A5030930581- Protein Structure and Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Advanced Photocatalysis Techniques
- Axon Guidance and Neuronal Signaling
- RNA regulation and disease
- Polymer Nanocomposites and Properties
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Enzyme Structure and Function
- Cell death mechanisms and regulation
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
- Autophagy in Disease and Therapy
- Copper-based nanomaterials and applications
- Circular RNAs in diseases
- Thermal properties of materials
- Biochemical effects in animals
- Hippo pathway signaling and YAP/TAZ
- Melanoma and MAPK Pathways
- RNA modifications and cancer
- Ammonia Synthesis and Nitrogen Reduction
- Natural Fiber Reinforced Composites
- Advanced Cellulose Research Studies
- Zebrafish Biomedical Research Applications
Jilin University
2021-2025
Affiliated Hospital of Qingdao University
2018-2025
Qingdao University
2018-2025
Guilin University of Technology
2022-2025
Tianjin University
2022-2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2022-2025
Jilin Medical University
2024-2025
West China Hospital of Sichuan University
2020-2024
Sichuan University
2020-2024
Case Western Reserve University
2016-2023
Development of potent and broad-spectrum antimicrobial peptides (AMPs) could help overcome the resistance crisis. We develop a peptide language-based deep generative framework (deepAMP) for identifying potent, AMPs. Using deepAMP to reduce enhance membrane-disrupting abilities AMPs, we identify, synthesize, experimentally test 18 T1-AMP (Tier 1) 11 T2-AMP 2) candidates in two-round design by employing cross-optimization-validation. More than 90% designed AMPs show better inhibition...
Reactive oxygen species (ROS) generation and massive epithelial apoptosis are critical in the pathogenesis of intestinal ischemia/reperfusion (I/R) injury. We previously found that Sirtuin 1 (SIRT1)-mediated antioxidant pathway was impaired intestine after I/R. Here, we investigate potential role SIRT1-targeting microRNAs (miRNAs) regulating ROS accumulation I/R, important SIRT1 involved in.C57BL/6 mice were subjected to I/R induced by occlusion superior mesenteric artery followed...
Abstract The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, regulation HMGB1 NAFLD, particularly through sirtuin (SIRT1), remains unclear. In this study, we investigated SIRT1-mediated inhibition release NAFLD and effect salvianolic acid B (SalB), which is water-soluble phenolic extracted from Radix Salvia miltiorrhiza , on SIRT1/HMGB1 signaling. vivo SalB treatment significantly...
High-mobility group protein box 1 (HMGB1) is essential in the response to injury during sepsis. We hypothesized that resveratrol (RESV) administration would inhibit nuclear-cytoplasmic HMGB1 translocation hepatocytes, which associated with sirtuin (SIRT1) upregulation. investigated regulatory role of SIRT1 nucleocytoplasmic and its effect on sepsis-induced liver injury.Rats were randomly assigned pretreatment RESV (60 mg/kg per day), nicotinamide or vehicle (olive oil), was administered by...
Autophagy is an essential cytoprotective response against pathologic stresses that selectively degrades damaged cellular components. Impaired autophagy contributes to organ injury in multiple diseases, including ischemia/reperfusion (I/R), but the exact mechanism by which impaired regulated remains unclear. Several researchers have demonstrated microRNAs (miRNAs) negatively regulate targeting autophagy-related genes (ATGs). Therefore, effect of ATG-related miRNAs on I/R a promising research...
Abstract The applications of thermal interface material (TIM) based on boron nitride (BN)‐filled polymer composites are often constrained by weak interfacial interactions between BN and the matrix. In this work, hyperbranched (H‐Si69) was synthesized polycondensation surface using a sulfur‐containing coupling agent. agent modified (g‐BN), natural rubber (NR)/g‐BN were prepared with higher conductivity mechanical properties. (0.665 W/mK), tensile strength (19.78 MPa), elongation at break...
Carbenes are critical intermediates in organic chemistry, recognized for their exceptional reactivity and versatility. However, conventional methods carbene generation often associated with safety risks hazardous procedures. This study presents a Ga-ZnO1–x nanosheets photocatalyst (100) preferred orientation, featuring abundant refined frustrated Lewis pair (FLP) sites, excellent light absorption, efficient charge transport properties. Under visible irradiation, this catalyst activates...
Summary Objective Micro RNA s (mi s) are noncoding small that control gene expression at the posttranscriptional level. Some dysregulated mi have been shown to play important roles in epileptogenesis. The aim of this study was determine if miR‐199a‐5p regulates seizures and seizure damage by targeting antiapoptotic protein silent information regulator 1 ( SIRT 1). Methods Hippocampal levels miR‐199a‐5p, 1, acetylated p53 were quantified quantitative real‐time polymerase chain reaction...
Association of Raf kinase with activated Ras triggers downstream signaling cascades toward regulating transcription in the cells' nucleus. Dysregulation Ras-Raf stimulates cancers. We investigate C-Raf RBD and CRD regions when bound to oncogenic K-Ras4B at membrane. All-atom molecular dynamics simulations suggest that membrane plays an integral role configurational ensemble complex. Remarkably, complex samples a few states dynamically, reflecting competition between CRD- K-Ras4B-...
BACKGROUNDMicrobiota profiles differ between patients with pancreatic cancer and healthy people, understanding these differences may help in early detection of cancer.Saliva sampling is an easy cost-effective way to determine microbiota compared fecal tissue sample collection. AIMTo investigate the saliva microbiome distribution adenocarcinoma (PDAC) role oral risk prediction cancer. METHODSWe conducted a prospective study (n = 41) individuals 69).Bacterial taxa were identified by 16S...
Abstract Impairment in gut barrier function induced by intestinal ischemia/reperfusion (I/R) injury is associated with high morbidity and mortality. Intestinal requires the tight coordination of epithelial migration, proliferation differentiation. We previously observed that nuclear receptor-related protein 1 (nurr1)-mediated proliferative pathway was impaired I/R injury. Here, we aimed to assess effect nurr1 on evaluate microRNA (miRNA)-nurr1-mediated restoration an vivo mouse model...
Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is considered "holy grail" present-day cancer therapy, and recent discoveries small-molecule KRas4B inhibitors were made thanks to a deeper understanding structure dynamics this GTPase. Because interactions biological membranes are key for function, Ras-lipid have become major focus, especially because such evidently...
Significance Ras GTPases, KRas, HRas, and NRas control cell proliferation via the Ras/Raf/MEK/ERK pathway through a process in which dimerization is required but not mechanistically understood. Here, we show that Raf-RBD promotes resulting strong allosteric linkages between Galectin-binding residues on at two extreme ends of dimer. This suggests dimer Ras/Raf–RBD complex couples to Galectin dimers form multivalent signaling for synchronized activation Raf kinase, providing new framework be...
Understanding how cell-penetrating peptides translocate across cell membranes is of great importance in biomedicine. In this paper, we study the interactions between polyarginines and asymmetric by using coarse-grained molecular dynamics simulations. It found that a peptide has probability to penetrate through membrane because transmembrane potential difference; however, it difficult for single spontaneously while multiple can pore-mediated processes. Further, also provide insights into...
Intestinal epithelial oxidative stress and apoptosis constitute key pathogenic mechanisms underlying intestinal ischemia/reperfusion (I/R) injury. We previously reported that the adaptor 66 kDa isoform of molecule ShcA (p66Shc)-mediated pro-apoptotic pathway was activated after I/R. However, upstream regulators p66Shc involved in I/R remain to be fully identified. Here, we focused on role a prolyl-isomerase, peptidyl–prolyl cis–trans isomerase (Pin1), regulation activity during induced rats...