A5101909086- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Extracellular vesicles in disease
- Immune cells in cancer
- Nanocluster Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- interferon and immune responses
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- CRISPR and Genetic Engineering
- Blood Coagulation and Thrombosis Mechanisms
- Calcium signaling and nucleotide metabolism
- Advancements in Transdermal Drug Delivery
- Mesenchymal stem cell research
- Cancer-related gene regulation
Nanchang University
2014-2024
State Key Laboratory of Biotherapy
2012
Sichuan University
2011-2012
West China Second University Hospital of Sichuan University
2012
Cornell University
2002-2006
Vanderbilt University
1996-2002
The calcium release channels (CRC)/ryanodine receptors of skeletal (Sk) and cardiac (C) muscle sarcoplasmic reticulum (SR) are hetero-oligomeric complexes with the structural formulas (ryanodine recepter (RyR)1 protomer)4(FKBP12)4 (RyR2 protomer)4(FKBP12.6)4, respectively, where FKBP12 FKBP12.6 isoforms 12-kDa receptor for immunosuppressant drug FK506. sequence similarity between RyR protomers is 63 85%, respectively. Using 35S-labeled as probes to study interaction CRC, we find that: 1)...
Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial migration in metastatic MDA-MB‑231 cells, but not non-metastatic MCF-7 cells. Inhibition of Drp1-dependent by Mdivi-1 or silencing attenuated hypoxia-induced On the other hand, cisplatin induced significant apoptosis also efficiently prevented cisplatin-induced MMP decrease, ROS production Our data suggest that only regulates breast cancer facilitates...
Isolated skeletal muscle ryanodine receptors (RyRs) complexed with the modulatory ligands, calmodulin (CaM) or 12-kDa FK506-binding protein (FKBP12), have been characterized by electron cryomicroscopy and three-dimensional reconstruction. RyRs are composed of 4 large subunits (molecular mass 565 kDa) that assemble to form a 4-fold symmetric complex that, architecturally, comprises two major substructures, (≈80% total mass) cytoplasmic assembly smaller transmembrane assembly. Both CaM FKBP12...
Abstract Currently, most thrombolytic agents are limited by short circulation time and excessive dose needed for clinical therapy, which increases lethal risk intracranial hemorrhage. Here, a near‐infrared‐triggered, controlled‐release system, using gold@mesoporous silica core–shell nanospheres (Au@MSNs) with phase‐changed material 1‐tetradecanol, is formulated to release urokinase plasminogen activators (uPA) on demand. The prepared system presents sensitive releasing uPA, owing an elevated...
Bone morphogenetic protein 10 (BMP10) belongs to the TGFβ-superfamily. Previously, we had demonstrated that BMP10 is a key regulator for ventricular chamber formation, growth, and maturation. Ablation of leads hypoplastic wall elevated levels are associated with abnormal trabeculation/compaction However, molecular mechanism(s) by which regulates ventricle growth maturation still largely unknown. In this study, sought identify specific transcriptional network potentially mediated BMP10. We...
Asiatic acid promotes Sirt1 expression and inhibits NF-κB-induced microglia activation.
Abstract Endothelial activation by proinflammatory cytokines is closely associated to the pathogenesis of atherosclerosis and other vascular diseases; however, molecular mechanisms controlling endothelial are not fully understood. Here we identify TRIM14 as a new positive regulator via activating NF-κB signal pathway. highly expressed in human cells (ECs) markedly induced inflammatory stimuli such TNF-α, IL-1β, LPS. Overexpression significantly increased expression adhesion molecules VCAM-1,...
Abstract Although the adhesion molecules-mediated leukocyte adherence and infiltration into tissues is an important step of inflammation, post-translational regulation these proteins on endothelial cells poorly understood. Here, we report that TRIM65, ubiquitin E3 ligase tripartite protein family, selectively targets vascular cell molecule 1 (VCAM-1) promotes its ubiquitination degradation, by which it critically controls duration magnitude sepsis-induced pulmonary inflammation. TRIM65...
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death in world. Human amniotic mesenchymal stem cells (hAMSCs) have been characterized with a pluripotency, low immunogenicity and no tumorigenicity. Especially, immunosuppressive anti‐inflammatory effects hAMSCs make them suitable for treating HCC. Here, we reported that administrated by intravenous injection significantly inhibited HCC through suppressing cell proliferation inducing apoptosis...
Abstract Various therapeutic platforms have been developed for repairing bone defects. However, scaffolds possess both cortical bone-matching mechanical properties and excellent osteoconductivity load-bearing defects repair is still challenging in the clinic. In this study, inspired by structure of ferroconcrete, a high-strength bifunctional scaffold has combining surface-modified magnesium alloy as internal skeleton bioglass-magnesium phosphate cement osteoconductive matrix. The combines...
FK506-binding protein (FKBP12) has been found to be associated with the skeletal muscle ryanodine receptor (RyR1) (calcium release channel), whereas FKBP12.6, a novel isoform of FKBP, is selectively cardiac (RyR2). For both RyRs, stoichiometry 4 FKBP/RyR. Although FKBP12.6 differs from FKBP12 by only 18 108 amino acids, binds RyR2 and exchanges bound RyR2, FKBP isoforms bind RyR1 exchange RyR1. To assess acid residues that are critical for selective binding differ were mutated respective...
Intermedin (IMD), a member of calcitonin family, was suggested to play role in angiogenesis and cancer. The aim this study investigate the IMD angiogenic process underlying mechanism, possibility for it be used as target angiogenesis-based anticancer therapies.Using vivo vitro 3-dimensional models, we found that induced well-ordered vasculature with hierarchical structure had synergistic effect vascular endothelial growth factor. Using RNA interference, real-time polymerase chain reaction,...
Systemic thrombolytic drug administration has always gained an unideal therapeutic effect due to the rapid neutralization by its antidotes. It is significant seek approach for targeted delivery thrombus. Here a biocompatible, thrombus-targeted, and low-cost platelet-mimic nanovector was fabricated accomplish sustained urokinase plasminogen activator (uPA) release at thrombus site. The prepared system presented model behavior 30 h burst under near-infrared laser irradiation with hyperthermia...
Significance The formation of ridge-like trabeculae from the myocardium is central to heart formation, as it allows for increase in muscle mass before coronary circulation. We found that cardiomyocytes display spatiotemporal orientation during trabecular formation. Cardiomyocytes Numb and Numblike double knockout abnormal cellular orientation. hearts reduced membrane localized N-cadherin due attenuated recycling membrane. When chick overexpressed knockouts via a mosaic model, defects...
Hey2 gene mutations in both humans and mice have been associated with multiple cardiac defects. However, the currently reported localization of ventricular compact zone cannot explain wide variety Furthermore, it was that, contrast to other organs, Notch doesn't regulate heart. To determine expression pattern regulation Hey2, we used novel methods including RNAscope a CreERT2 knockin line precisely spatiotemporal level during development. We found that is expressed endocardial cells...
A novel dual chain-responsive thrombolytic drug delivery nanoplatform based on black phosphorus nanosheets was designed for thrombolysis.