A5048670134- Acute Ischemic Stroke Management
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Genomics and Rare Diseases
- Medical Imaging and Pathology Studies
- Thyroid and Parathyroid Surgery
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory Support and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Inflammation biomarkers and pathways
- Air Quality and Health Impacts
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Pharmacology and Obesity Treatment
- Chronic Lymphocytic Leukemia Research
- Cardiac Health and Mental Health
- Apelin-related biomedical research
Wenzhou Medical University
2017-2025
Minhang District Central Hospital
2018-2024
Fudan University
2018-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Zhejiang Taizhou Hospital
2017-2020
Taizhou Central Hospital
2019
Yunnan Population and Family Planning Research Institute
2015
Changhai Hospital
2011
Second Military Medical University
2011
Abstract Background Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed death ligand 1 (PD-L1) promoted progression drug resistance, facilitated tumor immune evasion. However, the detailed molecular mechanisms are still largely unknown. In present study, we aimed to explore role of circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis in regulation NSCLC progression, resistance microenvironment. Methods Real-Time qPCR Western Blot analysis were conducted...
Abstract Background Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) poorly comprehended. Methods The expression genes SCLC tissues and cells was measured by qRT-PCR. Colony formation, EdU, CCK-8, transwell wound healing well vivo assays revealed function SCLC. ChIP, luciferase reporter, RIP pull down demonstrated binding relation among genes. Results...
Circular RNAs (circRNAs) have emerged as regulators of cancer progression, including non-small cell lung (NSCLC). Tanreqing (TRQ), a traditional Chinese medicine, is used clinically for respiratory diseases. RT-qPCR quantified circ-WDR78 expression in NSCLC cells. Cell growth, apoptosis, invasion, and migration were assessed by functional assays. RNA-binding protein immunoprecipitation (RIP), luciferase reporter, RNA pull-down assays determined the competing endogenous (ceRNA) network...
Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in regulation NSCLC progression. In this study, we found that was high-expressed and miR-137 low-expressed tissues cells compared to their normal counterparts, which showed negative correlations tissues. Further experiments validated could be sponged inhibited by cells. addition, knock-down overexpression...
Circular RNAs (circRNAs) act as a crucial part in many human diseases, particularly cancers. circRNA HIPK3 (circHIPK3) is special that may participate the oncogenesis of non-small-cell lung cancer (NSCLC), even though its latent regulatory mechanism not very clear. Here, we studied roles circHIPK3 NSCLC. qRT-PCR assay was applied to study expression The influence on NSCLC estimated by silencing and miR-107 mock transfection brain-derived neurotrophic factor (BDNF) overexpression, correlation...
Abnormalities of forkhead box P3 (FOXP3) are implicated in various autoimmune diseases. This study is aimed at investigating the association ulcerative colitis (UC) with FOXP3 polymorphisms and its colonic expression Chinese patients. Polymorphisms rs3761548, rs2232365, rs2294021, rs3761547 were examined 472 UC patients 525 healthy controls using SNaPshot method. The mRNA protein was assayed inflammatory mucosa 34 normal 36 benign sigmoid polyps (normal controls) real-time quantitative...
OA is a multifactorial joint disease in which inflammation plays substantial role the destruction of joints. Corynoline (COR), component Corydalis bungeana Turcz., has anti-inflammatory effects.We evaluated significance and potential mechanisms COR development. The viabilities chondrocytic cells upon exposure were assessed by CCK-8 assays. Western blot, qPCR, ELISA used to assess extracellular matrix (ECM) degeneration inflammation. NF-κB pathway was western blot immunofluorescence (IF)....
Abnormal proliferation, apoptosis, migration and contraction of airway smooth muscle (ASM) cells in remodeling asthma are basically excessive repair responses to a network inflammatory mediators such as PDGF, but the mechanisms remain unclear. Nogo-B, member reticulum family 4(RTN4), is known play key role arteriogenesis tissue repair. Further studies needed elucidate Nogo-B abnormalities.A mouse model chronic was established by repeated OVA inhalation subjected expression analysis using...
Abstract Increasing evidence supports the involvement of periostin in pathophysiological processes stroke and atherosclerosis. The aim this study was to assess circulating levels at different times after large-artery atherosclerotic (LAA) their association with stroke. Serum were measured using enzyme-linked immunosorbent assay on day 1 162 patients LAA 108 age- sex-matched controls, 6 134 patients, during 4th week 46 patients. Stroke severity determined National Institutes Health Scale...
Abstract Background Biallelic mutations in the MYORG gene were first identified as cause of recessively inherited primary familial brain calcification. Interestingly, some heterozygous carriers also exhibited calcifications. Objectives To further investigate role single development Methods A nation‐wide cohort Chinese calcification probands was enrolled from March 2016 through September 2019. Mutational analysis performed 435 who negative for other four known calcification–causative genes (...
The incidence and mortality of lung cancer were extremely high. present study showed that SRCIN1 was an oncogene in non-small-cell (NSCLC). Public dataset analysis significantly overexpressed NSCLC samples. Also, we found patients with higher expression had shorter OS time by analyzing TCGA, Kaplan-Meier Plotter, GSE30219, GSE50081, GSE19188 databases. Overexpression or knockdown induced reduced A549 H1299 cell proliferation. Furthermore, directly targeted miR-211. miR-211 suppressed levels...
The Fc gamma receptor IIa (FcγRIIa), encoded by FCGR2A gene, has been suggested to play a crucial role in immunity linking immunoglobulin G antibody-mediated responses with cellular effector and regulatory functions. Polymorphisms have shown affect FcγRIIa/antibody interactions potentially implicated several autoimmune inflammatory conditions. This study was designed analyze the association between ulcerative colitis (UC) polymorphisms Chinese population.A total of 422 patients UC 710...
Summary Low testosterone is associated with late‐onset hypogonadism ( LOH ) and obesity. Recently, studies have shown that four single nucleotide polymorphisms SNP s), rs12150660, rs727428, rs5934505, rs10822184, are levels in populations of European descent. Therefore, we investigated whether the loci related to low testosterone, , or obesity a Chinese Han population. Ruling out co‐morbidities, DNA was prepared from 409 men (aged 40–65 years) serum (defined as total <11.6 nmol/L) 1 :...
In mammals, oleic acid (OA) induces pulmonary edema (PE), which can initiate acute lung injury (ALI) and lead to respiratory distress syndrome (ARDS). Pulmonary surfactant (PS) plays a key role in broad range of treatments for ARDS. The aim the present investigation was assess changes synthesis phosphatidylcholine (PC) from choline determine effect exogenous PS on its de novo rats with OA-induced PE. Experimental were randomized into three groups, including control group, PE group treated...
Aims The aryl hydrocarbon receptor (AhR) plays a pivotal role in regulating the innate and acquired immune systems. present study aimed to investigate association of Crohn's disease (CD) with AhR polymorphisms cohort patients from Southeast China. Methods An improved multiple ligase detection reaction technique was applied examine rs2158041, rs2066853, rs10249788 310 CD 573 controls. Results Compared controls, variant allele (T) genotype (CT+TT) rs2158041 were less frequent (both p < 0.05)....
This study aims to identify the risk factors associated with stroke-associated pneumonia (SAP) in patients who have undergone thrombectomy for acute ischemic stroke and develop a nomogram chart model predicting occurrence of pneumonia.
Abstract Background Ischemic stroke is a major global public health concern. This study evaluates the burden of ischemic in 2021, analyzes trends since 1990, and predicts future burdens. Methods Data were sourced from Global Burden Disease Study focusing on incidence, mortality, disability-adjusted life years (DALYs) global, regional, all socio-demographic index area (SDI) basis. Joinpoint regression age-period-cohort modeling employed for trend analysis. Results In there 7,804,449 (95% UI,...
<title>Abstract</title> Ischemic stroke is a significant global public health issue that impacts burdens across various regions. This study analyzed data from the Global Burden of Disease Study 2021 to assess incidence, mortality, and Disability-Adjusted Life Years (DALYs) associated with IS worldwide different Socio-Demographic Index (SDI) Using Joinpoint regression Age-Period-Cohort (APC) models, we examined trends in disease burden made projections for 2022 2035. As 2021, approximately...
<title>Abstract</title> Background The role that endovascular treatment (EVT) may play in stroke patients with large vessel occlusion (LVO) who are treated beyond 24 hours after onset is unclear. In this study, we aimed to examine the efficacy and safety of EVT based on uniform CT perfusion criteria appropriately selected patients. Methods A retrospective review was performed at a single center between January 2020 August 2023. We chose received via perfusion. matched group within 6–24 hour...