A5040046880- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Glass properties and applications
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Force Microscopy Techniques and Applications
- Glycosylation and Glycoproteins Research
- Luminescence Properties of Advanced Materials
- Galectins and Cancer Biology
- Allergic Rhinitis and Sensitization
- Corneal Surgery and Treatments
- Mechanical and Optical Resonators
- Protease and Inhibitor Mechanisms
- Quantum Dots Synthesis And Properties
- Advanced Wireless Communication Techniques
- Advanced MIMO Systems Optimization
- Synthesis and biological activity
- Advanced MEMS and NEMS Technologies
- HER2/EGFR in Cancer Research
- Microwave Dielectric Ceramics Synthesis
- Wireless Communication Networks Research
- Cardiovascular Effects of Exercise
- Retinal and Macular Surgery
- PI3K/AKT/mTOR signaling in cancer
Jiangsu Food and Pharmaceutical Science College
2025
Tsinghua University
2013-2024
State Key Laboratory of Membrane Biology
2024
Huazhong University of Science and Technology
2019-2024
BOE Technology Group (China)
2024
Virginia Tech
2022-2024
Shanghai University
2019-2024
Tsinghua Sichuan Energy Internet Research Institute
2022-2024
Taizhou Second People's Hospital
2022-2023
BioAtla (United States)
2020-2023
B lymphocytes use cell receptors (BCRs) to sense the physical features of antigens. However, sensitivity and threshold for activation BCRs resulting from stimulation by mechanical forces are unknown. Here, we addressed this question using a double-stranded DNA-based tension gauge tether system serving as predefined force ranging 12 56 pN. We observed that IgM-BCR is dependent on exhibits multi-threshold effect. In contrast, isotype-switched IgG- or IgE-BCR only requires low less than pN,...
Doxorubicin is an effective chemotherapeutic agent, but its use limited by acute and chronic cardiotoxicity. Exercise training has been shown to protect against doxorubicin-induced cardiotoxicity, the involvement of immune cells remains unclear. This study aimed investigate role exercise-derived B in protecting cardiotoxicity further determine whether cell activation antibody secretion play a this protection.
The actin cytoskeleton is dynamically remodeled during Fcgamma receptor (FcgammaR)-mediated phagocytosis in a phosphatidylinositol (4,5)-bisphosphate (PIP(2))-dependent manner. We investigated the role of type I 4-phosphate 5-kinase (PIP5K) gamma and alpha isoforms, which synthesize PIP(2), phagocytosis. PIP5K-gamma-/- bone marrow-derived macrophages (BMM) have highly polymerized are defective attachment to IgG-opsonized particles FcgammaR clustering. Delivery exogenous PIP(2) rescued these...
With the increasing public awareness of environmental protection and popularisation suppliers' green production, a growing number e-tailers are also investing in products or services. The greenization an e-tailer brings additional sales to online channel but weakens bargaining power supplier further complicates supplier's format choice. This study focuses on interaction between e-tailer's investment strategy choice format. First, we find that forces consider new factor, efficiency, which...
Abstract Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed activated B cells, it not clear how MCT1-governed monocarboxylates transportation functionally coupled to antibody production during the glucose metabolism. Here, we report that cell-lineage deficiency of significantly influences class-switch recombination (CSR), rendering impaired IgG responses Mct1 f/f Mb1 Cre mice after immunization. Metabolic...
The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed requires BCR signaling molecules. PMA-induced PKCβ can bypass Btk and PLC-γ2 molecules are usually required for cells discriminate substrate stiffness. Instead, PKCβ-dependent FAK is required, leading FAK-mediated potentiation spreading adhesion responses. inactivation or deficiency...
Abstract Gastric cancer (GC) is one of the most common malignancies and its prognosis extremely poor. This study identifies a novel oncogene, microfibrillar-associated protein 2 (MFAP2) in GC. With integrative reanalysis transcriptomic data, we found MFAP2 as GC prognosis-related gene. And aberrant expression was explored samples. Subsequent experiments indicated that silencing exogenous could affect motility cells. The inhibition be rescued by another FAK activator, fibronectin. process...
Niemann-Pick C1-like 1 (NPC1L1) plays a critical role in the enterohepatic absorption of free cholesterol. Cellular cholesterol depletion induces transport NPC1L1 from endocytic recycling compartment to plasma membrane (PM), and replenishment causes internalization together with via clathrin-mediated endocytosis. Although has been characterized, other proteins involved are largely unknown. Most vesicular trafficking events dependent on cytoskeleton motor proteins. Here, we investigated roles...
Receptor for advanced glycation end products (RAGE) may be involved in the pathogenesis of cancer progression. Pathological effects mediated via RAGE are physiologically inhibited by soluble (sRAGE). The aim this study was to identify sRAGE and expression profile lung patients. An ELISA method used quantify serum 45 individuals. Additionally, surgical specimens 28 patients were also included immunohistochemistry. Serum significantly decreased compared with controls (vs. healthy donors,...
Virus infection activates host cellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which regulates diverse activities related to cell growth, survival, and apoptosis. The present study demonstrated for first time that porcine circovirus type 2 (PCV2), a major causative agent of postweaning multisystemic wasting syndrome, is an emerging important swine disease, can transiently induce PI3K/Akt pathway in cultured cells at early step during PCV2...
A physics-based analytical model of electrostatic potential for short-channel junctionless double-gate MOSFETs (JLDGMTs) operated in the subthreshold regime is proposed, which full two-dimensional (2-D) Poisson’s equation solved channel region by a method series expansion similar to Green’s function. The expression proposed completely rigorous and explicit. Based on this expression, models threshold voltage, swing, drain current JLDGMTs were derived. Subthreshold behavior was studied detail...
T regulatory (Treg) cells are essential for self-tolerance whereas they detrimental dampening the host anti-tumor immunity. How Treg adapt to environmental signals orchestrate their homeostasis and functions remains poorly understood. Here, we identified that transcription factor EB (TFEB) is induced by nutrition deprivation or interleukin (IL)-2 in CD4 + cells. The loss of TFEB leads reduced accumulation impaired function mouse models cancer autoimmune disease. intrinsically regulates genes...
We report the chemical synthesis of first photo-activatable protein antigen that can be used to study antigen–antibody interaction mediated responses in B cells.
B lymphocytes use cell receptors (BCRs) to sense the chemical and physical features of antigens. The activation isotype-switched IgG-BCR by mechanical force exhibits a distinct sensitivity threshold in comparison with IgM-BCR. However, molecular mechanisms governing these differences remain be identified. In this study, we report that low is highly dependent on tethering cytoplasmic tail heavy chain (IgG-tail) plasma membrane. Mechanistically, show positively charged residues IgG-tail play...