A5012148489- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Extracellular vesicles in disease
- Diabetic Foot Ulcer Assessment and Management
- Laser Applications in Dentistry and Medicine
- Advancements in Transdermal Drug Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Optical Coherence Tomography Applications
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
Chinese PLA General Hospital
2023-2025
Tianjin Medical University
2023-2025
Abstract Delayed wound healing is a major complication of diabetes, and associated with impaired cellular functions. Current treatments are unsatisfactory. Based on the previous reports microRNA expression in small extracellular vesicles (sEVs), miR‐17‐5p‐engineered sEVs (sEVs 17‐OE ) encapsulated them gelatin methacryloyl (GelMA) hydrogel for diabetic wounds treatment fabricated. SEVs successfully fabricated 16‐fold increase miR‐17‐5p expression. inhibited senescence promoted proliferation,...
Neutrophil extracellular traps (NETs) have been considered a significant unfavorable factor for wound healing in diabetes, but the mechanisms remain unclear. The therapeutic application of small vesicles (sEVs) derived from mesenchymal stem cells (MSCs) has received considerable attention their properties. Hypoxic preconditioning is reported to enhance potential MSC-derived sEVs regenerative medicine. Therefore, aim this study illustrate detailed mechanism NETs impairment diabetic and...
Abstract Hypertrophic scar (HS) is a common fibroproliferative disease caused by abnormal wound healing after deep skin injury. However, the existing approaches have unsatisfactory therapeutic effects, which promote exploration of newer and more effective strategies. MiRNA‐modified functional exosomes delivered dissolvable microneedle arrays (DMNAs) are expected to provide new hope for HS treatment. In this study, miRNA, miR‐141‐3p, downregulated in tissues hypertrophic fibroblasts (HSFs),...
Abstract Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential therapeutic strategies targeting ferroptosis. Secretory autophagosomes (SAPs) carrying cytoplasmic cargoes have been recognized as novel nano‐warrior to defeat diseases. Here, it is hypothesized that SAPs derived from human umbilical vein endothelial cells (HUVECs) can restore function skin repair by inhibiting ferroptosis promote diabetic wound healing. High glucose...
Scar Treatment In article number 2305374, Haihong Li, Xiaobing Fu, Cuiping Zhang, and co-workers reported a simple effective approach to prepare dissolving microneedle arrays containing miR-141-3pOE-Exos for hypertrophic scar treatment. The miR-141OE-Exos@DMNAs exhibited the ability control sustained release of decrease thickness.
ABSTRACT Delayed diabetic wound healing is partially attributed to the functional disorder of skin repair cells caused by high glucose (HG). Small extracellular vehicles (sEVs) loaded with small‐molecule drugs represent a highly promising therapeutic strategy. This study aims evaluate efficacy ellagic acid‐encapsulated small vesicles (EA‐sEVs) in regeneration and unravel related mechanisms. Cytotoxicity tests acid (EA) as liposomal molecules (LSMs) were performed CCK8 assay. EA was...