A5101986978- Air Quality and Health Impacts
- Physics of Superconductivity and Magnetism
- Orthopedic Surgery and Rehabilitation
- Advanced Condensed Matter Physics
- Bone fractures and treatments
- Climate Change and Health Impacts
- Hip and Femur Fractures
- Corneal surgery and disorders
- Energy and Environment Impacts
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Crystallization and Solubility Studies
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- Aquatic Ecosystems and Phytoplankton Dynamics
- Ophthalmology and Visual Impairment Studies
- X-ray Diffraction in Crystallography
- Reconstructive Surgery and Microvascular Techniques
- Ferroptosis and cancer prognosis
- Quantum and electron transport phenomena
- Quantum many-body systems
- Magnetic and transport properties of perovskites and related materials
- Colorectal Cancer Surgical Treatments
- Total Knee Arthroplasty Outcomes
- Tryptophan and brain disorders
Chinese Academy of Sciences
1993-2025
Zhejiang University
1989-2025
Sir Run Run Shaw Hospital
2022-2025
Institute of Atmospheric Physics
2021-2025
Fuzhou Maternity and Child Health Care Hospital
2023-2025
Nanjing Normal University
2025
Central South University
2024
Guangzhou University of Chinese Medicine
2023
Fujian Medical University
2018-2023
Huadong Hospital
2003-2023
Gut microbes play significant roles in colitis development. The current study was aimed to uncover the preventive effects of lycopene (LYC), a functional carotenoid component, on and accompanied behavior disorders. demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented dextran sulfate sodium (DSS)-induced gut barrier damages inflammatory responses male mice. improved DSS-induced depression anxiety-like behavioral disorders by suppressing neuroinflammation synaptic...
Parkinson's disease (PD) is a common neurodegenerative and difficult to treat due its elusive mechanisms. Recent studies have identified striking association between oligodendrocytes PD progression, yet how regulate the pathogenesis of still unknown. Here, we show that G-protein-coupled receptor 37 (GPR37) upregulated in substantia nigra prosaposin (PSAP) secretion increased parkinsonian mice. The released PSAP can induce interleukin (IL)-6 upregulation from via GPR37-dependent pathway,...
Immunotherapy has emerged as a significant strategy to treat numerous tumors. The positive response immunotherapy depends on the dynamic interaction between tumor cells and infiltrating lymphocytes in microenvironment (TME). Pyroptosis, inflammation-induced cell death, is intricately associated with several However, relationship pyroptosis clinical prognosis, immune infiltration, effect unclear breast cancer (BRCA).We comprehensively evaluated 33 pyroptosis-related genes systematically...
Abstract Background The impact of sarcopenia on the outcome patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, present study was performed to evaluate effect cancer. Methods Patients pathologically diagnosed stage I, II III or who had undergone curative surgery between January 2008 December 2014 were retrospectively reviewed. psoas muscle index (PMI) identified by 3D-image analysis computed tomographic images criterion used diagnose sarcopenia....
Most existing epidemiological studies on the impact of air pollution noncommunicable diseases have focused urban areas, rather than nationwide that include rural areas. This study utilized a time-stratified case-crossover included deaths registered in National Mortality Surveillance System from 2008 to 2020. Atmospheric particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), sulfur (SO2), carbon monoxide (CO) were evaluated via Nested Air Quality Prediction Modeling System. Conditional...
Flap necrosis is a critical complication following modified radical mastectomy (MRM) for breast cancer (BC). It not only impairs wound healing but also delays postoperative treatment, adversely affecting patient survival rate and the overall quality of life. Thus, developing an accurate prediction model crucial early intervention improving prognosis. To develop validate Nomogram based on Logistic regression to assess risk flap in BC patients undergoing MRM. A retrospective study was...
The effects of Bone morphogenetic protein 2 (BMP-2) on the angiogenesis hepatocellular carcinoma have not yet been observed and its molecular mechanisms is clear. We first constructed recombinant lentivirus vectors expressing small hairpin RNA against BMP-2 gene (LV-SH-BMP2) over-expressing (overexpression-LV-BMP2), then two were respectively transfected into Hep G2 cells. cells with LV-SH-BMP2 or overexpression-LV-BMP2 co-cultured human umbilical vein endothelial (HUVECs) to observe HUVECs....
Objective To investigate the synergistic effects of cryptotanshinone (CPT) and doxorubicin (DOXO) on induction apoptosis in human gastric cancer cells mechanisms. Methods Cell proliferation were detected using CCK8 assay AnnexinV/PI staining, respectively. Western blotting was used to determine levels phosphorylation proteins encoded by STAT3-regulated genes cleaved forms caspases PARP. Results CPT significantly potentiated antiproliferative effect DOXO cell lines. combined with induced...
Osteoarthritis (OA) is a chronic degenerative disease wherein the articular cartilage exhibits inflammation and degradation. Scutellarin (SCU) flavonoid glycoside with range of pharmacological activities, as shown in previous studies demonstrating its anti-inflammatory activity. How SCU impacts progression OA, however, has not been explored to date. Herein, we assessed impact on murine chondrocytes an OA model system. In vitro assays, measured chondrocyte expression key OA-associated factors...
Background Breast cancer (BC) is one of the most common malignancies in women, and long non-coding RNAs (lncRNAs) are key regulators its development. T cells can recognize kill cells, CD4 + conventional (Tconv) main orchestrators immune function. However, research on Tconv-related lncRNAs (CD4TLAs) prognostic signature patients with BC still lacking. Method A TCGA database a GEO were used to collect patients. Through LASSO Cox regression analysis CD4TLAs-related models further constructed,...
Non-small cell lung cancer (NSCLC), which accounts for 85% of cases, calls better therapy. Yi-Fei-San-Jie-pill (YFSJ), a well-applicated traditional Chinese medicine formula, was reported to be effective in the treatment NSCLC. However, its anti-tumor mechanism still needs fully elucidated. Herein, reliable preclinical orthotopic but not subcutaneous model NSCLC mice established evaluate anti-cancer properties and further validate mechanisms YFSJ. A bioinformatic analysis executed identify...