A5007562617- Aquaculture Nutrition and Growth
- Invertebrate Immune Response Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Crustacean biology and ecology
- Neurobiology and Insect Physiology Research
- Reproductive biology and impacts on aquatic species
- Physiological and biochemical adaptations
- Genetic diversity and population structure
- Animal Genetics and Reproduction
- Insect Resistance and Genetics
- Epigenetics and DNA Methylation
- Aquaculture disease management and microbiota
- Organic Food and Agriculture
- Health disparities and outcomes
- Aquatic life and conservation
- Fish Biology and Ecology Studies
- Identification and Quantification in Food
- High Altitude and Hypoxia
- Global trade, sustainability, and social impact
- Metabolomics and Mass Spectrometry Studies
- Sperm and Testicular Function
- Marine Biology and Environmental Chemistry
- Parasite Biology and Host Interactions
- Cardiovascular Health and Risk Factors
- Genetics, Aging, and Longevity in Model Organisms
Nanjing Agricultural University
2010-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Chinese Academy of Fishery Sciences
2016-2025
Fudan University
2024-2025
State Key Laboratory of Genetic Engineering
2025
Dalian Ocean University
2025
West China Medical Center of Sichuan University
2025
Ningxia Medical University
2009-2024
Inner Mongolia Agricultural University
2024
Ningxia Center for Diseases Prevention and Control
2024
Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. By integrating human population-level phenotypic and multi-omics data as well two humanized mouse models, demonstrate the causal roles SVs: one SV that emerges at common ancestor modern humans, Neanderthals, Denisovans GSDMD for bone mineral...
Background The oriental river prawn, Macrobrachium nipponense, is an important aquaculture species in China, even whole of Asia. androgenic gland produces hormones that play crucial roles sexual differentiation to maleness. This study the first de novo M. nipponense transcriptome analysis using cDNA prepared from mRNA isolated gland. Illumina/Solexa was used for sequencing. Methodology and Principal Finding total volume RNA sample more than 5 ug. We generated 70,853,361 high quality reads...
Quantitative real-time PCR (qPCR) is widely used in molecular biology, although the accuracy of quantitative results determined by stability reference genes used. Recent studies have investigated suitable for some crustaceans under various conditions, but Macrobrachium nipponense are currently lacking. In this study, we selected following seven from among 35 commonly housekeeping as candidate qPCR temporal and spatial expression: EIF (eukaryotic translation initiation factor 5A), 18S (18S...
This review explores the role of microorganisms and metabolites in human breast milk their impact on neonatal health. Breast serves as both a primary source nutrition for newborns contributes to development maturation digestive, immunological, neurological systems. It has potential reduce risks infections, allergies, asthma. As our understanding properties advances, there is growing interest incorporating its benefits into personalized infant strategies, particularly situations which...
The oriental river prawn, Macrobrachium nipponense, is an economically important shrimp in China. Male prawns have higher commercial value than females because the former grow faster and reach larger sizes. It therefore to reveal sex-differentiation development mechanisms of prawn enable genetic improvement.We sequenced 293.3 Gb raw Illumina short reads 405.7 Pacific Biosciences long reads. final whole-genome assembly Oriental was ∼4.5 size, with predictions 44,086 protein-coding genes. A...
Abstract Leaf senescence is a complex and precise regulatory process that correlated with numerous internal environmental factors. tightly related to the redistribution of nutrients, which significantly affects productivity quality, especially in crops. Evidence shows mediation transcriptional regulation by WRKY transcription factors vital for fine‐tuning leaf senescence. However, underlying mechanisms involvement are still unclear wheat. Using RNA sequencing data, we isolated novel factor,...
Abstract Background Macrobrachium nipponense is an economically important species of freshwater shrimp in China. Unlike other marine shrimps, the ovaries adult female M. can mature rapidly and periodically during reproductive period, but resulting high stocking densities environmental deterioration negatively impact harvest yield economic benefits. To better understand ovary development , we performed systematic transcriptome sequencing five different stages ovarian maturation. Results We...
In this study, two Sxl gene homologs, designated as Mnsxl1 and Mnsxl2, were cloned characterized from the freshwater prawn Macrobrachium nipponense by rapid amplification of cDNA ends.The deduced amino acid sequences Mnsxl2 showed high sequence homology to insect contained conserved domains in RNA-binding motifs.Real-time quantitative reverse transcription-polymerase chain reaction (RT-QPCR) that genes expressed all investigated tissues, with highest level expression intestine liver.RT-QPCR...
Abstract The oriental river prawn, Macrobrachium nipponense , is an important commercial aquaculture resource in China. During breeding season, short ovary maturation cycles of female prawns cause multi-generation reunions ponds and affect the growth females representing individual miniaturization (known as autumn -propagation). These reproductive characteristics pose problems for large - scale farming. To date, molecular mechanisms reproduction regulation M . remain unclear. address this...
The doublesex and mab-3 related transcription factor (DMRT) gene family involvement in sex development is widely conserved from invertebrates to humans. In this study, we identified a DM (Doublesex/Mab-3)-domain Macrobrachium nipponense, which named MniDMRT11E because it has many similarities phylogenetically close relationships with the arthropod DMRT11E. Amino acid alignments structural prediction uncovered conservation putative active sites of domain. Real-time PCR analysis showed that...
White spot syndrome virus (WSSV) is one of the most devastating pathogens cultured shrimp, responsible for massive loss its commercial products worldwide. The oriental river prawn Macrobrachium nipponense an economically important species that widely farmed in China and adult prawns can be infected by WSSV. However, molecular mechanisms host pathogen interaction remain unknown. There urgent need to learn between M. WSSV which will able offer a solution controlling spread Next Generation...
The oriental river prawn Macrobrachium nipponense is an important freshwater economic species in China, producing huge benefits. However, M. shows lower alkali tolerance than fish species, thus genetic selection urgently needed order to improve this species. In the present study, effects of alkalinity exposure on hepatopancreas were measured under concentrations 0 (control), 4, 8, and 12 mmol/L with time 96 h through histological observations, measurement antioxidant enzymes, metabolic...
This study investigates the role of lysosomal acid lipase (LIPA) in sex hormone regulation and gonadal development Macrobrachium nipponense. The full-length Mn-LIPA cDNA was cloned, its expression patterns were analyzed using quantitative real-time PCR (qPCR) various tissues developmental stages. Higher levels observed hepatopancreas, cerebral ganglion, testes, indicating potential involvement differentiation development. In situ hybridization experiments revealed strong signaling...
Genomic structural variants (SVs) are a major source of genetic diversity in humans. Although numerous studies explore SV across global populations and their potential impacts, validation using model systems needed to confirm the reported genotype-phenotype associations. Here, through long-read sequencing 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many predicted be functionally important. Our analysis unveils multifaceted origins these SVs within...