A5115028402- Extracellular vesicles in disease
- Childhood Cancer Survivors' Quality of Life
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Signaling Pathways in Disease
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Hangzhou Medical College
2025
Zhejiang Provincial People's Hospital
2025
Affiliated Hospital of North Sichuan Medical College
2024
Children's Hospital of Zhejiang University
2015
Parkinson's disease (PD) is a common neurodegenerative and difficult to treat due its elusive mechanisms. Recent studies have identified striking association between oligodendrocytes PD progression, yet how regulate the pathogenesis of still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) upregulated in substantia nigra prosaposin (PSAP) secretion increased parkinsonian mice. The released PSAP can induce interleukin (IL)-6 upregulation from via GPR37-dependent pathway,...
The pre-diagnosis plasma proteomic contexture of colon cancer patients may reflect host immune and biological conditions potentially associate with survival outcomes. We aimed to characterize contextures in determine potential association overall the patients. Baseline samples collected at an average 7.90 years before diagnosis from UK Biobank cohort were analyzed using Olink proteomics technology. Cox-regression analysis was applied identify distinct their In early-stage cancer, a...
ABSTRACT Background Previous studies have implicated the involvement of FAM3C in cancerous development and progression. Herein, we aimed to further investigate oncological mechanism FAM3C, specifically glioma. Methods We utilized open‐source bioinformatics tools platforms analyze transcriptional expression levels, prognosis, correlation with clinical variables gliomas, subsequently, hypothesize its potential molecular functions possibly associated signaling pathways. Following this, glioma...
The prognostic value of the Musashi-2 (MSI2) gene has not yet been studied in childhood acute lymphoblastic leukemia (ALL). In our study, MSI2 mRNA levels 119 patients with newly-diagnosed ALL were examined and analyzed regard to clinical characteristics outcomes. demonstrated significantly higher than healthy controls. addition, correlated disease status IK6 mutation status. Survival analyses showed that predicted worse outcomes ALL. Moreover, multivariate analyses, overexpression retained...