A5100378693- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Ginkgo biloba and Cashew Applications
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Gout, Hyperuricemia, Uric Acid
- Flavonoids in Medical Research
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Phytochemistry and Biological Activities
- Musculoskeletal pain and rehabilitation
- Phytochemicals and Antioxidant Activities
- Berberine and alkaloids research
- Microbial Natural Products and Biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Medicinal Plants and Bioactive Compounds
- Entrepreneurship Studies and Influences
- Silymarin and Mushroom Poisoning
- Inflammatory mediators and NSAID effects
- Phase Equilibria and Thermodynamics
- Algal biology and biofuel production
- Shoulder Injury and Treatment
- Medicinal plant effects and applications
Changchun Normal University
2009-2025
First Affiliated Hospital of Henan University
2024
University of Chinese Academy of Sciences
2014-2023
Chinese Academy of Sciences
2014-2023
Guangzhou Medical University
2023
Dalian Polytechnic University
2021-2023
Beijing University of Chinese Medicine
2016-2023
Chengdu Institute of Biology
2023
Yantai Institute of Coastal Zone Research
2023
China National Environmental Monitoring Center
2023
Abstract Qishen granules (QSG), a traditional Chinese medicine, have been prescribed widely in the treatment of coronary heart diseases. Previous studies demonstrated that QSG had anti-inflammatory and cardio-protective effects mice with acute myocardial infarction (AMI). However, mechanisms by which attenuate inflammation prevent post-AMI failure (HF) are still unclear. In this study, we explored vitro vivo experiments. A novel inflammatory injury model H9C2 cells was induced...
Objectives: Ischemic stroke is a severe neurological disorder with high morbidity, mortality, and disability rates, posing substantial burden on patients, families, healthcare systems. Soy isoflavone (SI), naturally occurring phytoestrogen, has demonstrated promising neuroprotective effects. This study aimed to evaluate the anti-stroke efficacy of SI elucidate its underlying mechanisms through integrated phytochemical profiling, network pharmacology, both in vitro vivo experimental...
Summary Supercritical CO 2 fluid extraction technology was used to extract oil from rapeseed. Extraction temperature, pressure, time and the sample particle size were selected optimised by response surface methodology. Conventional solvent applied as a comparative method. The maximum yield of 32.65 ± 1.01% achieved at temperature 40 °C pressure 345 bar, using an 3 h 60‐mesh size. chemical compositions rapeseed esterification method investigated GC–MS. result indicates that main fatty acids...
Natural products have become one of the most important resources for discovering novel xanthine oxidase inhibitors, which are commonly employed in treatment hyperuricemia and gout. However, to date, few reports exist regarding use monoterpene glycosides as inhibitors. Thus, we herein report ultrafiltration coupled with liquid chromatography screening glycoside inhibitors from extract Paeonia lactiflora (P. lactiflora), both high-performance counter-current medium-pressure were separate main...
Diabetes mellitus (DM) has become a worldwide health problem. α-Glucosidase inhibitors are widely used in the treatment of type 2 diabetes, and natural products considered as promising sources α-glucosidase inhibitors. In this research, ultrafiltration liquid chromatography with photodiode array detection coupled to electrospray ionization tandem mass spectrometry (Ultrafiltration LC-PDA-ESI/MS) were applied screen identify from Scutellaria baicalensis. Following this, reverse-phase...
Fungal infections caused by opportunistic pathogens, such as Candida albicans, are generally underappreciated the public in spite of their high mortality rates. Antifungal arsenals extremely limited. Herein, based on biosynthetic pathway comparison and functional characterization, CaERG6, a crucial sterol 24-C-methyltransferase involved biosynthesis ubiquitous ergosterol C. was set up an antifungal target. CaERG6 inhibitors were identified from in-house small-molecule library biosensor-based...
Abstract Superoxide anion radical scavenger and xanthine oxidase inhibitor play an important role in the treatment of several relevant human diseases. In present study, ultrafiltration liquid chromatography–mass spectrometry coupled to microplate reader was applied screen identify superoxide scavengers inhibitors from total flavonoids Ginkgo biloba leaves. As a result, four compounds (quercetin, apigenin, kaempferol isorhamnetin) were screened as by LC–MS, 50% scavenging concentration values...
In the present study, anti-inflammation effect of Phellinus igniarius extract was detected on an in vitro model RAW 264.7 cells stimulated using sodium urate. this cell model, content changes inflammatory cytokines, intercellular adhesion molecule-1, and interleukin-1 beta, culture supernatants were enzyme-linked immunosorbent assay. The xanthine oxidase inhibitory activity P. extracts determined a microplate reader. Furthermore, order to identify active compounds igniarius, ultrafiltration...
The Bile-processed Rhizoma coptidis (BRC), which has a colder drug property than (RC), is widely used for the treatment of heat syndrome. We compared pharmacokinetics protoberberine-type alkaloids in BRC and RC rats with syndrome to elucidate bile-processing mechanism.We established rapid sensitive method simultaneously determining three alkaloids: berberine, palmatine, jatrorrhizine, rat plasma based on ultra-performance liquid chromatography/tandem mass spectrometry. separation was carried...
Background: The etiology of Parkinson's disease (PD), a chronic and progressive neurodegenerative disease, is multifactorial but not fully unknown. Until now, no drug has been proven to have neuroprotective or neuroregenerative effects in patients with PD.Objectives: To observe the therapeutic potential Bilobalide (BB), constituent ginkgo biloba, MPTP-induced PD model, explore its possible mechanisms action.Material Methods: Mice were randomly divided into three groups: healthy group, MPTP...
Polygonati Rhizoma (Huangjing) is traditional medicine in China, which can only be used as after being processed. However, there a limited theoretical basis for analyzing the changes chemical components processing. In this study, analytical techniques including Fourier transform infrared spectroscopy, high-performance gel permeation chromatography-evaporative light scattering detection, and HPLC-diode array detection were proposed to perform multiple fingerprint analyses of processed...