyric acid (GABA) 27 various tea samples were determined by HPLC analyzer, respectively. Additionally, E-tongue 5 assays developed for taste evaluation vitro antioxidant activities analysis. Multivariate statistical analyses, such as...
The producing area of Chinese white tea has been expanded to Xinyang and Yunnan from Fuding region. In this study, six sensory tastes fifty-one chemical components including seventeen phenolic compounds, three purine alkaloids twenty amino acids were determined in eighteen Bai mudan sub-type by electronic tongue, high performance liquid chromatography acid analyzer for geographical identification, respectively. Additionally, vitro antioxidant activities evaluated five various assays....
An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive<italic>trans</italic>1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions.
This article reviews the bioinspired design and characterization techniques of different types micro/nanomotors their biomedical applications in cancer diagnosis treatment.
Flavanols are privileged heterocyclic compounds in medicinal chemistry. It is notable to develop an efficient and straightforward protocol for accessing chiral flavanols with precise control of the stereocenters. Here, a highly kinetic resolution chromenes was reported via Cu-catalyzed asymmetric hydroboration. This previously unidentified approach features one-step synthesis flavan-3-ols containing two vicinal stereogenic centers (s factor up 1060, >99% ee most products). In addition,...
Organ transplantation is a critical treatment for end-stage organ failure, but long-term graft survival remains suboptimal due to ischemia-reperfusion injury (IRI) and transplant rejection. The immune microenvironment, especially macrophages, plays key role in these processes. Various forms of regulated cell death (apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis) macrophages significantly influence rejection by mediating cellular communication shaping the microenvironment....
An ynamide-mediated one-pot, two-step intermolecular esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species was reported. A broad substrate scope respect to acids, alcohols, and phenols observed. The α-acyloxyenamide intermediates formed by addition ynamides proved be effective acylating reagents for alcohol phenol derivatives assistance base catalysis. Notably, racemization α-chiral center can avoided.
Abstract Background As a novel necrosis manner, ferroptosis has been increasingly reported to play role in tumor progression and treatment, however, the specific mechanisms underlying its development prostate cancer remain unclear. Growing evidence showed that peroxisome plays key ferroptosis. Herein, we identified mechanism for involvement of progression, which may provide new strategy clinical treatment cancer. Methods Label-Free Mass spectrometry was used screen identify candidate...