A5103004933- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Flavonoids in Medical Research
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Vibrio bacteria research studies
- Heme Oxygenase-1 and Carbon Monoxide
- Mycotoxins in Agriculture and Food
- Alkaloids: synthesis and pharmacology
- Sirtuins and Resveratrol in Medicine
- Neurological Disease Mechanisms and Treatments
- Berberine and alkaloids research
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- Fungal Biology and Applications
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
Hebei Agricultural University
2025
Hunan Agricultural University
2022-2024
Integrated Chinese Medicine (China)
2023-2024
Ministry of Education of the People's Republic of China
2023-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2013-2024
Guangdong Pharmaceutical University
2007-2024
Guiyang Medical University
2019-2024
Affiliated Hospital of Guizhou Medical University
2019-2024
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
This study aims to identify the inhibitory role of spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism action rats mice. First, GLP-1Rs were identified be specifically expressed on microglial cells dorsal horn, profoundly upregulated after peripheral nerve injury. In addition, intrathecal GLP-1R agonists GLP-1(7–36) exenatide potently alleviated formalin-, injury-, bone cancer-, diabetes-induced states by 60–90%, without affecting acute...
OBJECTIVE: To investigate the effects of exenatide on blood glucose, body weight and hepatic enzymes in patients with type 2 diabetes mellitus (T2DM) concomitant non-alcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS: One hundred seventeen T2DM NAFLD were randomly divided into group metformin group. Patients treated metformin, respectively, for 12 weeks. RESULTS: After weeks treatment, weight, mass index (BMI), waist-to-hip ratio, HbA1c, FPG, 2-h PPG, ALT, AST, γ-GT, hs-CRP...
Alzheimer’s disease (AD) is a complex degenerative of the central nervous system that clinically characterized by progressive decline in memory and cognitive function. The pathogenesis AD intricate not yet fully understood. Neuroinflammation, particularly microglial activation-mediated neuroinflammation, believed to play crucial role increasing risk, triggering onset, hastening progression AD. Modulating activation regulating energy metabolic disorder are seen as promising strategies...
Osteoarthritis (OA) is a degenerative joint disease, Increasingly, mitochondrial autophagy has been found to play an important regulatory role in the prevention and treatment of osteoarthritis. Koumine bioactive alkaloid extracted from plant Gelsemium elegans. In previous research, was have potential improving progression OA rats. However, specific mechanism its action not fully explained. Therefore, aim this study investigate whether can alleviate rats by influencing autophagy. vitro study,...
Objective Hypothyroidism (HO) can induce significant metabolic dysfunction and increase cardiovascular disease risk. In the present study, we investigated relationship between homocysteine (Hcy) insulin resistance (IR) in patients with HO or subclinical hypothyroidism (SHO). Methods A total of 270 subjects were enrolled. All divided into following three groups: HO, SHO control. Plasma levels Hcy measured, each patient's homeostatic index (HOMA-IR) was calculated. Statistical analyses carried...
Two peptide agonists of the glucagon-like peptide-1 (GLP-1) receptor, exenatide and GLP-1 itself, exert anti-hypersensitive effects in neuropathic, cancer diabetic pain. In this study, we have assessed anti-allodynic anti-hyperalgesic non-peptide agonist WB4-24 inflammatory nociception possible involvement microglial β-endorphin pro-inflammatory cytokines.We used rat models induced by formalin, carrageenan or complete Freund's adjuvant (CFA), to test mechanical allodynia thermal...
Lamiophlomis rotata is an orally available Tibetan herb prescribed for the management of pain, with shanzhiside methylester (SM) and 8-O-acetyl-SM as quality control ingredients. This study aimed to evaluate antinociceptive properties L. rotata, determine whether SM are principle effective ingredients, explore produces antinociception through activation spinal glucagon-like peptide-1 receptors (GLP-1Rs).Formalin test, neuropathic bone cancer pain models were used, animal sample size was 5 6...
Mammalian target of rapamycin (mTOR) serves an important role in regulating various biological processes, including cell proliferation, metabolism, apoptosis and autophagy. Among these energy metabolism is the dominant process. The not only amino acids, fatty acids lipids, but also that nucleotides glucose has been indicated to be regulated by mTOR. Aerobic glycolysis, which a specific form prevalent carcinomas, it considered potential for cancer therapy. In reviewing complexity mTOR...
Citrinin, a secondary metabolite, can pose serious risks to the environment and organisms, but its hepatotoxic mechanisms are still unclear. Histopathological ultrastructural results showed that citrinin-induced liver injury in Kunming mice, mechanism of hepatotoxicity was studied L02 cells. Firstly, citrinin mades cell cycle arrest G2/M phase by inhibition cyclin B1, D1, cyclin-dependent kinases 2 (CDK2), CDK4 expression. Secondly, inhibits proliferation promotes apoptosis cells via...
Resveratrol is well known for its anti-inflammation and anti-oxidant properties, has been shown to be effective in alleviating the development of obesity. The purpose this investigation was analyze effect resveratrol on renal damage obese rats induced by a high-fat diet (HFD) possible mechanisms. Male Sprague-Dawley were divided into three groups: control, HFD, HFD plus (treated with 100 mg/kg/day resveratrol). Body weight, serum urine metabolic parameters, kidney histology measured....
Deficits in glucose, impaired insulin signalling and brain resistance are common the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce amyloid pathology AD. Moreover, it is a well-known fact that curcumin has anti-oxidant anti-inflammatory properties. However, whether or not could regulate signal transduction pathway remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as model to...
Vibrio alginolyticus is a food-borne marine that causes gastroenteritis, otitis media, externa, and septicemia in humans. The pathogenic mechanisms of V. have previously been studied aquaculture animals; however, the underlying mammals remain unknown. In this study, an vitro model mouse peritoneal macrophages infected with was established. qPCR results revealed induced transcription levels various cytokines, including IL-1β, IL-12, IL-18, TNF-α, IL-17, IL-6, IFN-γ, IL-10, secretion level...
T-2 toxin, a mycotoxin found in foods and feeds, poses threat to female reproductive health both humans animals. LncRNA CUFF.253988.1 (CUFF.253988.1), highly expressed pigs, has an undisclosed regulatory role. This study aimed establish model of toxin-induced ovarian injury sows, vivo vitro, explore the role potential mechanisms CUFF.253988.1. The results showed that feeding toxin-contaminated feed (1 mg/kg) induced follicle atresia mitochondrial structural damage, accompanied by significant...
Root-applied low-concentration NaCl (e.g., 40 mM) has been shown to maintain the yield and enhance both nutritional functional quality in salt-sensitive strawberry cultivars. However, potential benefits of foliar application on plants have rarely investigated avoid secondary soil salinization through long-term root application, especially effects fruit during greenhouse high-temperature periods. Strawberry (Fragaria × ananassa Duch. cv. Benihoppe) were sprayed with 0 (CK), 5, 10, 15, 20 mM...