A5115590567- Congenital Heart Disease Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cardiac Valve Diseases and Treatments
- ATP Synthase and ATPases Research
- Metabolism, Diabetes, and Cancer
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- Energy and Environment Impacts
- Congenital Diaphragmatic Hernia Studies
- Selenium in Biological Systems
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Ionic liquids properties and applications
- Aortic Disease and Treatment Approaches
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Lignin and Wood Chemistry
- Viral Infections and Vectors
Ningxia Medical University
2014-2025
Christie's
2025
Novem (Netherlands)
2025
Shanghai Jiao Tong University
2024-2025
Shanghai Chest Hospital
2024-2025
Chengde Medical University
2024
Peking University
2011-2024
Hebei University of Science and Technology
2024
Southwest General Health Center
2024
Southwest Hospital
2018-2024
Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported that PKM2 also regulates apoptosis. However, mechanisms underlying such a remain elusive. Here we show translocates to mitochondria under oxidative stress. In mitochondria, interacts with phosphorylates Bcl2 at threonine (T) 69. This phosphorylation prevents binding Cul3-based E3 ligase subsequent degradation Bcl2. A chaperone protein,...
Abstract Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common complication diabetes. Recent researches have shown activation nuclear factor kappa light-chain enhancer activated B cells (NF- κ B) and NACHT, LRR PYD domain-containing protein 3 (NLRP3) inflammasome are associated with inflammation in progression DN, but exact mechanism unclear. Long noncoding RNAs (lncRNAs) roles development many diseases including DN. However, relationship between lncRNAs DN...
Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates cell cycle, but other substrates their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation results in c-Src-mediated phosphorylation at Y59, which interacts with nuclear pyruvate M2 (PKM2). PKM2 S37, promotes PKM2-dependent β-catenin transactivation c-Myc-upregulated expression glycolytic genes GLUT1,...
Immune microenvironment plays a critical role in lung cancer control versus progression and metastasis. In this investigation, we explored the effect of tumor-infiltrating lymphocyte subpopulations on biology by studying vitro cocultures, vivo mouse models, human tissue. Lymphocyte conditioned media (CM) induced epithelial-mesenchymal transition (EMT) migration both primary cells cell lines. Correspondingly, major accumulation Th9 Th17 was detected tissue correlated with poor survival....
6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD commonly upregulated and plays important roles many human cancers, while mechanism underlying such of remains elusive. Here we show upon EGFR activation, phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enhances activity increasing its binding affinity to therefore activates PPP...
IL-17-producing CD8+ (Tc17) cells are enriched in active lesions of patients with multiple sclerosis (MS), suggesting a role the pathogenesis autoimmunity. Here we show that amelioration MS by dimethyl fumarate (DMF), mechanistically elusive drug, associates suppression Tc17 cells. DMF treatment results reduced frequency Tc17, contrary to Th17 cells, and decreased ratio regulators RORC-to-TBX21, along shift towards cytotoxic T lymphocyte gene expression signature from patients....
Although the association between long-term exposure to PM2.5 and mortality has been evaluated intensively, little is known about socioeconomic disparity in association. We collected data on annual all-cause mortality, concentration, demographic characteristics of 2640 counties from two most recent Chinese censuses 2000 2010. applied difference-in-differences (DID) method estimate PM2.5-mortality for at different quartiles literacy rate, college urbanization rate GDP per capita, respectively....
Metabolic reprogramming is known as an emerging mechanism of chemotherapy resistance, but the metabolic signatures pancreatic ductal adenocarcinomas (PDACs) remain unclear. Here, we characterize metabolomic profile PDAC organoids and classify them into glucomet-PDAC (high glucose metabolism levels) lipomet-PDAC lipid levels). Glucomet-PDACs are more resistant to than lipomet-PDACs, patients with have a worse prognosis. Integrated analyses reveal that GLUT1/aldolase B...
Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression, thereby shaping tumor heterogeneity therapy response. In castration-resistant prostate (CRPC), intricacies behind androgen receptor (AR)-independent lineage plasticity remain unclear, leading a scarcity effective clinical treatments. Utilizing single-cell RNA sequencing on both human mouse samples, combined with whole-genome bisulfite...
Carboxylate-anion-based imidazolium ionic liquids (ILs) are powerful solvents for cellulose and lignin. However, little is known about their fundamental physicochemical properties. In this work, 1-butyl-3-methylimidazolium carboxylate ILs formate ([C4mim][HCOO]), acetate ([C4mim][CH3COO]), propionate ([C4mim][CH3CH2COO]), butyrate ([C4mim][CH3(CH2)2COO]), in which the alkyl chain length anions being varied contrast to more usual studies where cations varied, have been synthesized densities...
Injectable hydrogels with pH and glucose triggered drug release capability were synthesized based on biocompatible phenylboronic modified chitosan oxidized dextran through the formation of covalent imine bond phenylboronate ester. Rheological characterization demonstrated that gelation rate was rapid, moduli able to be tuned chemical composition as well concentration polymer solution. Anticancer drugs could incorporated inside hydrogel in situ gel forming process undergo a controlled by...
Glycogen metabolism commonly altered in cancer is just beginning to be understood. Phosphoglucomutase 1 (PGM1), the first enzyme glycogenesis that catalyzes reversible conversion between glucose 1-phosphate (G-1-P) and 6-phosphate (G-6-P), participates both breakdown synthesis of glycogen. Here, we show PGM1 down-regulated hepatocellular carcinoma (HCC), which associated with malignancy poor prognosis HCC. Decreased expression obstructed pathway, leads increased flow into glycolysis, thereby...
Abstract Background While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood. Methods We conducted cell proliferation assays on CRC cells with or without depletion squalene epoxidase (SQLE), 5-fluorouracil (5-FU) treatment. Additionally, xenograft mouse model was utilized to explore impact SQLE chemosensitivity 5-FU. RNA-sequencing analysis and immunoblotting were performed...