A5090816390- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Autoimmune and Inflammatory Disorders Research
- Cellular Mechanics and Interactions
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tracheal and airway disorders
- Immune responses and vaccinations
- Chronic Lymphocytic Leukemia Research
- IL-33, ST2, and ILC Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent and Pediatric Healthcare
- interferon and immune responses
- Cystic Fibrosis Research Advances
- Neurogenetic and Muscular Disorders Research
Chongqing Medical University
2016-2025
Children's Hospital of Chongqing Medical University
2016-2025
Lanzhou University
2005-2025
First Hospital of Lanzhou University
2012-2025
China International Science and Technology Cooperation
2015-2024
National Heart Centre Singapore
2024
Chinese PLA General Hospital
2021-2024
San Raffaele University of Rome
2024
Vita-Salute San Raffaele University
2024
University of Jinan
2022-2023
Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation B-cell antigen (BCR) critical suppressing self-reactive B cells; however, mechanism underlying negative remains elusive. Using genetically manipulated mouse models total internal reflection fluorescence microscopy, we demonstrate that neuronal Wiskott–Aldrich syndrome protein (N-WASP), which coexpressed with WASP in all immune cells, a regulator...
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and leading infant hospitalization worldwide. Uncontrolled response to RSV mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activity an inhibitor TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits TRIF-dependent pathway through upregulation SARM post-RSV infection. BALB/c mice were infected with injected 1 h...
Abstract Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 ( CXCR4 ) gene. We characterize unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct genetic variants within our cohort, 11 were novel pathogenic affecting 15 individuals (23%). All affect same region impair...
ABSTRACT Respiratory syncytial virus (RSV) is the most commonly identified viral agent in young children with acute respiratory tract infections (ARIs) and often causes repeated throughout life. This study investigated genetic variability of attachment (G) protein gene among RSV strains prevalent southwestern China. Reverse transcription-PCR (RT-PCR) for a fragment G was performed nasopharyngeal aspirates (NPAs) collected from ARIs hospitalized Chongqing Children's Hospital, Chongqing, A...
Background Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study assess the impact HBoV viral load on clinical characteristics children who were positive suffered severe LRTI. Methods Lower aspirates from 186 hospitalized with LRTI obtained by bronchoscopy. HBoVs detected real-time PCR other 10 infectious agents examined using and/or...
Background Infections are the major cause of morbidity and mortality in patients with primary immunodeficiency disease (PID). Timely accurate microbiological diagnosis is particularly important these patients. Metagenomic next-generation sequencing (mNGS) has been used for pathogen detection recently. However, few reports describe use mNGS identification PID. Objective To evaluate utility detecting pathogens PID, to compare it conventional tests (CMT). Methods This single center...
Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department China. Anticoagulant needed to prevent clotting extracorporeal circulation during CRRT. Regional citrate anticoagulation (RCA) has been shown potentially be safer and more effective now recommended as preferred anticoagulant method However, there still a lack of unified standards RCA management world, are many problems using this clinical practice. The Emergency Medical...
The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in cells and plays a crucial role the formation immunological synapse activation. Physiologically, expression level positively correlated influenza-specific antibody production low newborns seniors. Pathologically, positive correlation established between clinical manifestations systemic lupus erythematosus (SLE)...
Abstract Intestinal glucagon-like peptide-1 (GLP-1) is a hormone that stimulates insulin secretion and acts as neuropeptide to control glucose homeostasis, but little known whether intestinal GLP-1 has any effect in the of hepatic production (HGP). Here we found intraduodenal infusion activated duodenal PKC- δ , lowered HGP was accompanied by decrease expression gluconeogenic enzymes an increase signaling rats. However, gut co-infusion either receptor antagonist Ex-9, or inhibitor rottlerin...
Talaromyces (Penicillium) marneffei is an AIDS-defining infection in Southeast Asia and associated with high mortality. It rare non-immunosuppressed individuals, especially children. Little known about host immune response genetic susceptibility to this endemic fungus. Genetic defects the interferon-gamma / STAT1 signaling pathway, CD40 ligand- IL12 IL12-receptor-mediated crosstalk between phagocytes T-cells, STAT3-mediated Th17 differentiation have been reported HIV-negative children...
Abstract Background Necrotizing enterocolitis (NEC) remains a life-threatening disease in neonates . Numerous studies have shown correlation between the intestinal microbiota and NEC, but causal link unclear. This study aimed to demonstrate role of gut NEC explore potential mechanisms involved. Methods Eighty-one fecal samples from patients with eighty-one matched controls (matched infants by gestational age, birth weight, date birth, mode delivery feeding patterns) were collected. To if...
Translation regulatory long non-coding RNA 1 (TRERNA1) plays critical roles in cancer biology. We predicted the direct interaction of TRERNA1 with microRNA (miR)-23a, which promotes granulosa apoptosis. Granulosa apoptosis is involved premature ovarian failure (POF). This study was therefore carried out to explore involvement and miR-23a POF. The expression POF control groups were detected by RT-qPCRs. subcellular locations cell line COV434 fractionation assay. between using IntaRNA2.0....
Abstract Macrophage activation syndrome (MAS) is a rare, potentially life-threatening condition in rheumatic diseases. The main treatment includes high-dose corticosteroids and immunosuppressive drugs, although cytokine inhibitors like anakinra or tocilizumab (TCZ) have been reported more recently. We report one case child with systemic juvenile idiopathic arthritis (sJIA). He became progressively hypoxic was transferred to the paediatric intensive care unit (PICU) after TCZ for 4 days. An...
Human metapneumovirus (hMPV) is the main pathogen causing respiratory tract infection in susceptible populations, particularly children and elderly. Specimens were collected from hospitalized with acute lower infections (ALRTI), hMPV was detected by using real-time reverse transcription-PCR (RT-PCR). The full-length G gene of amplified RT-PCR. A total 1,410 nasopharyngeal aspirates (NPAs) April 2008 to March 2011, 114 (10.2%) positive for hMPV. Most hMPV-positive <5 years age. rate peaked...
Kawasaki syndrome (KS) is the leading cause of acquired heart disease in childhood developed countries. This study was designed to identify clinical characteristics a large cohort KS China and explore risk factors for coronary artery lesions. Clinical records 1370 patients with acute were retrospectively reviewed. The features different age groups analyzed, multivariate logistic regression analysis performed lesions caused by KS. prevalence redness at Bacille Calmette-Guèrin inoculation site...
EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, has been detected sporadically. However, the US and Canada have experienced outbreaks of between August December 2014. This study aimed to investigate molecular epidemiology clinical characteristics in Chongqing, Southwestern China. From January 2012 November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children RTIs. Among NPAs, was 19 samples (1.0%, 19/1876). Of...
CD40 ligand (CD40L) deficiency is a rare but life-threatening primary immunodeficiency caused by mutations in the CD40L gene. Here, we investigated cohort of 40 genetically diagnosed CD40L-deficient patients from Chinese mainland, analysed their clinical and genetic data, examined expression, proportion T cell subsets, B subsets follicular helper (Tfh) cells. The aim was to provide complete picture deficiency. Initial presentations patient mainly involved recurrent fever (47.5%)...