A5014346457- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Nanoparticles: synthesis and applications
- Microplastics and Plastic Pollution
- Aquaculture Nutrition and Growth
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Physiological and biochemical adaptations
- Atherosclerosis and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Recycling and Waste Management Techniques
- Sphingolipid Metabolism and Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Immune cells in cancer
Shanghai Jiao Tong University
2008-2024
Chinese Academy of Sciences
2008-2024
Peking University
2013-2024
Center for Excellence in Molecular Cell Science
2016-2024
Universiti Sains Malaysia
2023-2024
Sichuan Agricultural University
2020-2024
Shanghai Children's Medical Center
2024
Yonker Environmental Protection (China)
2023
Xinjiang Academy of Agricultural Sciences
1994-2023
University of Chinese Academy of Sciences
2018-2022
Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported that PKM2 also regulates apoptosis. However, mechanisms underlying such a remain elusive. Here we show translocates to mitochondria under oxidative stress. In mitochondria, interacts with phosphorylates Bcl2 at threonine (T) 69. This phosphorylation prevents binding Cul3-based E3 ligase subsequent degradation Bcl2. A chaperone protein,...
Abstract Purpose: Antiangiogenic therapy is effective in blocking vascular permeability, inhibiting proliferation, and slowing tumor growth, but studies multiple cancer types have shown that tumors eventually acquire resistance to blockade of blood vessel growth. Currently, the mechanisms by which this occurs are not well understood. Experimental Design: In study, we evaluated effects neutrophils on glioma biology both vitro vivo determined target genes promote malignant phenotype during...
Gut microbiota can influence the aging process and may modulate aging-related changes in cognitive function. Trimethylamine-N-oxide (TMAO), a metabolite of intestinal flora, has been shown to be closely associated with cardiovascular disease other diseases. However, relationship between TMAO aging, especially brain not fully elucidated. To explore we analysed plasma levels both humans mice administered exogenous 24-week-old senescence-accelerated prone mouse strain 8 (SAMP8) age-matched...
Abstract Purpose: Antiangiogenic therapy reduces vascular permeability and delays progression but may ultimately promote an aggressive treatment-resistant phenotype. The aim of the present study was to identify mechanisms responsible for glioblastoma resistance antiangiogenic therapy. Experimental Design: Glioma stem cell (GSC) NSC11 U87 lines with acquired bevacizumab were developed from orthotopic xenografts in nude mice treated bevacizumab. Genome-wide analyses used changes tumor subtype...
Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates cell cycle, but other substrates their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation results in c-Src-mediated phosphorylation at Y59, which interacts with nuclear pyruvate M2 (PKM2). PKM2 S37, promotes PKM2-dependent β-catenin transactivation c-Myc-upregulated expression glycolytic genes GLUT1,...
6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD commonly upregulated and plays important roles many human cancers, while mechanism underlying such of remains elusive. Here we show upon EGFR activation, phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enhances activity increasing its binding affinity to therefore activates PPP...
Although serine metabolism plays a crucial role in the proliferation and survival of tumor cells, how it supports cell migration remains poorly understood. Phosphoglycerate dehydrogenase (PHGDH) catalyzes oxidation 3-phosphoglycerate to 3-phosphonooxypyruvate, first committed step de novo biosynthesis. Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 colorectal cancer (CRC) which enhanced activity recruiting chaperone protein, DnaJ homolog...
Abstract Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through production gut-derived metabolites. However, specific metabolites and their pathophysiological contribution cardiac hypertrophy or heart failure progression still remain unclear. N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine gut microbiota, was elevated with gradually increased risk mortality transplantation in a prospective...
Determining the mechanism of treatment failure VEGF signaling inhibitors for malignant glioma patients would provide insight into approaches to overcome therapeutic resistance. In this study, we demonstrate that human glioblastoma tumors failing bevacizumab have an increase in mean percentage p-STAT3-expressing cells compared samples taken from non-antiangiogenic therapy containing regimens. Likewise, murine xenograft models glioblastoma, gliomas resistant antiangiogenic was markedly...
Acute aortic dissection (AAD) is a life-threatening disease with high morbidity and mortality. Previous studies have showed that vascular smooth muscle cell (VSMC) phenotype switching modulates function AAD progression. However, whether an endogenous signalling system protects progression exists remains unknown. Our aim to investigate the role of Anxa1 in VSMC pathogenesis AAD.We first assessed expression levels by immunohistochemical staining control aorta tissue from mice. A strong...