A5032451240- Genetic and Kidney Cyst Diseases
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Biochemical Analysis and Sensing Techniques
- Biomedical Research and Pathophysiology
- Protist diversity and phylogeny
- Protein Hydrolysis and Bioactive Peptides
- Regulation of Appetite and Obesity
- Influenza Virus Research Studies
- Polyamine Metabolism and Applications
- Genetic Syndromes and Imprinting
- Invertebrate Immune Response Mechanisms
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- melanin and skin pigmentation
- Vector-Borne Animal Diseases
- Fungal Biology and Applications
- Renal and related cancers
- Indoor Air Quality and Microbial Exposure
- Identification and Quantification in Food
Zhejiang University
2024-2025
Tianjin University of Science and Technology
2015-2024
State Key Laboratory of Food Nutrition and Safety
2023
Tianjin Institute of Pharmaceutical Research (China)
2016
China International Science and Technology Cooperation
2016
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2016
Tianjin University
2010-2013
Auburn University
2007-2011
Texas A&M University
2009-2010
Mitchell Institute
2010
Background Intraflagellar transport (IFT) is the bidirectional movement of IFT particles between cell body and distal tip a flagellum. Organized into complexes A B, are composed at least 18 proteins. The function proteins in flagellar assembly has been extensively investigated. However, much less known about molecular mechanism how regulated. Methodology/Principal Findings We herein report identification novel particle protein, IFT25, Chlamydomonas. Dephosphorylation assay revealed that...
As the most common monogenic form of human obesity, about 130 naturally occurring melanocortin-4 receptor (MC4R) gene mutations have been identified. In this study, we reported detailed functional characterization 10 novel MC4R (hMC4R) mutants including R7C, C84R, S127L, S136F, W174C, A219V, P230L, F261S, I317V and L325F. Flow cytometry experiments showed that six mutants, P230L decreased cell surface expression. The other four are expressed at similar levels as wild-type hMC4R. Binding...
In the developing mammalian heart, endocardium and myocardium are separated by so-called cardiac jelly. Communication between is essential for morphogenesis. How membrane-localized receptors ligands achieve interaction across jelly not understood. Working in mouse morphogenesis models, we used a variety of cellular, imaging, genetic approaches to elucidate this question. We found that interacted directly through microstructures termed tunneling nanotube–like structures (TNTLs). TNTLs...
DYF-1 is a highly conserved protein essential for ciliogenesis in several model organisms. In Caenorhabditis elegans, serves as an activator anterograde motor OSM-3 of intraflagellar transport (IFT), the ciliogenesis-required motility that mediates flagellar precursors and removal turnover products. zebrafish Tetrahymena influences cilia tubulin posttranslational modification may have more ubiquitous function than OSM-3. Here we address how biochemically interacts with IFT machinery by using...
Significance Bardet-Biedl syndrome (BBS) is a rare human ciliopathy associated with blindness, obesity, and kidney anomalies. It caused by defects in the assembly or transport of BBSome, conserved octamer BBS proteins, which assists intraflagellar (IFT) removal signaling proteins from cilia. Here, we show that GTPase component IFT-B1, IFT22, autonomous IFT-B1 association, binds stabilizes BBS3 cell body. When both are their GTP-bound state, IFT22 recruit BBSome to basal body for loading onto...
Certain ciliary signaling proteins couple with the BBSome, a conserved complex of Bardet–Biedl syndrome (BBS) proteins, to load onto retrograde intraflagellar transport (IFT) trains for their removal out cilia in Chlamydomonas reinhardtii . Here, we show that loss Arf-like 6 (ARL6) GTPase BBS3 causes protein phospholipase D (PLD) accumulate cilia. Upon targeting basal body, BBSomes enter and cycle through via IFT, while GTP-bound state separates from BBSomes, associates membrane,...
To study the associations between dorm environment and occupants' health, a nested case-control on 348 college students was carried out in 2006-2007 at Tianjin University, China. Two hundred twenty-three rooms where 'cases' 'controls' resided were inspected. Measured variables ventilation rate, air temperature, relative humidity indoors. Allergic symptoms last 12 months self-reported by occupants. Adjusted odds ratios (AORs) of 'localized moldy smell/moisture indicator' 'special places'...
Dissolved organic matter (DOM) serves as a major carbon and nutrient pool in oceans, recalcitrant DOM are the primary sources for sequestration depths. Here, we demonstrate critical roles of algae-associated microorganisms (mainly heterotrophic bacteria) transformation dissolved through laboratory cultures model diatom, Skeletonema dohrnii .
A cross-sectional study was carried out at Tianjin University campus, China, from February 21 to June10, 2006, survey the association between dampness in dorms and allergy airways infection among college students. The health condition were self-reported by 3436 students living 1511 dorm rooms located 13 buildings on campus. selected according their positions, construction periods occupant densities. symptoms involved wheezing, dry cough during night, rhinitis, eczema, cold/flu, ear...