A5111626147- Probiotics and Fermented Foods
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Protein Hydrolysis and Bioactive Peptides
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Enzyme Production and Characterization
- Milk Quality and Mastitis in Dairy Cows
- Digestive system and related health
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Meat and Animal Product Quality
- Animal Diversity and Health Studies
- Food Quality and Safety Studies
- Diet and metabolism studies
- Animal Nutrition and Physiology
- Oral microbiology and periodontitis research
- Enterobacteriaceae and Cronobacter Research
- Bacterial Genetics and Biotechnology
- Biochemical Analysis and Sensing Techniques
- Microbial Metabolism and Applications
- Fermentation and Sensory Analysis
- Gastrointestinal motility and disorders
- Biopolymer Synthesis and Applications
- Microbial Metabolic Engineering and Bioproduction
Inner Mongolia Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2018-2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
Huazhong Agricultural University
2024
Yale University
2022
Ministry of Education of the People's Republic of China
2009-2021
Fifth Tianjin Central Hospital
2021
Dalian Polytechnic University
2020
Central South University of Forestry and Technology
2019
Abstract Lactobacilli are a diverse group of species that occupy nutrient-rich niches associated with humans, animals, plants and food. They used widely in biotechnology food preservation, being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear identity uncertain relationships between them other commercially important lactic acid bacteria. The capacity for biotransformations catalysed is an untapped resource. Here we report the genome...
Abstract Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular symbionts maintaining health their hosts. Here we performed a large structural survey fecal in 314 young adults, covering 20 rural urban cohorts from 7 ethnic groups living 9 provinces throughout China. Canonical analysis unweighted UniFrac principal coordinates clustered subjects mainly...
Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), functional and metabolic mechanisms microbes associated PCOS, as well potential microbial biomarkers, not yet been identified. To address this gap, we designed two-phase experiment in which performed shotgun metagenomic sequencing monitored parameters, gut-brain mediators, sex hormones PCOS patients. In first stage, identified an imbalance patients, observing that...
Lactobacillus plantarum IMAU10014 was isolated from koumiss that produces a broad spectrum of antifungal compounds, all which were active against plant pathogenic fungi in an agar plate assay. Two major compounds extracted the cell-free supernatant broth L. IMAU10014. 3-phenyllactic acid and Benzeneacetic acid, 2-propenyl ester carried out by HPLC, LC-MS, GC-MS, NMR analysis. It is first report lactic bacteria produce ester. Of these, products also have activity, namely Botrytis cinerea,...
Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, however concern in both treatment efficacy and neonate safety. Here, using bovine mastitis most costly disease dairy industry as a model, we showed that intestinal microbiota alone can lead mastitis.
Lactobacilli are widely used as starter cultures or probiotics in yoghurt, cheese, beer, wine, pickles, preserved food, and silage. They generally recognized safe (GRAS). However, recent studies have shown that some lactic acid bacteria (LAB) strains carry antibiotic resistance genes resistant to antibiotics. Some of them may even transfer their intrinsic other LAB pathogens via horizontal gene transfer, thus threatening human health. A total 33 Lactobacillus was isolated from fermented milk...
From 16 samples of traditional fermented koumiss collected in Inner Mongolia Autonomous Region China, forty-eight lactobacilli strains were isolated and phenotypically characterized by their abilities to ferment different carbohydrates additional biochemical tests. The dominant species identified as L. casei (17 strains), helveticus (10 strains) plantarum (8 with a lower frequency isolation for coryniformis subsp. (5 paracasei (3 kefiranofaciens (2 curvatus (1 strain), fermentum strain) W....
Breast milk is the main source of nutrition for infants; it contains considerable microflora that can be transmitted to infant endogenously or by breastfeeding, and plays an important role in maturation development immune system. In this study, we isolated identified lactic acid bacteria (LAB) from human colostrum, screened 2 strains with probiotic potential. The LAB 40 colostrum samples belonged 5 genera: Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Staphylococcus. We also...
Previously, we demonstrated that the flavor of milk fermented with Lactobacillus delbrueckii subsp. bulgaricus (IMAU20401) and Streptococcus thermophilus (IMAU40133) at a 1:1000 ratio was superior to other ratios two strains. In this study, plantarum P-8 used as probiotic bacterium. Six (1:1, 1:5, 1:10, 1:50, 1:100, 1:1000) L. yogurt starter were evaluated. A total 66 volatile compounds including aldehydes, ketones, acids, alcohols, esters, aromatic identified in six different 0 d storage....
Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety depression. Our previous study showed that ingesting probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress stressed adults. The current was a follow-up work aiming investigate functional role gut metagenomes in observed beneficial effects. fecal (n = 43) placebo 36) receivers were analyzed depth. microbiomes group at 0...
As an effective means to improve quality of life and prevent diseases, the demand for probiotics related products has increased in recent years. However, it is still unclear whether a particular probiotic strain will have similar beneficial effects on healthy adults from different regions. In this study, Lactobacillus casei Zhang (LCZ) was consumed by six Asian regions changes gut microbiota were compared using PacBio single molecule, real-time (SMRT) sequencing technology based samples...
Despite recent advances in therapeutic strategies and drug treatments (e.g., statins) for coronary artery disease (CAD), CAD-related mortality morbidity remain high. Active bidirectional interactions between the gut microbiota heart implicate that probiotic application could be a novel strategy CAD.
Metformin is a common drug for the management of type 2 diabetes mellitus; however, it causes various adverse gastrointestinal effects, especially after prolonged treatment. It thus interest to identify an adjuvant treatment that synergizes with efficacy metformin while mitigating its effects. Since previous evidence supports gut microbiota target metformin, this study investigated beneficial effect and mechanism coadministration probiotics in mellitus by conducting 3-month randomized,...