A5070273499- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Renal Diseases and Glomerulopathies
- Catalytic C–H Functionalization Methods
- Heart Rate Variability and Autonomic Control
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Advanced Nanomaterials in Catalysis
- Cardiac electrophysiology and arrhythmias
- Synthesis and Biological Evaluation
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Conducting polymers and applications
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Polyoxometalates: Synthesis and Applications
- Click Chemistry and Applications
- Cardiac Valve Diseases and Treatments
- EEG and Brain-Computer Interfaces
Peking University
2016-2025
Tianjin University
2024-2025
Gaochun People's Hospital
2022-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2023-2025
Peking University Third Hospital
2021-2025
Aerospace Center Hospital
2021-2025
Second Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2015-2025
China Academy of Printing Technology
2024-2025
Institute of Chemistry
2024-2025
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction BMPR2 signaling. The best response was achieved with FK506 (tacrolimus), via dual mechanism action as calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), repressor BMP released FKBP12 from...
Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in elucidating structure-function relationships, there still much be learned about mechanisms that link altered cardiac energetics phenotypes. In this work, we test hypothesis changes represent common...
Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes macrophages, we investigated significance pathogenesis AAD its clinical relevance.
Peroxisome proliferator-activated receptor (PPAR)-γ is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion PPARγ smooth muscle cells (SMCs) transgenic mice results PAH. However, the sequelae loss endothelial (ECs) are unknown. Therefore, bred Tie2-Cre flox/flox to induce EC (Tie2 −/− ), assessed PAH by right ventricular systolic pressure (RVSP), RV hypertrophy (RVH), muscularized distal PAs room air (RA), after chronic hypoxia (CH), 4 wk...
We have developed an environmentally friendly and highly efficient method for copper-catalyzed cycloaddition of organic azides terminal alkynes under solvent-free conditions. The protocol uses the cheap easy-to-prepare Cu(PPh3)2NO3 complex as catalyst.
This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis mechanisms these reactions<italic>via</italic>C–N/C–C bond formation.
In this review, we have focused on the recent advances in photocatalytic C–S/P–S bond formation <italic>via</italic> generation of thioyl/sulfonyl radicals and further functionalization.
Objective— We aimed to assess whether exposure higher levels of ambient air pollution impairs HDL (high-density lipoprotein) function and elucidate the underlying biological mechanisms potentially involved. Approach Results— In Beijing AIRCHD study (Air Pollution Cardiovascular Dysfunction in Healthy Adults), 73 healthy adults (23.3±5.4 years) were followed-up with 4 repeated visits 2014 2016. During each visit, concentrations, metrics, parameters inflammation oxidative stress measured....
Abstract Compared to single metallic Ni or Co phosphides, bimetallic Ni–Co phosphides own ameliorative properties, such as high electrical conductivity, remarkable rate capability, upper specific capacity, and excellent cycle performance. Here, a simple one‐step solvothermal process is proposed for the synthesis of bouquet‐like cobalt‐doped nickel phosphite (Ni 11 (HPO 3 ) 8 (OH) 6 ), effect structure on pseudocapacitive performance investigated via series electrochemical measurements. It...
Significance Heart disease is the leading cause of death worldwide, and hypertrophic cardiomyopathy (HCM) most common inherited form heart disease, affecting over 1 in 200 people. Mutations myosin, motor protein responsible for contraction heart, are a HCM but have diverse effects on biomechanics myosin protein. We demonstrate that complex biomechanical mutations associated with can be effectively studied understood using multiscale experimental computational modeling approach. This work...
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need identify new targetable pathways. Dysregulated glycine metabolism has emerged as causative factor therapeutic target NASH. Here, we report that tripeptide DT-109 (Gly-Gly-Leu) dose-dependently attenuates fibrosis mice. To enhance probability...
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
This study aimed to investigate the clinical efficacy and safety of telitacicept in patients with generalized myasthenia gravis (gMG) who tested positive for acetylcholine receptor antibodies or muscle-specific kinase were receiving standard-of-care therapy.