A5101781767- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Glutathione Transferases and Polymorphisms
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Forensic Toxicology and Drug Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Angiogenesis and VEGF in Cancer
- Autoimmune Bullous Skin Diseases
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Quinazolinone synthesis and applications
- Retinal and Macular Surgery
- S100 Proteins and Annexins
- Nuclear Structure and Function
AdventHealth Orlando
2023-2025
Capital Medical University
2016-2024
Beijing Chest Hospital
2011-2024
Weifang Maternity and Child Care Hospital
2021-2022
Southwest Forestry University
2022
Shandong University of Traditional Chinese Medicine
2021
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021
Huazhong University of Science and Technology
2019
Baogang Group (China)
2019
Sichuan University
2015-2018
Significance Chronic obstructive pulmonary disease affects 10% of the worldwide population, and leading genetic cause is a disease, α-1 antitrypsin (AAT) deficiency. Humans have only one gene that codes for AAT protein, but mice up to six, which made it impossible decades create mouse model disease. Here we succeeded in creating this using CRISPR technology target all genes at once. Importantly, spontaneously develops lung recapitulates many aspects human We anticipate will be highly...
Sustained angiogenesis and increased PD-L1 expression on endothelial carcinoma cells contribute toward fostering an immunosuppressive microenvironment suitable for tumor growth. PD-L1+ CTCs were reported to associate with poor prognosis in NSCLC patients. However, whether or not aneuploid circulating (CTECs) express PD-L1, then serve as a surrogate biomarker evaluate immunotherapy efficacy remains unknown. In this study, novel SE-iFISH strategy was established comprehensively quantify...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) secreted by tumors was reported as a deleterious factor that led to the reduction of lymphocyte infiltration and poorer efficacy ICIs
M-type phospholipase A2 receptor (PLA2R) is known as a major antigen on podocytes, which involved with the pathogenesis of idiopathic membranous nephropathy (iMN). Many studies have shown that serum anti-PLA2R autoantibodies (sPLA2R) are prevalent in patients iMN but rarely detected secondary (SMN) or other glomerulonephritis. The considered promising biomarker reports about its diagnostic value variable and inconsistent.To evaluate test accuracy (DTA) glomerular PLA2R (gPLA2R) for...
Lung cancer is the leading cause of cancer-related deaths. Survival rate improves significantly with early detection lung cancer. Effective methods can reduce mortality to a large extent as well benefit whole public health. The diagnostic value one single marker relatively low. Combined autoantibodies (AABs) improve sensitivity rather than rely on AAB and serve good reservoir for cancer.We designed three parts in our experiment. In training set we measured expression levels AABs 100...
The Warburg effect, also referred to as aerobic glycolysis, describes the dysregulated energy metabolism in cancer cells with rewired generation, which is hallmark of metabolic shift cancer. It a sign "acute cancer" and correlated high malignancy burden potential aggressive leukemia transformation lymphoma. We present case T-cell lymphoma that developed into life-threatening clinical syndrome driven by effect manifesting severe type B lactic acidosis refractory hypoglycemia. A 39-year-old...
Establishing the diagnosis of miliary tuberculosis (TB) can be challenging due to heterogeneous clinical presentations and low sensitivity diagnostic tests. Miliary TB shares overlapping clinical, radiological, histopathological features with other chronic granulomatous diseases, such as sarcoidosis, often posing a significant challenge for clinicians. A 36-year-old male from Haiti presented four-month history recurrent fever, dry cough, night sweats, weight loss. Chest imaging revealed...
Objective The purpose of this study is to understand the antimicrobial susceptibility and molecular distribution characteristics carbapenem-resistant Klebsiella pneumoniae (CRKP) in region, evaluate their correlation. Additionally, aims investigate transmission status these strains. Methods A total 150 CRKP collected from January 2019 December 2021 Ningbo region were included study. Antimicrobial testing was performed using broth microdilution method following CLSI guidelines (CLSI, 2023)....
Accumulating evidence has indicated that dysregulated microRNAs (miRNAs) are involved in cancer progression. In this study, we evaluated the clinicopathologic significance of miR-183-3p and miR-182-5p, role non-small-cell lung (NSCLC) progression.Seventy-six NSCLC patients from Beijing Chest Hospital were included. The expression miR-182-5p was by real-time quantitative polymerase chain reaction (RT-qPCR). Then, cell growth curve assays colony formation performed. Bioinformatics analysis...
Background Hyaluronan (HA) is one of the essential elements extracellular matrix (ECM), involved in onset metastasis various tumors. The interaction and binding ligand–receptor HA/cluster differentiation-44 (CD44) regulate physical biochemical properties ECM, which correlates with an increased propensity toward poor survival outcome. Our study aimed to explore HA for predicting rate patients small-cell lung cancer (SCLC). Materials Methods This prospective cohort recruited 72 SCLC. Plasma...
Aim: VEGF/VEGFR inhibitors may help immune checkpoint expand the population that will benefit from treatment. The authors investigated efficacy of combined bevacizumab and PD-1 antibody. Materials & methods: C57BL/6J mice were injected subcutaneously with 1 × 106 Lewis lung carcinoma cells. intraperitoneally 0.25 mg anti-PD-1 and/or 15 mg/kg bevacizumab. Tumor tissues harvested. reported a non-small cell cancer patient received 200 antibody 7.5 as fourth-line Results: Bevacizumab induced...
The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is associated with malignancy, and its molecular mechanisms in human lung cancer tumor malignancy. used RNA interference (RNAi) methodology celecoxib, a COX-2 inhibitor, effect knockdown on proliferation invasion abilities cells involved. Human adenocarcinoma A549-si10 LTEP-A2 transfected specific small interfering (A549-si10 LTEP-A2-si10, respectively) grew more slowly compared parental cell lines pU6....
Many studies have shown evidence that erythropoiesis-stimulating agents (ESAs), as a classic treatment for chronic kidney disease (CKD)-related anemia, several disadvantages and may trigger various adverse events with long-term use. The hypoxia-induced factor (HIF) pathway has been intensively investigated in disease, especially CKD, research HIF-mediated erythropoiesis might work potential therapeutic strategy managing CKD-related anemia. Development of prolyl hydroxylase domain inhibitors...
Patient-derived tumor xenografts (PDX) are considered as a more reliable experiment model for screening chemotherapeutic drugs. However, the tumorigenic rate differs depending on mouse strains, which generates experimental variability.In this study, we built PDX models of human non-small-cell lung cancer (NSCLC) in NOD/SCID mice comparison with BALB/c mice.The result showed that tumorigenesis (46.2%, 18/39) was higher than (17.39%, 4/23). Latent times (41±18 days) were shorter these (53±17...
Remarkably, the anti-cancer efficacy of immunotherapy in lung adenocarcinoma (LUAD) has been demonstrated. However, predicting beneficiaries this expensive treatment is still a challenge.A group patients (N = 250) diagnosed with LUAD and receiving were retrospectively studied. They randomly divided into training dataset (80%) test (20%). The was utilized to train neural network models predict patients' objective response rate (ORR), disease control (DCR), responders (progression-free...
As a transcription factor, p53 must accumulate in the nucleus to be effective. Signals related nuclear localization are distributed mainly C-terminal of p53. So these location domains were reserved and other part was removed this study. We investigated whether truncated (p53(DEL)) may affect proliferation invasive potential human lung cancer cells. H1299 801D cells expressing full-length p53(DEL) obtained by screening. Cell assay, cell apoptotic analysis, migration invasion assay performed....
Abstract Delta-like homolog 1 (DLK1) regulates noncanonical Notch signaling pathway as ligand. DLK1 was abnormally expressed in a variety of tumors, affecting tumorigenesis and developments. The biological function toward cell proliferation activation controversial across different types. Two currently known isoforms DLK1, which are membrane-tethered isoform soluble isoform, believed to be the key dual behaviors. While these not enough explain phenomena, our observations offer possibility...