A5100325757- Drug Transport and Resistance Mechanisms
- Phytochemistry and Biological Activities
- Plant-derived Lignans Synthesis and Bioactivity
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Peroxisome Proliferator-Activated Receptors
- Drug-Induced Hepatotoxicity and Protection
- Luminescence and Fluorescent Materials
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Genomics, phytochemicals, and oxidative stress
- Biological and pharmacological studies of plants
- Synthesis and Properties of Aromatic Compounds
- Analytical Chemistry and Chromatography
- Medicinal Plant Pharmacodynamics Research
- Alkaloids: synthesis and pharmacology
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Bioactive Natural Diterpenoids Research
- Diet and metabolism studies
- Essential Oils and Antimicrobial Activity
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
Chinese Academy of Sciences
2015-2025
Zunyi Medical University
2012-2025
Anhui Polytechnic University
2025
Anhui Medical University
2025
Computer Network Information Center
2025
Qiqihar Medical University
2022-2024
Tianjin University of Traditional Chinese Medicine
2024
Southern Medical University
2014-2024
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, murine model of high-fat diet-induced (HFD-induced) was used, and effects alterations in on were determined. Mice treated with antibiotics or tempol exhibited altered bile acid composition, notable increase conjugated metabolites inhibited intestinal farnesoid X receptor (FXR) signaling. Compared control mice, animals...
cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, it imperative to identify effective lead compounds that specifically downregulate the pathway. We report here astin C, a cyclopeptide isolated from medicinal plant Aster tataricus, inhibits inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with C are more susceptible HSV-1 infection. Consistently, markedly attenuates in Trex1-/- BMDM...
Abstract Parabacteroides distasonis ( P. ) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that is decreased patients with hepatic fibrosis, administration of to male mice improves thioacetamide (TAA)- methionine choline-deficient (MCD) diet-induced fibrosis. Administration also leads increased bile salt hydrolase (BSH) activity, inhibition intestinal farnesoid X receptor (FXR) signaling taurochenodeoxycholic acid...
Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase (PARP) activation, downstream effector oxidant-induced DNA damage, is an obligatory step functional metabolic changes nerve. PARP-deficient (PARP−/−) mice were protected from both galactose-induced motor sensory nerve conduction slowing energy failure clearly manifest wild-type (PARP+/+) or galactose-fed...
Activation of farnesoid X receptor (FXR) markedly attenuates development atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that FXR agonist, obeticholic acid (OCA), increases fecal cholesterol excretion and macrophage reverse transport (RCT) dependent on activation hepatic FXR. OCA does increase biliary secretion, but inhibits intestinal absorption. 7α-hydroxylase (Cyp7a1) sterol 12α-hydroxylase (Cyp8b1) partly through inducing small...
A series of chiral binaphthyl-based conjugated polymers enantiomers incorporating boron dipyrromethene (BODIPY) chromophore in the main chain backbone were designed and synthesized by Pd-catalyzed Sonogashira cross-coupling reaction. All them can exhibit strong Cotton effects circularly polarized luminescence (CPL) emission signals THF solution. The CD absorption dissymmetry factors (gabs) (glum) be regulated tuning dihedral angles binaphthyl arising from different substitutions BINOL...
Inflammation in central nervous system (CNS) plays a vital role neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), Lewy body dementia (DLB), HIV-related and traumatic brain injury. Icariside II (ICS II), an active flavonoid compound derived from Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess neuroprotective effect on AD model. However, whether ICS directly protective acute neuroinflammation remains still unclear. Therefore, the...
Male fertility impaired by exogenous toxins is a serious worldwide issue threatening the health of new-born and causing infertility. However, metabolic connection between toxic exposures testicular dysfunction remains unclear.In present study, disorder was investigated using triptolide-induced injury in mice. We found that triptolide induced spermine deficiency resulting from disruption polyamine biosynthesis uptake testis, perturbation gut microbiota. Supplementation with reversed through...
Abstract The role of sperm DNA fragmentation index (DFI) in investigating fertility, embryonic development, and pregnancy is academic interest. However, there ongoing controversy regarding the impact DFI on outcomes safety offspring context Assisted Reproductive Technology (ART). In this study, we conducted an analysis clinical data obtained from 6330 patients who underwent vitro fertilization (IVF) or intracytoplasmic injection (ICSI) at reproductive medical center First People's Hospital...
Objectives Suboptimal health status (SHS) is considered to be an intermediate between disease and health, characterised by a decline in vitality, physiological function the capacity for adaptation. Although incidence of SHS high, underlying causes remain unclear. Lifestyle one most important factors affecting status; however, relationship lifestyle has not been elucidated. Design Cross-sectional survey. Setting A questionnaire, based on ‘Health Promoting Profile-II (HPLP-II)’ ‘Sub-Health...
The AP2/ERF transcription factor, one of the largest gene families in plants, plays a crucial role regulation growth and development, metabolism, responses to biotic abiotic stresses. Castor bean (Ricinus communis L., Euphobiaceae) is most important non-edible oilseed crops its seed oil broadly used for industrial applications. available genome provides great chance identify characterize global information on factors castor bean, which might provide insights understanding molecular basis...
The bile salt export pump (BSEP) is an ATP-binding cassette transporter that serves as the primary system for removing salts from liver. In humans, deficiency of BSEP, which encoded by ABCB11 gene, causes severe progressive cholestatic liver disease early infancy. previous studies Abcb11 in mice generated on a mixed genetic background, animals did not recapitulate human disease. We reasoned may cause unique changes hepatic metabolism are predictive injury. To test this possibility, we first...
Suboptimal health status (SHS) is the intermediate state between and disease, refers to medically undiagnosed or functional somatic syndromes, has been a major global public challenge. However, both etiology mechanisms associated with SHS are still unclear. Breakfast eating behavior dietary pattern marker previous studies have presented evidence of associations failure consume breakfast increased diseases. Accordingly, in view significance behaviors respect status, habits healthy lifestyle,...