A5086324712- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Ocular Diseases and Behçet’s Syndrome
- Cancer Immunotherapy and Biomarkers
- Herbal Medicine Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Telomeres, Telomerase, and Senescence
- Muscle Physiology and Disorders
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Ion Channels and Receptors
- Cholesterol and Lipid Metabolism
- Cytomegalovirus and herpesvirus research
- Bioactive Compounds and Antitumor Agents
- Colorectal Cancer Treatments and Studies
- Calcium signaling and nucleotide metabolism
- Inflammatory Bowel Disease
- Gout, Hyperuricemia, Uric Acid
Center for Life Sciences
2022-2025
Tsinghua University
2020-2025
State Key Laboratory of Membrane Biology
2023-2024
Abstract Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed activated B cells, it not clear how MCT1-governed monocarboxylates transportation functionally coupled to antibody production during the glucose metabolism. Here, we report that cell-lineage deficiency of significantly influences class-switch recombination (CSR), rendering impaired IgG responses Mct1 f/f Mb1 Cre mice after immunization. Metabolic...
The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in cells and plays a crucial role the formation immunological synapse activation. Physiologically, expression level positively correlated influenza-specific antibody production low newborns seniors. Pathologically, positive correlation established between clinical manifestations systemic lupus erythematosus (SLE)...
Inflammatory bowel diseases (IBDs) contribute to the tumorigenesis of colorectal cancer (CRC). Here, we describe a step-by-step protocol for construction colitis-associated CRC murine model by sequential utilization azoxymethane and dextran sulfate sodium. We also detail steps determine degree intestinal inflammation generate colorectum Swiss roll further histopathological analyses. This is convenient reproducible induction general chemical reagents. For complete details on use execution...
TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of in Behçet's disease (BD), inflammatory disorder. Using serum metabolomics peripheral immunocyte transcriptomics, find that polymorphonuclear neutrophil (PMN) from patients with BD (BD-PMN) has dysregulated mevalonate pathway subsequently increased farnesyl pyrophosphate (FPP) levels. Mechanistically, FPP induces TRPM2-calcium signaling...
Abstract All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs). In addition well‐characterized DAMPs such as high‐mobility group box 1 and adenosine triphosphate, studies on new classes emerged. Here, we review recent reports a class isoprenoid‐derived DAMPs, including farnesyl pyrophosphate geranylgeranyl...
Background: Behçet's disease (BD) is a systemic vasculitis characterized by hyperactivation of polymorphonuclear neutrophil (PMN) that overproduce proinflammatory cytokines and extracellular traps (NETs).Methods: Focusing on immunometabolism, we comprehensively analyzed serum metabolomics peripheral immune cell transcriptomics in BD patients sex- age-matched healthy controls (HC). We further intervened critical enzymes mevalonate pathway to elucidate metabolite farnesyl pyrophosphate (FPP)...