A5100386202- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Pharmacological Receptor Mechanisms and Effects
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- Luminescence and Fluorescent Materials
- Neuropeptides and Animal Physiology
- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Photochromic and Fluorescence Chemistry
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Free Radicals and Antioxidants
- Porphyrin Metabolism and Disorders
- Conducting polymers and applications
- Polyamine Metabolism and Applications
- Hydrogen Storage and Materials
- Folate and B Vitamins Research
- Organic Electronics and Photovoltaics
- Chemical Reaction Mechanisms
First Bethune Hospital of Jilin University
2024
Sun Yat-sen University
2010-2024
Beijing Normal University
2015-2023
Shenyang University of Chemical Technology
2013-2023
Inner Mongolia Normal University
2023
Inner Mongolia University of Technology
2021
Jilin Medical University
2020
Jilin University
2020
Tsinghua University
2020
Institute of Theoretical Physics
2020
Abstract With the aim of mimicking biological machines, in which delicate arrangement nanomechanical units lead to output specific functions upon external stimulus, construction dual stimuli-responsive rotaxane-branched dendrimers was realized this study. Starting from a switchable organometallic [2]rotaxane precursor, employment controllable divergent approach allowed for successful synthesis family up third generation with 21 rotaxane moieties located on each branch. More importantly,...
Coronavirus 3C-like protease (3CLPro) is a highly conserved cysteine employing catalytic dyad for its functions. 3CLPro essential to the viral life cycle and, therefore, an attractive target developing antiviral agents. However, detailed mechanism of coronavirus remains largely unknown. We took integrated approach X-ray crystallography, mutational studies, enzyme kinetics study, and inhibitors gain insights into mechanism. Such experimental work supplemented by computational including...
Starting from a novel rotaxane building block with dendrimer growth sites being located at both the wheel and axle component, we realized successful construction of new family rotaxane-branched dendrimers, i.e., Type III-C up to fourth generation as highly branched [46]rotaxane through controllable divergent approach. In resultant components units are on branches well branching points, making them excellent candidates mimic amplified collective molecular motions. Thus, taking advantage urea...
By simple ligand exchange of the cationic transition-metal complexes [(Cp*)M(acetone)3 ](OTf)2 (Cp*=pentamethylcyclopentadienyl and M=Ir or Rh) with pillar[5]arene, mono- polynuclear pillar[5]arenes, a new class metalated host molecules, is prepared. Single-crystal X-ray analysis shows that charged cations are directly bound to outer π-surface aromatic rings pillar[5]arene. One triflate anions deeply embedded within cavity trinuclear which different host-guest behavior most pillar[5]arenes....
The reactive force field (ReaxFF) method is employed in the molecular dynamics (MD) simulation of oleic-type triglyceride (OTG) pyrolysis for first time. complex mechanism OTG at high temperature, especially focusing on multichannel pathways and radical-related evolution mechanisms products, intensively investigated atomistic level by performing a series ReaxFF MD simulations. On basis trajectory analysis, we find that initiation decomposition through C–O bond fission to release straight...
As a common phenomenon in biological systems, supramolecular transformations of biomacromolecules lead to specific functions as outputs, which thus inspire people construct biomimetic dynamic systems through transformation strategy. It should be noted that well-modulating the artificial macromolecules fine-tune their properties is great significance yet still remains big challenge polymer chemistry. In this study, combination coordination-driven self-assembly and postassembly ring-opening...
Slip sliding away: Foldamers (see picture, red) can function as modular stoppers to regulate the slippage and de-slippage of pseudorotaxanes switching kinetics metastability bistable rotaxanes. By simply changing solvent or length hydrogen-bonded foldamer, lifetime metastable co-conformation state be increased dramatically, from several minutes long days.
A new heterometallic macrocycle with photochromic properties was successfully constructed through coordination-driven self-assembly, which features interesting photoswitchable FRET behaviour.
Chiral cyclic amines can be prepared via intramolecular reductive amination of N-Boc-protected amino ketones in a one-pot process. With the complex iridium and f-spiroPhos as catalyst, range are smoothly transformed into chiral free high yields excellent enantioselectivities (up to 97% ee). Moreover, this method also successfully applied synthesis κ-opioid receptor selective antagonist, (S)-1.
A new discrete supramolecular metallacage functionalized with an alkynylplatinum(ll) 2,6-bis(benzimidazole-2'-yl)-pyridine (bzimpy) moiety has been successfully constructed via coordination-driven self-assembly. study on the hierarchical self-assembly behavior of obtained revealed that it displayed a solvent-induced emission switch accompanied by enhancement intensity as result change in intermolecular Pt···Pt and π-π interactions. More interestingly, found to spontaneously self-assemble...
This study shows that the twisted cucurbit[14]uril features two different cavities, which can encapsulate or even three guest molecules with suitable shape and size, forming a special inclusion complex.
An electron-rich catalyst (Pt 1 Pd(111)/TiO 2 ) with a prominent facet dependence displays extraordinary catalytic properties in the direct synthesis of H O .
Small organic non-viral gene vectors with the structural combinations of (aliphatic chain)–naphthalimide–[12]aneN<sub>3</sub> (<bold>11a</bold>, <bold>b</bold>) and naphthalimide–(aliphatic chain)–[12]aneN<sub>3</sub> (<bold>12a–c</bold>) were synthesized fully characterized.
A highly enantioselective hydrogenation of cyclic imines has been successfully realized providing chiral amines with excellent enantioselectivities in the absence any additive.
Bifunctional molecules with different combinations of [12]aneN<sub>3</sub> and coumarin moieties were successfully applied in DNA condensation gene transfection.
Abstract In the present study, electronic energy transfer pathways in trimeric and hexameric aggregation state of cyanobacteria C‐phycocyanin (C‐PC) were investigated term Förster theory. The corresponding excited states transition dipole moments phycocyanobilins (PCBs) located into C‐PC examined by model chemistry gas phase at time‐dependent density functional theory (TDDFT), configuration interaction‐singles (CIS), Zerner's intermediate neglect differential overlap (ZINDO) levels,...