A5100709904- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Immune Cell Function and Interaction
- interferon and immune responses
- Aquaculture disease management and microbiota
- Kruppel-like factors research
- Artificial Intelligence in Healthcare
- Cancer-related molecular mechanisms research
- Force Microscopy Techniques and Applications
- Ubiquitin and proteasome pathways
- Viral Infections and Outbreaks Research
- Machine Learning in Healthcare
- High Altitude and Hypoxia
- RNA regulation and disease
- Gut microbiota and health
- Influenza Virus Research Studies
- Respiratory viral infections research
- Occupational Health and Performance
- RNA and protein synthesis mechanisms
- Liver physiology and pathology
- Advanced Fluorescence Microscopy Techniques
- FOXO transcription factor regulation
Liaoning University
2018-2025
Nanfang Hospital
2016-2021
Southern Medical University
2016-2021
Tsinghua University
2015-2019
Center for Life Sciences
2019
Key Laboratory of Guangdong Province
2016
B cells use B‐cell receptors (BCRs) to sense antigens that are usually presented on substrates with different stiffness. However, it is not known how substrate stiffness affects proliferation, class switch, and in vivo antibody responses. We addressed these questions using polydimethylsiloxane (PDMS) (20 or 1100 kPa). Live cell imaging experiments suggested stiffer more efficiently trigger the synaptic accumulation of BCR phospho‐Syk molecules compared softer substrates. In vitro expansion...
CD8+ T cell immune responses are critical for combating infectious diseases and tumours1–3. Antigen cross-presentation, primarily occurring at the endoplasmic reticulum (ER) of dendritic cells, is essential protein-based vaccines to induce responses4. Current efforts have focused on antigen delivery tissue cellular levels, whereas subcellular has been limited facilitating escape from lysosomes into cytosol. In absence a small-sized high-affinity ER-targeting molecule, importance 'last mile'...
B lymphocytes use cell receptors (BCRs) to recognize membrane-bound antigens further initiate spreading and contraction responses during activation. We combined traction force microscopy live-cell imaging profile the origin, dynamics, function of generation in these responses. showed that activation required 10 20 nN when encountering presented by substrates with stiffness values from 0.5 1 kPa, which mimic rigidity antigen-presenting cells vivo. Perturbation experiments revealed F-actin...
The mechanosensing ability of lymphocytes regulates their activation in response to antigen stimulation, but the underlying mechanism remains unexplored. Here, we report that B cell mechanosensing-governed requires BCR signaling molecules. PMA-induced PKCβ can bypass Btk and PLC-γ2 molecules are usually required for cells discriminate substrate stiffness. Instead, PKCβ-dependent FAK is required, leading FAK-mediated potentiation spreading adhesion responses. inactivation or deficiency...
The effects of dietary emodin supplementation on the growth, gut health, and microbiota common carp (Cyprinus carpio) were evaluated in this study. basal diet (CONTROL group) was supplemented with 5 g/kg (EMODIN group), 10 20 for 6 weeks. Compared CONTROL alone group, EMODIN groups had a significantly increased weight gain rate (WG%), specific growth (SGR%), condition factor ratio (CF%) decreased feed conversion (FCR). activities intestinal digestive enzymes, including α-amylase (AMS),...
Early diabetes screening can effectively reduce the burden of disease. However, natural population-based projects require a large number resources. With emergence and development machine learning, researchers have started to pursue more flexible efficient methods screen or predict type 2 diabetes.The aim this study was build prediction models based on ensemble learning method for further improve health status population in noninvasive inexpensive manner.The dataset building evaluating model...
Abstract Background Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds cancers. Recently, TLE3 together with many other genes involved Wnt/β-catenin pathway were detected hyper-methylated colorectal cancer (CRC). However, the potential role underlying mechanism CRC progression remain scarce. Methods Gene expression profiles analyzed The Cancer Genome Atlas (TCGA) microarray dataset 41...
To investigate the effects and underlying molecular mechanisms of interaction between non-structural protein 1 (NS1) nucleolar coiled-body phosphoprotein (NOLC1) on rRNA synthesis through telomeric repeat-binding factor 2 (TRF2) under stress in avian influenza A virus infection. The analysis TRF2 ties into exploration ribosomal L11 (RPL11) mouse double minute (MDM2) because has been found to interact with NOLC1, RPL11-MDM2 pathway plays an important role regulation cellular processes. Both...
Objective To analyze pulmonary functions in military pilots and provide reference for the corresponding aeromedical care. Methods One hundred ninety who took annual physical examination were grouped by flight time, type of aircraft, smoking index body mass index. Their functions, including lung volume, ventilation function small airway function, analyzed. The results expressed percentages actual to predictable value. Results There 70 cases (36.84%) showed abnormalities 190...
Maintaining proper blood flow is critical to promoting good health. Nattokinase a serine protease from Bacillus subtilis that has significant in vitro thrombolytic activity, but its mechanism as dietary supplement prevent thrombosis through intestinal absorption and transport still unclear.