A5054986937- Bone health and treatments
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Immunotoxicology and immune responses
- Veterinary Orthopedics and Neurology
- Orthopaedic implants and arthroplasty
- Fibroblast Growth Factor Research
- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- Retinal Development and Disorders
- Forensic Anthropology and Bioarchaeology Studies
- Metabolism and Genetic Disorders
- Kruppel-like factors research
- Bone health and osteoporosis research
- dental development and anomalies
- Animal testing and alternatives
- Pregnancy-related medical research
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Hip disorders and treatments
- Dental Trauma and Treatments
- Body Composition Measurement Techniques
- Veterinary Equine Medical Research
- bioluminescence and chemiluminescence research
- Heterotopic Ossification and Related Conditions
WuXi AppTec (United States)
2024
Pfizer (United States)
2013-2022
Procter & Gamble (United States)
2007
Cornell University
1996-1997
Procter & Gamble (Netherlands)
1996
University of Florida Health Science Center
1994
University of Florida
1990
University of California San Diego Medical Center
1990
Aims To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF ‐05231023, a long‐acting fibroblast growth factor 21 ( FGF 21) analogue, in obese people with hypertriglyceridaemia on atorvastatin, or without type 2 diabetes. Methods Participants received ‐05231023 placebo intravenously once weekly for 4 weeks. Safety (12‐lead ECG s, vital signs, adverse events [ AEs ], laboratory tests) longitudinal weight assessments were performed. Blood samples collected...
Objective To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Methods Male Lewis underwent MMT surgery and were treated weekly (0.1, 1 or 10 mg/kg), isotype control vehicle for 7, 14 28 days. Gait deficiency was measured to assess weight-bearing operated limb. Joint damage assessed via histopathology. A second arm, delayed onset...
Debilitating pain is the primary clinical feature of osteoarthritis (OA) that drives enormous healthcare costs. Osteoarthritis-related often treated with non-steroidal anti-inflammatory drugs (NSAIDs), which effectively relieve and inflammation by inhibition prostaglandin synthesis. Antibodies directed against nerve growth factor (NGF) were tested some time ago as an alternative potential analgesic for musculoskeletal pain, including osteoarthritis-related pain. Unfortunately, development...
A severe, progressive myopathy developed in an 11-year-old, phosphofructokinase (PFK)-deficient, male, English Springer Spaniel dog. Results from a routine neurological examination were normal. Examination of histologic sections skeletal muscle revealed large accumulations material some myofibers. These deposits pale, basophilic, somewhat flocculent, and slightly granular with hematoxylin eosin stain. Most fascicles examined limb trunk muscles affected to degree, up 10% fibers being...
Given the proven utility of natriuretic peptides as serum biomarkers cardiovascular maladaptation and dysfunction in humans high cross-species sequence conservation atrial peptides, have potential to serve translational for identification cardiotoxic compounds during multiple phases drug development. This work evaluated compared response N-terminal proatrial peptide (NT-proANP) probrain (NT-proBNP) rats exercise-induced drug-induced increases cardiac mass after chronic swimming or daily oral...
We have used immunocytochemistry and in situ hybridization to examine the expression of photoreceptor specific genes retinas normal dogs those affected with hereditary cone degeneration (cd), a rare autosomal recessive disorder that selectively affects cones. In thecdretina, disease begins early life; cones are lost by extrusion nucleus into inner segment, later, displacement nucleus, surrounded thin rim cytoplasm, interphotoreceptor space. Two micrometer sections from superior inferior...
Duchenne muscular dystrophy results from mutation of the dystrophin gene, causing skeletal and cardiac muscle loss function. The mdx mouse model is widely utilized to evaluate potential therapeutic regimens modulate function associated with mutation. Importantly, progressive diaphragm most consistent striated effect observed in model, which same as patients suffering dystrophy.Using we have evaluated that corticotrophin releasing factor 2 receptor (CRF2R) agonist treatment has on function,...
Progressive rod-cone degeneration (prcd) is a late-onset hereditary retinal characterized by normal development of photoreceptors prior to and death visual cells. We reported previously that expression opsin mRNA protein decreases cell degeneration. To examine the specificity this reduction, we have used immunocytochemistry correlate photoreceptor-specific with disease progression. Eyes from light-adapted age-matched control andprcd-affected dogs were fixed in paraformaldehyde, embedded...
Evaluation of skeletal muscle frequently combines morphologic and morphometric techniques. As is the case with many organ systems, has limited responses to insult or injury. Over past several years, crucial interactions between muscle, bone, nervous system have been described. The aim this lecture was give attendees necessary background information in basic morphology, important species differences, introduction biomarkers, approaches evaluation, examples findings typical
Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials anti-NGF antibodies, some patients reported unexpected adverse events requiring total joint replacements, resulting a partial hold on all NGF inhibitors. Three nonclinical toxicology studies were conducted to evaluate the effects tanezumab or murine precursor muMab911 selected bone and endpoints biomarkers cynomolgus monkeys, Sprague-Dawley rats, C57BL/6 mice. Joint...
Mechanical and metabolic relationships of muscle lacking phosphofructokinase (PFKD) activity were compared with having normal (NORM) by using the gastrocnemius-plantaris group isolated circulation in situ. Muscle contractile properties similar both groups. Initial power output (W) during repetitive tetanic (200 ms, 50 impulses/s) isotonic contractions was groups; however, W declined significantly more (30–80%) PFKD than NORM over time, a constant O2 uptake (VO2)/W. Despite substrate...
Cancellous bone has high metabolic activity compared to many other compartments and can be affected not only by changes in physeal but also perturbations homeostasis caused physiology or on-target pharmacology. Examples of several types resulting morphologic findings were presented; if known, the pathways causing discussed.
Abstract The use of Wistar Han (WH) rats in regulatory toxicology studies, including juvenile animal is increasing. current study was performed to characterize femur development neonatal and WH rats. Beginning on postnatal day (PND) 4 through PND 50, groups ( n = 5/sex) were evaluated for the ossification by Alizarin Red S staining, micro‐computed tomography (micro‐CT) imaging, microscopic examination, Collagen X immunostaining. focus these evaluations limited proximal head, neck, greater...
The title of the 2016 Society Toxicologic Pathology (STP) Symposium was "Basis and Relevance Variation in Responses." Many factors may contribute to variation toxicologic responses can confound results, complicate interpretation data, interfere with reproducibility, make extrapolation humans problematic. This brief overview summarizes speaker presentations from each session which describes important that impact nonclinical discovery developmental toxicity studies. In addition, summaries...