A5041339388- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Allergic Rhinitis and Sensitization
- Diabetes and associated disorders
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Advanced Sensor and Energy Harvesting Materials
- Circular RNAs in diseases
- RNA Research and Splicing
- Conducting polymers and applications
- Inhalation and Respiratory Drug Delivery
The University of Queensland
2019-2025
East China Jiaotong University
2025
China Three Gorges University
2025
Hunan University
2025
Australian National University
2010-2024
Renji Hospital
2018-2024
Children's Medical Research Institute
2022-2024
Monash University
2011-2024
Discovery Institute
2024
Xiangya Hospital Central South University
2023-2024
During T cell–dependent responses, B cells can either differentiate extrafollicularly into short-lived plasma or enter follicles to form germinal centers (GCs). Interactions with follicular helper (Tfh) are required for GC formation and selection of somatically mutated cells. Interleukin (IL)-21 has been reported play a role in Tfh cell growth, survival, isotype switching. To date, it is unclear whether the effect IL-21 on predominantly consequence this cytokine acting directly if influences...
Production of high-affinity pathogenic autoantibodies appears to be central the pathogenesis lupus. Because normal antibodies arise from germinal centers (GCs), aberrant selection GC B cells, caused by either failure negative or enhanced positive follicular helper T (T(FH)) is a plausible explanation for these autoantibodies. Mice homozygous san allele Roquin, which encodes RING-type ubiquitin ligase, develop GCs in absence foreign antigen, excessive T(FH) cell numbers, and features We...
One-pot approach to couple the crystallization of CaCO3 nanoparticles and in situ symmetry-breaking assembly these crystallites into hollow spherical shells was developed under templating effect a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing release by pH value-sensitive structure enhancing cytotoxicity increasing cellular uptake, perinuclear accumulation, nuclear entry.
Abstract High expression of CXCR5 is one the defining hallmarks T follicular helper cells (TFH), a CD4 Th cell subset that promotes germinal center reactions and selection affinity maturation B cells. also expressed on 20–25% peripheral blood human central memory (TCM), although definitive function these not fully understood. The constitutive TFH fraction circulating TCM suggests CXCR5+ may represent specialized memory-type programmed for homing to follicles providing help. To verify this...
T follicular helper cells (Tfh cells) localize to follicles where they provide growth and selection signals mutated germinal center (GC) B cells, thus promoting their differentiation into high affinity long-lived plasma memory cells. T-dependent cell also occurs extrafollicularly, giving rise unmutated that are important for early protection against microbial infections. Bcl-6 expression in has been shown be essential the formation of Tfh GC but little is known about its requirement...
Objectives Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-blind and placebo-controlled trial is required to formally evaluate the safety efficacy therapy. Methods randomised, was designed treat 60 patients with active SLE. These received either (n=30) or placebo standard for 12 weeks, were followed up additional weeks. at a dose 1 million IU administered subcutaneously every other day 2 weeks by...
Naturally acquired immunity to malaria develops only after years of repeated exposure Plasmodium parasites. Despite the key role antibodies play in protection, cellular processes underlying slow acquisition remain unknown. Using mouse models, we show that severe infection inhibits establishment germinal centers (GCs) spleen. We demonstrate induces high frequencies T follicular helper (Tfh) cell precursors but results impaired Tfh differentiation. expression Bcl-6 and IL-21, precursor cells...
Despite multiple immunotherapeutic technologies that achieve potent T cell activation, effector cells still lack efficiency because of the highly immunosuppressive conditions in tumor microenvironment. Inspired by recent advances nano-sized secreted vesicles known as exosomes therapeutic agents and research revealing circulating cancer have a “homing” capacity to return main sites, we generated macrophage-tumor hybrid cells. We introduced nuclei isolated from into activated M1-like...
BACKGROUND. Marked progress is achieved in understanding the physiopathology of coronavirus disease 2019 (COVID-19), which caused a global pandemic. However, CD4+ T cell population critical for antibody response COVID-19 poorly understood.
Transcriptomic analysis plays a key role in biomedical research. Linear dimensionality reduction methods, especially principal-component (PCA), are widely used detecting sample-to-sample heterogeneity, while recently developed non-linear such as t-distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation projection (UMAP), can efficiently cluster heterogeneous samples single-cell RNA sequencing analysis. Yet, the application of t-SNE UMAP bulk transcriptomic...
Glucose metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated impact HIV infection on key processes that regulate glucose uptake primary CD4 CD8