A5037193479- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- Ion Channels and Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune cells in cancer
- Respiratory Support and Mechanisms
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Ion channel regulation and function
- Pediatric health and respiratory diseases
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Herbal Medicine Research Studies
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Medicinal Plant Pharmacodynamics Research
- Cell death mechanisms and regulation
- Catalysis and Hydrodesulfurization Studies
- Tea Polyphenols and Effects
- Nanomaterials for catalytic reactions
- Genomics, phytochemicals, and oxidative stress
Nanjing University of Chinese Medicine
2017-2025
Fudan University
2019-2024
Zhongshan Hospital
2024
South China University of Technology
2023
Minhang District Central Hospital
2019-2022
Shenyang Jianzhu University
2017
Beijing University of Chinese Medicine
2015
Kunming Medical University
2009
Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism endothelial cells emerges as a promising option achieve vascular normalization antagonize progression. Herein, we demonstrated that salvianic acid A (SAA) played pivotal role in contributing tumor-bearing mice, thereby improving delivery effectiveness chemotherapeutic agent. SAA was capable inhibiting glycolysis strengthening junctions human umbilical vein (HUVECs) exposed...
Pyruvate kinase M2 (PKM2), playing a central role in regulating aerobic glycolysis, was considered as promising target for cancer therapy. However, its metastasis is rarely known. Here, we found tight relationship between PKM2 and breast metastasis, demonstrated by the findings that beta-elemene (β-elemene), an approved drug complementary therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated β-elemene inhibited cell migration, invasion vitro well...
Abstract Lung cancer has been proved to be one of the most common kinds cancers around globe. Meanwhile, as predominant type lung cancer, adenocarcinoma (LUAD) received increasing attention in research. Long noncoding RNAs (lncRNAs) are known associated with oncogenesis and progression various cancers. However, many lncRNAs have not thoroughly detected LUAD. In this study, through bioinformatics analysis we found that zinc finger protein multitype 2 antisense RNA 1 (ZFPM2‐AS1) was poor...
Intermetallic compounds have emerged as a class of promising electrocatalysts for fuel cells; however, it is still great challenge to synthesize monodisperse and small intermetallic phases by an economical scalable method. Herein, we demonstrate generally applicable solid-phase seed-mediated diffusion strategy controllable synthesis ordered L10-PtM (M = Mn, Fe, Co, Zn) nanoparticles, where the preprepared monodispersed Pt seeds are used growth sites. The freeze-drying procedure produces...
Mammalian target of rapamycin (mTOR) serves an important role in regulating various biological processes, including cell proliferation, metabolism, apoptosis and autophagy. Among these energy metabolism is the dominant process. The not only amino acids, fatty acids lipids, but also that nucleotides glucose has been indicated to be regulated by mTOR. Aerobic glycolysis, which a specific form prevalent carcinomas, it considered potential for cancer therapy. In reviewing complexity mTOR...
The association between capsaicin, the major natural pungent compound of chili peppers, and gastric cancer progression has engendered conflicting findings. In this work, we sought to explore character a high capsaicin diet in metastasis its possible mechanism. impact consumption on was investigated vivo (xenograft mouse zebrafish models) vitro (biochemical molecular assays). It demonstrated that gave rise accelerate tumor metastasis, which partially mediated by elevating expression transient...
// Xu Wang 1 , Suyun Yu Qi Jia Lichuan Chen Jinqiu Zhong Yanhong Pan Peiliang Shen Yin Siliang Zhonghong Wei Yuzhu Cao and Lu 1,2 Jiangsu Key Laboratory for Pharmacology Safety Evaluation of Chinese Materia Medica, School Pharmacy, Nanjing University Medicine, Nanjing, P. R. China 2 Collaborative Innovation Center Traditional Medicine Prevention Treatment Tumor, Correspondence to: Lu, email: Keywords : chronic kidney disease, traditional medicine, systems pharmacology, fibrosis, anemia,...
Aerobic glycolysis plays a decisive role in cancer growth. However, its metastasis was rarely understood. Cantharidin natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin possesses significant anti-metastatic activity on breast dependent inhibition of aerobic glycolysis. indicates migration and invasion cells, angiogenesis vitro, inhibits cells metastasizing to liver lung vivo. Subsequent results revealed that decreases the...
Biologically active natural products have been used for the chemoprevention of cutaneous tumors. Lycopene is main phytochemical in tomatoes. We herein aimed to assess cancer preventive effects lycopene and find potential molecular targets. In chemically-induced tumor mice cell models, attenuated incidence multiplicity as well tumorigenesis normal cells phase-selectivity (only promotion phase) manners. By utilizing a comprehensive approach combining bioinformatics with network pharmacology,...
Tumor cell extravasation across endothelial barrier has been recognized as a pivotal event in orchestrating metastasis formation. This is initiated by the interactions of extravasating tumor cells with (ECs). Therefore, targeting crosstalk between and ECs might be promising therapeutic strategy to prevent metastasis. In this study, we demonstrated that Rh1, one main ingredients ginseng, hindered invasion breast cancer (BC) well diminished permeability both vitro vivo, which was responsible...
Radiofrequencies have shown efficacy in addressing skin aging. Despite their effectiveness, few studies explored how radiofrequencies affect the transcriptome. This study utilized mouse models divided into two age groups (four-month-old and one-year-old mice) to assess impact of a radiofrequency device on collagen elastin. A combination histological analysis, Western blot real-time PCR transcriptome sequencing was employed. Histological analysis revealed significant increases dermis...
Context It is common sense that chewing a mint leaf can cause cooling feeling, while ginger root will produce burning feeling. In Traditional Chinese Medicine (TCM), this phenomenon referred to as 'cold/hot' properties of herbs. Herein, it reported TCM with different "cold/hot" have effects on the variation cells.Objective To explore intrinsic from perspective cellular and molecular biology.Materials methods A375 cells were selected using Cancer Cell Line Encyclopaedia (CCLE) analysis...
The abnormal expression of Transient Receptor Potential cation channel subfamily V member 4 (TRPV4) is closely related to the progression multiple tumors. In addition, TRPV4 increasingly being considered a potential target for cancer therapy, especially in tumor metastasis prevention. However, biological correlation between and metastasis, as well specific role malignant melanoma poorly understood. this study, we aimed examine through experiments clinical data analysis, underlying anticancer...