A5101520647- Lung Cancer Treatments and Mutations
- Respiratory viral infections research
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
- Congenital Diaphragmatic Hernia Studies
- Ferroptosis and cancer prognosis
- Asthma and respiratory diseases
- Pleural and Pulmonary Diseases
- Polyomavirus and related diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infections and Vectors
- Ultrasound in Clinical Applications
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Pneumonia and Respiratory Infections
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Parvovirus B19 Infection Studies
First Affiliated Hospital of Guangzhou Medical University
2015-2025
First People's Hospital of Jingzhou
2025
Yangtze University
2025
State Key Laboratory of Respiratory Disease
2015-2024
Guangzhou Medical University
2015-2024
Children's Hospital of Chongqing Medical University
2014-2024
Chongqing Medical University
2014-2024
Zhejiang Chinese Medical University
2022-2024
China Medical University
2024
Chongqing Three Gorges University
2024
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and leading infant hospitalization worldwide. Uncontrolled response to RSV mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activity an inhibitor TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits TRIF-dependent pathway through upregulation SARM post-RSV infection. BALB/c mice were infected with injected 1 h...
Checkpoint inhibitor-related pneumonitis (CIP) is a potentially fatal immune-related adverse event that occurs during treatment with immune checkpoint inhibitors (ICIs). However, the roles played by peripheral blood parameters in CIP development remain unclear. Here, we aimed to identify which biomarkers correlated and prognosis of patients lung cancer.We conducted retrospective analysis 87 (CIP group) without (control group). Cytokines, routine, lactate dehydrogenase (LDH) albumin (ALB)...
Although pleural fluid lactate dehydrogenase (LDH) and adenosine deaminase (ADA) levels are often used to distinguish between tuberculous effusion (TPE) parapneumonic (PPE), this can be challenging as the LDH level may vary from normal severely increased in PPE a significantly elevated ADA is frequently measured both conditions. In study, we evaluated use of LDH/ADA ratio new parameter discriminate TPE PPE.A retrospective study was conducted patients with pathologically-confirmed (n = 72)...
Immune checkpoint inhibitors (ICIs), is characterized by durable responses and improved survival in nonsmall cell lung cancer (NSCLC). However, there a lack of predictive biomarkers to optimize the use ICIs cancers. The clinical benefit patients with adenocarcinoma (LUAD) harboring TP53 mutations undergoing conventional treatments need be optimized. Recently, studies indicated that may associated treated ICIs. immunotherapy cohort was used estimate association immune prognosis LUAD. Genomic...
Abstract Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause ST respiratory tract infection (RTI) children. Nasopharyngeal aspirate samples were collected and assessed for common viruses. relationships between virus infections secondary analyzed retrospectively. blood platelet count the presence viruses determined 3156 RTI patients 817 (25.9%) cases ≥500 × 10 9 /L considered as group. Compared normal group, detection rates...
Circulating tumor cells (CTCs) represent a collection of heterogeneous cells. Studies have shown epithelial CTCs and folate receptor (FR) positive could be used as diagnostic biomarkers for lung cancer (LC). This study aimed to determine whether cell surface vimentin (CSV) biomarker LC well.78 treatment-naïve non-small-cell (NSCLC) patients, 21 patients with benign diseases (BLD) 9 healthy donors (HD) were enrolled in this study. CTC detection was performed using CytoSorter® mesenchymal kit...
Background While immune checkpoint inhibitors (ICIs) are a beacon of hope for non-small cell lung cancer (NSCLC) patients, they can also cause adverse events, including inhibitor pneumonitis (CIP). Research shows that the inflammatory microenvironment plays vital role in development CIP. However, (IME) CIP is still unclear. Methods We collected cohort NSCLC patients treated with ICIs included eight individuals (CIP group) and 29 without (Control group). CIBERSORT xCell algorithm were used to...
Respiratory syncytial virus (RSV) is one of the most common causes lower respiratory tract infections (LRTI). However, only limited information available regarding its seasonality and relationship with birth month. A retrospective hospital-based study was carried out from June 2009 to May 2019 in Chongqing, southwest China. LRTI cases under 5 years were enrolled this PCR used detect 8 viruses. RSV determined using "average annual percentage" (AAP) "percent positivity" method. total 6991...
Abstract Background The treatment of extensive stage small‐cell lung cancer (ES‐SCLC) has only made modest progress in the past decade, with two immune checkpoint inhibitors (ICIs), atezolizumab and durvalumab, approved for SCLC by January 2022. However, currently, there is limited real‐world data on ES‐SCLC patients received immunotherapy. Methods We retrospectively collected analyzed demographic at First Affiliated Hospital Guangzhou Medical University from 2017 to Survival prognosis...
The quality of life for patients with advanced cancer declines, tending to deteriorate further as they approach the end their lives. This retrospective study aimed evaluate potential benefits incorporating early palliative care into routine or metastatic bladder cancer. A total 97 from January 2022 May 2024 were included. Amongst them, 46 received treatment and (observation group) 51 only (control group). Assessments using Functional Assessment Cancer Therapy-General (FACT-G), Brief Pain...
Clinical Practice Points•Genetic alterations in v-Raf murine sarcoma viral oncogene homolog B (BRAF), including V600E, are implicated as bypass mechanisms developing resistance to osimertinib; however, treatment strategies that simultaneously target concomitant actionable mutations BRAF and epidermal growth factor receptor (EGFR) remain limited.•A combination of osimertinib vemurafenib was administered third-line therapy two patients with advanced lung adenocarcinoma after V600E identified...
Chronic obstructive pulmonary disease (COPD) is a complex syndrome with poorly understood mechanisms driving its early progression (GOLD stages 1-2). Elucidating the genetic factors that influence early-stage COPD, particularly those related to airway inflammation and remodeling, crucial. This study analyzed lung tissue sequencing data from patients COPD (GSE47460) smoke-exposed mice. We employed Weighted Gene Co-Expression Network Analysis (WGCNA) machine learning identify potentially...
Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets breast tumor cells an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote via PITPNM3. In addition, we found pachymic acid (PA) dose-dependently inhibit migration and invasion MDA-MB-231 cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained PA suppress phosphorylation PITPNM3...
Multidrug resistance (MDR) is a major obstacle to the chemotherapeutic treatment of breast cancer. Germacrone, main component Rhizoma Curcuma, has been shown possess antitumor, anti-inflammatory and immunomodulatory properties. The aim present study was investigate effect germacrone on MCF-7/Adriamycin (ADR) multidrug-resistant human cancer cells. MCF-7/ADR cells with combination ADR resulted in an increase cytotoxicity compared that alone, as determined using MTT assay. Flow cytometric...