A5100417601- Smoking Behavior and Cessation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Topic Modeling
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Social Media in Health Education
- Obesity, Physical Activity, Diet
- Impact of Technology on Adolescents
- Consumer Attitudes and Food Labeling
- SARS-CoV-2 and COVID-19 Research
- Misinformation and Its Impacts
- Diabetes Management and Education
- Media Studies and Communication
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Media Influence and Health
- Influenza Virus Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tracheal and airway disorders
- COVID-19 epidemiological studies
- Diabetes Treatment and Management
- Pregnancy and preeclampsia studies
- Sexuality, Behavior, and Technology
- Soybean genetics and cultivation
- Pediatric health and respiratory diseases
University of Rochester Medical Center
2015-2025
Georgetown University Medical Center
2015-2025
Georgetown University
2015-2025
Inner Mongolia University of Technology
2016-2025
Pfizer (United States)
2016-2025
Beijing Red Cross Blood Center
2018-2025
Beijing Tongren Hospital
2025
Capital Medical University
2025
Ministry of Industry and Information Technology
2025
Central South University
2025
Stability of multiple testing procedures, defined as the standard deviation total number discoveries, can be used an indicator variability procedures. Improving stability procedures help to increase consistency findings from replicated experiments. Benjamini-Hochberg's and Storey's q-value are two commonly for controlling false discoveries in genomic studies. procedure has higher power lower than procedure. To improve upon maintain its high data analysis, we propose a new procedure, named...
Exposure to visual posts featuring e-cigarette products on social media is associated with increased use among US adolescents. Instagram the largest source of marketing, where influencers-for example, bloggers, brand ambassadors-post promotional materials. This study analysed network brands and influencers Instagram, characterising most central players in marketing.We tracked public profiles who posted content 2020, had over 1000 followers high user engagement rate (ratio likes comments...
Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described adipocyte-specific proteins with lipid hydrolase activity. Using bioinformatics, we identified three additional family members (GS2, GS2-Like, PNPLA1). Here, report on the expression, regulation, activity of GS2 GS2-Like compared Desnutrin/ATGL. is expressed regulated in manner similar to Adiponutrin; however, absolute levels mRNA are significantly lower than those or...
New formulations, increased marketing, and wider recognition of declining testosterone levels in older age may have contributed to testing supplementation many countries.Our objective was describe treatment men the United Kingdom States.This a retrospective incident user cohort.We evaluated commercial Medicare insurance claims from States general practitioner healthcare records for years 2000 through 2011.We identified 410,019 US 6858 UK who initiated formulation as well 1,114,329 66,140...
Extracellular vesicles (EVs) play a vital role in normal lung physiology to maintain homeostasis the airways via intercellular communication. EVs include exosomes and microvesicles, are characterized by their phospholipid bilayers. have been recognized as novel circulating biomarkers of disease, which released different cell types. In this study, we used EV isolation purification methods characterize plasma-derived miRNAs from non-smokers, smokers patients with COPD. A small RNA sequencing...
Obesity, physical activity, and sedentary behavior in childhood are important indicators of present future health associated with school-related outcomes such as academic achievement, behavior, peer relationships, self-esteem. Using logistic regression models that controlled for gender, age, ethnicity/race, socioeconomic status, we investigated the likelihood youth learning disabilities (LD) attention-deficit/hyperactivity disorder (ADHD) obese, physically active, using a nationally...
Background Wheezing is a symptom of potential respiratory disease and known to be associated with smoking. Electronic cigarette use (‘vaping’) has increased exponentially in recent years. This study examined the cross-sectional association vaping wheezing related symptoms compare this smokers dual users. Methods The Population Assessment Tobacco Health wave 2 data collected from October 2014 2015 28 171 adults were used. self-reported relative users tobacco electronic cigarettes studied...
Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We sought determine whether genome-wide lung profiles smokers COPD were significantly different from non-smokers. isolated parenchymal tissues including eight lifelong non-smokers, current...
Coronavirus 3C-like protease (3CLPro) is a highly conserved cysteine employing catalytic dyad for its functions. 3CLPro essential to the viral life cycle and, therefore, an attractive target developing antiviral agents. However, detailed mechanism of coronavirus remains largely unknown. We took integrated approach X-ray crystallography, mutational studies, enzyme kinetics study, and inhibitors gain insights into mechanism. Such experimental work supplemented by computational including...
Abstract Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand possible mechanisms that mediate toxicity and pulmonary health effects of e-cigs. We hypothesized sub-chronic e-cig exposure induces inflammatory response dysregulated repair/extracellular matrix (ECM) remodeling, which occur through α7 nicotinic acetylcholine receptor (nAChRα7)....
As one of the most prevalent chronic diseases in United States, diabetes, especially type 2 affects health millions people and puts an enormous financial burden on US economy. We aimed to develop predictive models identify risk factors for which could help facilitate early diagnosis intervention also reduce medical costs.We analyzed cross-sectional data 138,146 participants, including 20,467 with from 2014 Behavioral Risk Factor Surveillance System. built several machine learning predicting...
Brain health attracts more recent attention as the population ages. Smartphone-based gait sensing and analysis can help identify risks of brain diseases in daily life for prevention. Existing approaches mainly hand-craft temporal features or developing CNN-based feature extractors, but they are either prone to lose some inconspicuous pathological information only dedicated a single disease screening. We discover that relationship between segments be used principle generic indicator quantify...
RNA-seq is a high-throughput sequencing technology widely used for gene transcript discovery and quantification under different biological or biomedical conditions. A fundamental research question in most experiments the identification of differentially expressed genes among experimental conditions sample groups. Numerous statistical methods differential analysis have been proposed since emergence assay. To evaluate popular open source R Bioconductor packages, we conducted multiple...
Metformin is a common drug for the management of type 2 diabetes mellitus; however, it causes various adverse gastrointestinal effects, especially after prolonged treatment. It thus interest to identify an adjuvant treatment that synergizes with efficacy metformin while mitigating its effects. Since previous evidence supports gut microbiota target metformin, this study investigated beneficial effect and mechanism coadministration probiotics in mellitus by conducting 3-month randomized,...
ABSTRACT HLA‐DRB1*03:72:02 differs from HLA‐DRB1*03:01:01:01 by one nucleotide substitution at position 247 (codon 54) in exon 2.
Background: Personal mobile phones and other personal communication devices (smartphones tablet computers) provide users with an ever-increasing number diversity of non-work-related activities while at work. In hospitals, where the vigilance health care workers is essential for patient care, potential distraction these could be hazardous to patients. Objective: The objective this study was determine frequency use among hospital registered nurses. Methods: March 2014, a previously validated...