A5102941287- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Machine Learning in Bioinformatics
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Food composition and properties
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Polysaccharides Composition and Applications
- Mesenchymal stem cell research
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Enzyme Production and Characterization
- Probiotics and Fermented Foods
- Cholinesterase and Neurodegenerative Diseases
- Microbial Metabolites in Food Biotechnology
- Curcumin's Biomedical Applications
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Pyrroles
- Skin Diseases and Diabetes
Jiangnan University
2021-2023
State Key Laboratory of Food Science and Technology
2021-2023
Henan University
2019-2022
Henan Agricultural University
2019-2022
Second Affiliated Hospital of Guangzhou Medical University
2020-2022
Guangzhou Medical University
2020-2022
Ministry of Agriculture and Rural Affairs
2021
Nanjing Agricultural University
2019-2021
Zhejiang Hospital
2015-2021
University of Cincinnati
2018
The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-specific targets hinder the application chimeric antigen receptor (CAR) T cells in treatment solid tumours. Combining local with CAR cell immunotherapy may regulate TME enhance killing potency Here, we show that AXL, which is highly expressed non-small lung cancer (NSCLC) but not normal tissues, might be a target for therapy. AXL-CAR alone cause moderate regression subcutaneous pulmonary metastatic cell-derived...
Abstract Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused cell apoptosis, and research ferroptosis-inducing effect has rarely been reported. Herein, we first discovered excellent cytotoxicity towards human nasopharyngeal carcinoma cells elucidated its potential mechanisms. Morphology alterations mitochondrial ultrastructure, as observed via transmission...
Identification of essential proteins based on protein interaction network (PIN) is a very important and hot topic in the post genome era. Up to now, number network-based discovery methods have been proposed. Generally, static was constructed by using protein-protein interactions obtained from different experiments or databases. Unfortunately, most are sensitive reliability PIN. In this paper, we propose new method for constructing refined PIN gene expression profiles subcellular location...
Recent studies have shown the therapeutic potential of curcumin in Alzheimer's disease (AD). In 2014, our lab found that reduced Aβ40, Aβ42 and Aβ-derived diffusible ligands mouse hippocampus, improved learning memory. However, mechanisms underlying this biological effect are only partially known. There is considerable evidence brain metabolism indicating AD might be a brain-specific type diabetes with progressive impairment glucose utilisation insulin signalling. We hypothesised target both...
Deficits in glucose, impaired insulin signalling and brain resistance are common the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce amyloid pathology AD. Moreover, it is a well-known fact that curcumin has anti-oxidant anti-inflammatory properties. However, whether or not could regulate signal transduction pathway remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as model to...
Essential proteins are those necessary for the survival or reproduction of species and discovering such essential is fundamental understanding minimal requirements cellular life, which also meaningful to disease study drug design. With development high-throughput techniques, a large number Protein-Protein Interactions (PPIs) can be used identify at network level. Up now, though series network-based computational methods have been proposed, it still challenge improve prediction precision as...
A variety of bioactive spirobarbiturate-3-pyrrolidinones were prepared by a highly efficient domino aza-MIRC reaction barbiturate-derived alkenes with <italic>N</italic>-alkoxy α-haloamides under mild conditions.
Antimicrobial peptides (AMPs) play essential roles in maintaining intestinal health and have been suggested as possible therapeutic strategies against inflammatory bowel disease (IBD). However, the instability of AMPs process transmission vivo limits their application treatment IBD. In this study, we constructed mBD14-producing Lactococcus lactis NZ9000 (L. lactis/mBD14) to achieve enteric delivery mBD14 evaluated its protective effect on dextran sodium sulfate (DSS)-induced colitis. Mice...
The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and α-haloamides under mild conditions in good to excellent yields (up 99%). corresponding could be easily transformed into hydantoins via hydrolysis.
To observe the changes in Aβ40, Aβ42 and ADDLs brains of 3 month-old APPswe/PS1dE9 double transgenic mice after six-month intervention with curcumin, order to discuss neuroprotective effect curcumin.APPswe/PS1dE9dtg were randomly divided into model group, Rosiglitazone group (10 mg x kg(-1) d(-1)) curcumin high (400 kg9-1) d(-1)), medium (200 low (100 dosage groups, C57/BL6J same age background normal control group. After 6 months, immunohistochemical staining (IHC) Western blot method used...
Abstract A newly tertiary amine‐squaramide organocatalyst has been successfully developed and applied into the asymmetric Michael addition of 4‐hydroxycoumarin to β,γ‐unsaturated α‐ketoesters. The catalyst system performed well with a low loading 1 mol% under mild reaction conditions. series coumarin derivatives were obtained in good high yields (up 97%) enantioselectivities 96% ee ).
Abstract Chiral amine‐squaramide is a kind of effective hydrogen bond donor bifunctional catalyst to promote many asymmetric transformations. In this paper, novel chiral tertiary derived from the natural product stevioside was developed and applied into Michael addition acetylacetone nitroolefins. This reaction performed well, series enantiomerically enriched compounds were obtained in high yields (up 96%) with excellent enantioselectivities 99% ee).
Abstract A new tertiary amine-squaramide organocatalyst has been developed and applied to the asymmetric Michael addition of cyclic diketones β,γ-unsaturated α-keto esters. The catalyst system performed well with a low loading 1 mol% under mild reaction conditions. series synthetically pharmaceutically useful chiral bicyclic compounds were obtained in high yields (up 97%) excellent enantioselectivities 99 % ee). Furthermore, this catalytic can be used efficiently large-scale reactions being...