A5062253569- Congenital heart defects research
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Plant Molecular Biology Research
- Food composition and properties
- Hepatitis B Virus Studies
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Cardiomyopathy and Myosin Studies
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- HER2/EGFR in Cancer Research
- Rice Cultivation and Yield Improvement
- Estrogen and related hormone effects
Xiamen University
2025
Fudan University
2022-2025
Shanghai East Hospital
2018-2024
Beijing Fengtai Hospital
2024
Bengbu Medical College
2023-2024
Shanghai Jiao Tong University
2024
Tongji University
2014-2023
Nanjing University of Chinese Medicine
2023
State Key Laboratory of Medical Neurobiology
2022
Yangzhou University
2017-2022
Understanding the mechanisms that control human cardiomyocyte proliferation might be applicable to regenerative medicine. We screened a whole genome collection of miRNAs, identifying 96 capable increasing (DNA synthesis and cytokinesis) iPSC-derived cardiomyocytes. Chemical screening computational approaches indicated most these miRNAs (67) target different components Hippo pathway their activity depends on nuclear translocation transcriptional effector YAP. 53 67 are present in iPSC...
A large portion of idiopathic and familial dilated cardiomyopathy (DCM) cases have no obvious causal genetic variant. Although altered response to metabolic stress has been implicated, the molecular mechanisms underlying pathogenesis DCM remain elusive. The JMJD family proteins, initially identified as histone deacetylases, shown be involved in many cardiovascular diseases. Despite their increasingly diverse functions, whether members play a role remains unclear. We examined Jmjd4 expression...
Abstract A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular niches for replication. However, role intermediate filaments, which are crucial mechanical strength and resilience cell, in bacterial vacuole preservation remains unclear. Here, we show that Salmonella effector SopB reorganizes vimentin network form cage-like structures surround -containing vacuoles (SCVs). Genetic removal markedly disrupts SCV organization, significantly reduces replication...
Biomaterials are extensively used to restore damaged tissues, in the forms of implants (e.g. tissue engineered scaffolds) or biomedical devices pacemakers). Once contact with physiological environment, nanostructured biomaterials undergo modifications as a result endogenous proteins binding their surface. The formation this macromolecular coating complex, known 'protein corona', onto surface nanoparticles and its effect on cell-particle interactions currently under intense investigation. In...
Impairment of intrinsic plasticity is involved in a range neurological disorders such as epilepsy. However, how excitability regulated still not fully understood. Here we report that the epigenetic factor Chromodomain Y-like (CDYL) protein critical regulator initiation and maintenance neuroplasticity by regulating voltage-gated ion channels mouse brains. CDYL binds to regulatory element intron region SCN8A mainly recruits H3K27me3 activity for transcriptional repression gene. Knockdown...
The source-sink relationship determines the overall agronomic performance of rice. Cloning and characterizing key genes involved in regulation source sink dynamics is imperative for improving rice yield. However, few with potential application have been identified. Glucan, Water-Dikinase 1 (GWD1) an essential enzyme that plays a pivotal role first step transitory starch degradation tissues. In present study, we successfully generated gwd1 weak mutants by promoter editing using CRISPR/Cas9...
Abstract Aims Post-natal maturation of mammalian cardiomyocytes proceeds rapidly after birth, with most the myocytes exiting cell cycle, becoming binucleated, and adopting oxidative phosphorylation as primary metabolic route. The triggers transcriptional programmes regulating cardiomyocyte have not been fully understood yet. We performed single-cell RNA-Seq in post-natal rat hearts order to identify important factors for this process. Methods results Single-cell profiling was Day 1 7 hearts,...
A critical but molecularly uncharacterized step in heart formation and regeneration is the process that commits progenitor cells to differentiate into cardiomyocytes. Here, we show endoderm-derived dual Nodal/bone morphogenetic protein (BMP) antagonist Cerberus-1 (Cer1) embryonic stem cell cultures orchestrates two signaling pathways direct SWI/SNF chromatin remodeling complex cardiomyogenic loci multipotent (KDR/Flk1 + ) progenitors, activating lineage-specific transcription. Transient...
Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) has potential to improve efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid easy-to-score screening approach identifying small molecules that affect DSB repair pathways. Using this tool, identified molecule, farrerol, promotes HR but does not NHEJ. Further mechanistic studies indicate...
Optimized source-sink interactions are determinants of both rice yield and quality. However, most source genes have not been well studied in rice, a major grain crop. In this study, OsBMY4 OsISA3, the key β-amylase debranching enzymes that control transient starch degradation leaves, were co-overexpressed order to accelerate efficiency increase sugar supply for sink organs. Systematic analyses transgenic indicated co-overexpression OsISA3 only promoted quality, but also improved seed...
The EphB4 receptor tyrosine kinase together with its preferred ligand, ephrin-B2, regulates a variety of physiological and pathological processes, including tumor progression, forms angiogenesis, cardiomyocyte differentiation bone remodeling. We previously reported the identification TNYL-RAW, 15 amino acid-long peptide that binds to ephrin-binding pocked low nanomolar affinity inhibits ephrin-B2 binding. Although interacts promiscuously all EphB receptors, TNYL-RAW is remarkably selective...
Intermedin (IMD), a member of calcitonin family, was suggested to play role in angiogenesis and cancer. The aim this study investigate the IMD angiogenic process underlying mechanism, possibility for it be used as target angiogenesis-based anticancer therapies.Using vivo vitro 3-dimensional models, we found that induced well-ordered vasculature with hierarchical structure had synergistic effect vascular endothelial growth factor. Using RNA interference, real-time polymerase chain reaction,...