A5100393724- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Berberine and alkaloids research
- Synthesis and Biological Activity
- Invertebrate Immune Response Mechanisms
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Physiological and biochemical adaptations
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- MicroRNA in disease regulation
- Bioactive natural compounds
- Blood disorders and treatments
- Adipose Tissue and Metabolism
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Telomeres, Telomerase, and Senescence
- Psoriasis: Treatment and Pathogenesis
- Bioactive Compounds and Antitumor Agents
- RNA and protein synthesis mechanisms
- Oral Health Pathology and Treatment
Shandong University
2014-2025
Jiangxi University of Traditional Chinese Medicine
2025
Sichuan Agricultural University
2016-2024
Central South University
2024
Jiangsu Provincial Center for Disease Control and Prevention
2020-2024
Taizhou University
2024
Hunan Agricultural University
2024
Jingchu University of Technology
2024
Peking University
2014-2024
Hunan Provincial Maternal and Child Health Hospital
2024
Abstract Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed embryo of lotus ( Nelumbo nucifera) exhibit potential anti-cancer activity. Here, we explored effects these on triple-negative breast cancer cells found that among three isoliensinine possesses most potent cytotoxic effect, primarily by inducing apoptosis. Interestingly, showed a much lower cytotoxicity against MCF-10A, normal human epithelial cell line. Further studies could significantly...
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and has a poor prognosis. We, here, report potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM. Berberine was found to have IC50 that much lower than temozolomide in vitro U87, U251, U118 glioblastoma cells. Although previous studies showed berberine primarily exerts its anticancer by inducing cell-cycle arrest, apoptosis, autophagy, we observed cells achieved through induction cellular...
Abstract Background Adequate level of carbohydrates in aquafeeds help to conserve protein and reduce cost. However, studies have indicated that high-carbohydrate (HC) diet disrupt the homeostasis gut–liver axis largemouth bass, resulting decreased intestinal acetate butyrate level. Method Herein, we had concepted a set feeding experiment assess effects dietary sodium (SA) (SB) on liver health microbiota bass fed an HC diet. The experimental design comprised 5 isonitrogenous isolipidic diets,...
Environmental factors greatly impact infectious disease-related mortality, yet there's a lack of comprehensive global studies on the contemporary burden and trends. This study aims to evaluate trends disease mortality caused by air pollution, unsafe water, poor sanitation, non-optimal temperature across Socio-Demographic Index (SDI) regions from 1990 2019.
PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, were shown to be highly successful. Because primarily functions sensing repairing DNA strand breaks, therapeutic effect inhibition is generally believed attributed impaired repair. We here report that oxidative stress also increased by mediates antitumor effect. showed PARP1 expressed specimens high grade serous carcinoma its activity required unperturbed...
To explore the long-term effect of exposure to ambient air pollution on risk active tuberculosis (TB).We constructed a distributed-lag nonlinear model (DLNM) evaluate relatively influence outdoor PM2.5, PM10, SO2 and NO2 TB in city Lianyungang Jiangsu Province, China.There were 7,282 cases reported study area during 2014-2017, with annual median (interquartile range) concentrations at 45.86 (34.57-64.14) μg/m3, 85.43 (62.86-116.14) 22.00 (15.71-30.86) μg/m3 30.00 (23.29-38.57) respectively....
Dysregulation of G6PD involved in the pentose phosphate pathway (PPP) is known to promote tumorigenesis. The PPP plays a pivotal role meeting anabolic demands cancer cells. However, detailed underlying molecular mechanisms targeting G6PD‐regulated breast remain unclear. In this study, we aimed elucidate pathways mediating effects on progression. Clinical sample analysis found that expression patients was higher than normal controls, and with had poor survival. Gene knockdown or inhibition by...
// Lili Pan 1, 2, * , Yang Li Hai-Ying Zhang 2 Yi Zheng Xiao-Li Liu Hu Wang 3 Jing Yuan-Hua Cai Qiao Wan-Ling Chen Ying Guo Yuan-Mao Huang Feng Qian Jin Jiucun and Shao-Yuan 1 Fujian Institute of Hematology, Provincial Key Laboratory on Department Medical University Union Hospital, Fuzhou, PR China Clinical Colleges, University, State Genetic Engineering Ministry Education Contemporary Anthropology, School Life Sciences, Fudan Shanghai, These authors have contributed equally to this work...